FLT3 Fusion

CI-VAR-00001533Explore in graph →CIViC 5527

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Myeloproliferative Neoplasm1
ZMYM2::FLT3 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	4	submitted	EID13104 This study reported two cases of myeloproliferative neoplasm with eosinophilia harboring a ZMYM2::FLT3 fusion, which was cytogenetically cryptic and resulted from an approximately 8-Mb inversion. Case… (full text at CIViC) PMID 28751768 · Jawhar et al., 2017 · Open in CIViC	civic
Unmapped disease1unmapped disease
ZMYM2::FLT3 Fusion	(functional)	Functional	D	Supports Gain Of Function	4	submitted	EID13112 This study investigated the rare ZMYM2::FLT3 fusion in myeloid/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions. Here lentiviral vectors containing the fusion gene and negative con… (full text at CIViC) PMID 40767405 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.