Variant · Fusion
FLT3 Fusion
CI-VAR-00001529Explore in graph →CIViC 5523
Curated evidence
Evidence by cancer (3 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23873282
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Myeloid/Lymphoid Neoplasm1unmapped disease | ||||||||
| ETV6::FLT3 Fusion | Transplantation | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID13099This study highlights the potential efficacy of allogeneic stem-cell transplantation (allo-SCT) in ETV6::FLT3-positive myeloid/lymphoid neoplasm with eosinophilia. A 33-year-old man presented with lym… (full text at CIViC) PMID 23873282 · Chonabayashi et al., 2014 · Open in CIViC | civic |
| Unmapped disease2unmapped disease | ||||||||
| ETV6::FLT3 Fusion | (functional) | Functional | D | Supports Gain Of Function | 4 | submitted | EID13110This study showed that when HLH domain of ETV6 (also known as TEL) fused to the cytoplasmic domain of the wild-type FLT3 receptor, the fusion caused oligomerization and activation of FLT3. The constit… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available