Publication
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
Authors not recorded
J Clin Oncol2009PMID 19667267stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerRenal Cell Carcinomacivic_curation1.00
- drugSunitinibcivic_curation1.00
- geneFLT3civic_curation1.00
- variantFLT3 T227Mcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19667267
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FLT3 T227M1 | ||||||||
| Sunitinib | Renal Cell CarcinomaCURATED_BROADER | Predictive | B | Supports Adverse Response | 3 | accepted | EID1317In 219 patients with mostly Renal Cell Carcinoma and some Gastrointestinal Stromal tumors given sunitinib treatment, FLT3 T227M (rs1933437) was associated with the development of leukopenia. 95% confi… (full text at CIViC) PMID 19667267 · van Erp et al., 2009 · Open in CIViC | civic |