FLT3 G73E

CI-VAR-00001803Explore in graph →NP_004110.2:p.Gly73GluNM_004119.3:c.218G>ACIViC 5184

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Basal Cell Carcinoma1
FLT3 G73E	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID12476 A set of samples from 293 BCCs were sequenced. 263 were sporadic cases and 30 were Gorlin syndrome. 1 sample from patient ID VS069 had FLT3 c.218G>A resulting in G73E. Thie patient sporadic BCC, and w… (full text at CIViC) PMID 26950094 · Bonilla et al., 2016 · Open in CIViC	civic
Chronic Myeloid Leukemia, BCR-ABL1 Positive1
FLT3 G73E	(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	rejected	EID12426 The variant was identified by NGS in a CML (unmatched analysis) (Supplementary File 2). PMID 32943879 · Wu et al., 2020 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Neoplasm1
FLT3 G73E	(oncogenic)	Oncogenic	C	Does Not Support Oncogenicity	2	submitted	EID12425 The variant has been identified in the following tumors. Tumors from the AACR GENIE Project are likely somatic, but most testing was unmatched with a germline sample (https://www.aacr.org/wp-content/… (full text at CIViC) PMID 37668528 · de Bruijn et al., 2023 · Open in CIViC	civic