Publication
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerAcute Myeloid Leukemiacivic_curation1.00
- geneFLT3civic_curation1.00
- variantFLT3 ITDcivic_curation1.00
- variantFLT3 TKD MUTATIONcivic_curation1.00
Curated evidence
Evidence citing this paper (6)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 11290608
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FLT3 D835V1 | ||||||||
| (diagnostic) | Acute Myeloid LeukemiaCURATED_BROADER | Diagnostic | B | Supports Positive | 3 | submitted | EID3011429 AML, 29 MDS, 36 ALL, 14 adult T-Cell leukemia, 17 malignant lymphoma, 10 CLL, 40 multiple myeloma, 11 CML and 3 essential thrombocytosis patients were analyzed for FLT3 gen mutation and FLT3 D835… (full text at CIViC) PMID 11290608 · Yamamoto et al., 2001 · Open in CIViC | civic |
| FLT3 D835Y1 | ||||||||
| (oncogenic) | Acute Myeloid LeukemiaCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID12617Cos7 cells transfected with mutant FLT3 D835Y cDNA demonstrated FLT3 ligand-independent tyrosine phosphorylation. 32D cells stably expressing mutant FLT3 D835Y proliferated without either IL-3 or reco… (full text at CIViC) PMID 11290608 · Yamamoto et al., 2001 · Open in CIViC | civic |
| FLT3 ITD2 | ||||||||
| (diagnostic) | Acute Myeloid LeukemiaCURATED_BROADER | Diagnostic | B | Supports Positive | 3 | accepted | EID222WBC counts were higher in AML patients with internal tandem repeat of Flt3 compared to wild type. PMID 11290608 · Yamamoto et al., 2001 · Open in CIViC | civic |
| (prognostic) | Acute Myeloid LeukemiaCURATED_BROADER | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID371AML patients with internal tandem repeat of FLT3 has worse overall survival than patients with wild type FLT3. PMID 11290608 · Yamamoto et al., 2001 · Open in CIViC | civic |
| FLT3 TKD MUTATION2 | ||||||||
| (diagnostic) | Acute Myeloid LeukemiaCURATED_BROADER | Diagnostic | B | Does Not Support Positive | 3 | accepted | EID214WBC counts were not significantly different in AML patients with FLT3 D835 mutations compared to wild type. PMID 11290608 · Yamamoto et al., 2001 · Open in CIViC | civic |
| (prognostic) | Acute Myeloid LeukemiaCURATED_BROADER | Prognostic | B | Does Not Support N/A | 3 | accepted | EID322AML patients with D835 mutation of FLT3 did not have worse overall survival than patients with wild type FLT3. PMID 11290608 · Yamamoto et al., 2001 · Open in CIViC | civic |