Malignant Mesothelioma

A novel alternative splice isoform of BAP1 (BAP1Δ) that misses part of the catalytic domain showed reduced deubiquitinating activity compared with full-length BAP1. 4 MPM cell lines expressing more th… (full text at CIViC)

PMID 28389374 · Parrotta et al., 2017 · Open in CIViC

The in vivo experiment demonstrated that Bap1 loss results in increased trimethylated histone H3 lysine 27 (H3K27me3), elevated Ezh2 expression, and enhanced repression of Polycomb Repressive Complex … (full text at CIViC)

PMID 26437366 · LaFave et al., 2015 · Open in CIViC

A siRNA screen identified BAP1 associated with HDAC1 and HDAC2 expression. HDAC2 or BAP1 depletion sensitized a mesothelioma cell line (MSTO-211H) to HDAC inhibitors vorinostat or mocetinostat. The pa… (full text at CIViC)

PMID 25970771 · Sacco et al., 2015 · Open in CIViC

The effect of CDK4/6 inhibitors (abemaciclib or palbociclib) was tested in patient-derived malignant pleural mesothelioma (MLM) cell lines. Of the three patient-derived cell lines, two of the cell lin… (full text at CIViC)

PMID 34588615 · Aliagas et al., 2021 · Open in CIViC

In this study, 23 patients with refractory mesothelioma harbouring germline or somatic BAP1 mutations were treated with olaparib. The median PFS was 3.6 months (95% CI, 2.7-4.2), and the median OS was… (full text at CIViC)

PMID 34661178 · Ghafoor et al., 2021 · Open in CIViC

In this study, 42 patients with malignant pleural or peritoneal mesothelioma were treated with single-agent LY3023414 (Samotolisib). Among the 42 patients, 11 had BAP1 mutations, while SETD2 and NF2 m… (full text at CIViC)

PMID 33660194 · Zauderer et al., 2021 · Open in CIViC

MPM cells transfected with BAP1Δ, an alternative splice isoform of BAP1 that misses part of the catalytic domain, showed reduced deubiquitinating activity compared with full-length BAP1. MPM cell line… (full text at CIViC)

PMID 28389374 · Parrotta et al., 2017 · Open in CIViC

Expression of BRCA1 in 6 mesothelioma cell lines was associated with sensitivity to vinorelbine in functional studies.

PMID 22190288 · Busacca et al., 2012 · Open in CIViC

In this phase 2a clinical trial, 26 patients with either BRCA1-deficient or BAP1-deficient mesotheliomas were treated with Rucaparib. 38% of the patients were BAP1 and BRCA1 negative, 89% were BAP1 ne… (full text at CIViC)

PMID 33515503 · Fennell et al., 2021 · Open in CIViC

A 33 year old M non-smoker with no cancer family history and no known exposure to asbestos showed weakness, chest pain, and plural effusion (PE) accumulation. Mass in right lung was seen under enhance… (full text at CIViC)

PMID 32600123 · Hu et al., 2020 · Open in CIViC

This case report describes a 33 year-old non-smoker with no known exposure to asbestos who was diagnosed with stage IIIB malignant pleural mesothelioma. Panel next generation sequencing (NGS) of 520 g… (full text at CIViC)

PMID 32600123 · Hu et al., 2020 · Open in CIViC

A 33 year old male with no smoking history or known exposure to asbestos was diagnosed with malignant pleural mesothelioma (MPM). EML4::ALK was found using a panel of 520 genes in NGS, and the patient… (full text at CIViC)

PMID 32600123 · Hu et al., 2020 · Open in CIViC

This case report describes a 33 year-old non-smoker with no known exposure to asbestos who was diagnosed with stage IIIB malignant pleural mesothelioma. Panel next generation sequencing (NGS) of 520 g… (full text at CIViC)

PMID 32600123 · Hu et al., 2020 · Open in CIViC

The paper evaluated tissue samples from 73 patients (male and female) for IHC staining of ERCC1 and RRM1. They found that dual expression was associated with later stage MPM and poorer overall surviva… (full text at CIViC)

PMID 32842027 · Zito Marino et al., 2021 · Open in CIViC

FFPE samples from 11 malignant mesothelioma patients were sequenced. In one patient, who was 63 and F, with Epithelioid subtype and Pleural origin, FLT3 S963L was found, together with BCL6 R459C, EP30… (full text at CIViC)

PMID 27127140 · Ugurluer et al., 2016 · Open in CIViC

72 patients with malignant pleural mesothelioma were analyzed, MDM2 immunoexpression was assessed in 65 patients. MDM2 mRNA and protein expression correlated with poor OS and PFS for patients treated … (full text at CIViC)

PMID 25668009 · Walter et al., 2015 · Open in CIViC

72 patients with malignant pleural mesothelioma were analyzed, MDM2 immunoexpression was assessed in 65 patients. MDM2 mRNA and protein expression correlated with poor OS and PFS for patients treated … (full text at CIViC)

PMID 25668009 · Walter et al., 2015 · Open in CIViC

Mice that carried the Q61H variant had Malignant Pleural Mesothelioma and Lewis Lung Carincoma. The malignant cells where taken and each cell line was shown to readily promote lung colonization compar… (full text at CIViC)

PMID 28341702 · Giannou et al., 2017 · Open in CIViC

This is part of a randomised phase 3 trial, CheckpOiNt Blockade For the Inihibition of Relapsed Mesothelioma (CONFIRM), that examined therapeutic response to the anti-PD1 inhibitor, nivolumab, in pati… (full text at CIViC)

PMID 40691143 · Fennell et al., 2025 · Open in CIViC