B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged

B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FLT3 I8361
(prognostic)	Prognostic	B	Supports Poor Outcome	2	submitted	EID8926 In this study, 162 pediatric ALL patients (50 infants younger than 11 months and 112 children older than 1 year (93 B-cell precursors, 19 T-cell phenotypes)—in addition to 81 healthy donors were analy… (full text at CIViC) PMID 14504097 · Taketani et al., 2004 · Open in CIViC	civic
KMT2A Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12473 In this study, the authors used long-distance inverse PCR and sequencing to comprehensively analyze KMT2A (MLL) gene rearrangements in 2,345 acute leukemia patients, including those with B-lymphoblast… (full text at CIViC) PMID 28701730 · Meyer et al., 2018 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12474 In this publication, the authors conducted a comprehensive genomic analysis of 2,754 pediatric acute lymphoblastic leukemia (ALL) cases using integrated whole genome, exome, and transcriptome sequenci… (full text at CIViC) PMID 36050548 · Brady et al., 2022 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12475 In this publication, the diagnostic significance of KMT2A rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL) is explored. The study reveals that KMT2A fusions are not restricted to lymphoid l…

Data updated 22 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.