FLT3 D839G

CI-VAR-00000583Explore in graph →ClinVar 376014 CIViC 3160

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia1
FLT3 D839G	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID8927 Single strand polymorphism targeting FLT3 in addition to RUNX1, KIT, CEBPA, PTPN11, and NRAS was carried out to identify novel recurring gene mutations in an acute myeloid leukemia cohort comprised of… (full text at CIViC) PMID 15667533 · Smith et al., 2005 · Open in CIViC	civic
Acute Promyelocytic Leukemia1
FLT3 D839G	(prognostic)	Prognostic	C	Supports Poor Outcome	1	submitted	EID8908 This is a case report about an adult patient with acute promyelocytic leukemia (APL) who had relapse in a testicle prior to systemic relapse of APL. Retrospective analysis of the preserved samples fro… (full text at CIViC) PMID 23816818 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Unmapped disease1unmapped disease
FLT3 D839G	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID8656 Functional evaluation of FLT3-D839G was performed by analyzing proliferation, apoptosis, receptor alteration and signaling in vitro. When compared to FLT3-WT expressing cells, FLT3-D839G showed signif… (full text at CIViC) PMID 24608088 · Janke et al., 2014 · Open in CIViC	civic