FLT3 Y842C

CI-VAR-00004853Explore in graph →CIViC 3070

Curated evidence

Evidence by cancer (10 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–10 of 10 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia7
FLT3 Y842C	FLT3/ABL/Aurora Kinase Inhibitor KW-2449	Predictive	D	Supports Resistance	3	accepted	EID8336 The authors used saturation mutagenesis of FLT3/ITD followed by selection of transfected cells in FLT3 TKI. The FLT3/ITD Y842C mutation produced high-level resistance to KW2449, sorafenib, sunitinib a… (full text at CIViC) PMID 22858906 · Williams et al., 2013 · Open in CIViC	civic
FLT3 Y842C	Lestaurtinib	Predictive	D	Supports Sensitivity Response	4	accepted	EID8339 A screen using saturation mutagenesis of FLT3/ITD followed by selection of transfected TF1 cells in FLT3 TKIs identified Y842C. Cytotoxicity assessed by MTT demonstrated Ba/F3 cells expressing FLT3/IT… (full text at CIViC) PMID 22858906 · Williams et al., 2013 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Neoplasm2
FLT3 ITD AND ( FLT3 D835V OR FLT3 D835Y OR FLT3 Y842C OR FLT3 F691L OR FLT3 Y842H )	Sorafenib	Predictive	D	Supports Resistance	3	submitted	EID12629 In an in-vitro study using an in vitro saturation mutagenesis assay, residues with AC220 (quizartinib) resistance-conferring mutations in the kinase domain of FLT3-ITD were identified. These mutations… (full text at CIViC) PMID 22504184 · Smith et al., 2012 · Open in CIViC	civic
FLT3 ITD AND ( FLT3 Y842C OR FLT3 Y842H )	Quizartinib	Predictive	D	Supports Resistance	3	submitted	EID12628 In an in-vitro study using an in vitro saturation mutagenesis assay, residues with AC220 (quizartinib) resistance-conferring mutations in the kinase domain of FLT3-ITD were identified, including Y842C… (full text at CIViC) PMID 22504184 · Smith et al., 2012 · Open in CIViC	civic

Unmapped disease1unmapped disease
FLT3 Y842C	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID8935 FLT3-Y842C demonstrated constitutive activation of FLT3 and of the downstream molecule STAT-5 in 32D cells overexpressing FLT3-Y842C and in primary AML blasts from an AML patient, suggesting the funct… (full text at CIViC) PMID 15345593 · Kindler et al., 2005 · Open in CIViC	civic