Precursor Lymphoid Neoplasm — Genomics

Precursor Lymphoid Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

7 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acute Lymphoblastic Leukemia - Phase II TARGET-ALL-P2TARGET

768 cases with simple somatic mutation data · 1,587 cases total · Data Release 46.0 · mapped to Acute Lymphoblastic Leukemia ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Acute Lymphoblastic Leukemia - Phase III TARGET-ALL-P3TARGET

108 cases with simple somatic mutation data · 191 cases total · Data Release 46.0 · mapped to Acute Lymphoblastic Leukemia ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	WT1	Ssm	9	108	8.3%	gdc
2	NRAS	Ssm	7	108	6.5%	gdc
3	CREBBP	Ssm	4	108	3.7%	gdc
4	RUNX1	Ssm	4	108	3.7%	gdc
5	MUC4	Ssm	4	108	3.7%	gdc
6	JAK3	Ssm	4	108	3.7%	gdc
8	NSD2	Ssm	3	108	2.8%	gdc
7	LRP1	Ssm	3	108	2.8%	gdc
9	XIRP2	Ssm	3	108	2.8%	gdc
10	SETD2	Ssm	3	108	2.8%	gdc
11	SVEP1	Ssm	3	108	2.8%	gdc
12	CEP295	Ssm	3	108	2.8%	gdc
13	OBSCN	Ssm	3	108	2.8%	gdc
14	GALNT9	Ssm	3	108	2.8%	gdc
15	DDX3X	Ssm	3	108	2.8%	gdc
16	PTPN11	Ssm	3	108	2.8%	gdc
17	AASDH	Ssm	2	108	1.9%	gdc
18	MRPL39	Ssm	2	108	1.9%	gdc
19	PPIL4	Ssm	2	108	1.9%	gdc
20	DYSF	Ssm	2	108	1.9%	gdc
21	HGS	Ssm	2	108	1.9%	gdc
22	SEC23IP	Ssm	2	108	1.9%	gdc
23	DST	Ssm	2	108	1.9%	gdc
24	DRC7	Ssm	2	108	1.9%	gdc
25	HMCN2	Ssm	2	108	1.9%	gdc
26	ASXL1	Ssm	2	108	1.9%	gdc
27	VPS13C	Ssm	2	108	1.9%	gdc
28	SEL1L	Ssm	2	108	1.9%	gdc
29	FAT1	Ssm	2	108	1.9%	gdc
30	PCDHGA3	Ssm	2	108	1.9%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Acute Lymphoblastic Leukemia (St Jude, Nat Genet 2015) all_stjude_2015St Jude

93 cases with simple somatic mutation data · 93 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	12	93	12.9%	cbioportal
2	NRAS	Ssm	8	93	8.6%	cbioportal
3	FLT3	Ssm	5	93	5.4%	cbioportal
5	PIK3CA	Ssm	4	93	4.3%	cbioportal
4	PAX5	Ssm	4	93	4.3%	cbioportal
7	PIK3R1	Ssm	3	93	3.2%	cbioportal
6	NEB	Ssm	3	93	3.2%	cbioportal
14	TTLL4	Ssm	2	93	2.2%	cbioportal
8	CHD7	Ssm	2	93	2.2%	cbioportal
13	TP53	Ssm	2	93	2.2%	cbioportal
12	SLCO3A1	Ssm	2	93	2.2%	cbioportal
11	PDGFRB	Ssm	2	93	2.2%	cbioportal
10	FGF5	Ssm	2	93	2.2%	cbioportal
9	DNHD1	Ssm	2	93	2.2%	cbioportal
23	JAG1	Ssm	1	93	1.1%	cbioportal
15	AXL	Ssm	1	93	1.1%	cbioportal
16	BMAL2	Ssm	1	93	1.1%	cbioportal
17	CREBBP	Ssm	1	93	1.1%	cbioportal
18	DDX10	Ssm	1	93	1.1%	cbioportal
19	ERCC2	Ssm	1	93	1.1%	cbioportal
20	ERCC3	Ssm	1	93	1.1%	cbioportal
21	EZH2	Ssm	1	93	1.1%	cbioportal
22	IGSF9	Ssm	1	93	1.1%	cbioportal
24	MED12	Ssm	1	93	1.1%	cbioportal
25	NF1	Ssm	1	93	1.1%	cbioportal
26	NSD2	Ssm	1	93	1.1%	cbioportal
27	PCDH19	Ssm	1	93	1.1%	cbioportal
28	PCDHGA5	Ssm	1	93	1.1%	cbioportal
29	PDE4B	Ssm	1	93	1.1%	cbioportal
30	PLXNA2	Ssm	1	93	1.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Acute Lymphoblastic Leukemia (St Jude, Nat Genet 2016) all_stjude_2016St Jude

73 cases with simple somatic mutation data · 73 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	18	73	24.7%	cbioportal
2	KMT2D	Ssm	14	73	19.2%	cbioportal
3	SETD2	Ssm	10	73	13.7%	cbioportal
4	TBL1XR1	Ssm	8	73	11%	cbioportal
5	ZFP36L2	Ssm	6	73	8.2%	cbioportal
8	ZEB2	Ssm	5	73	6.8%	cbioportal
7	NCOR1	Ssm	5	73	6.8%	cbioportal
6	KRAS	Ssm	5	73	6.8%	cbioportal
10	PTPN11	Ssm	4	73	5.5%	cbioportal
11	TP53	Ssm	4	73	5.5%	cbioportal
9	PAX5	Ssm	4	73	5.5%	cbioportal
19	TTN	Ssm	3	73	4.1%	cbioportal
17	MYCBP2	Ssm	3	73	4.1%	cbioportal
16	MYC	Ssm	3	73	4.1%	cbioportal
15	MED12	Ssm	3	73	4.1%	cbioportal
14	KDM6A	Ssm	3	73	4.1%	cbioportal
13	ERG	Ssm	3	73	4.1%	cbioportal
12	CTCF	Ssm	3	73	4.1%	cbioportal
18	PIK3R1	Ssm	3	73	4.1%	cbioportal
25	DNAH9	Ssm	2	73	2.7%	cbioportal
20	ABCC8	Ssm	2	73	2.7%	cbioportal
21	ADGRV1	Ssm	2	73	2.7%	cbioportal
22	BRWD1	Ssm	2	73	2.7%	cbioportal
23	CCN3	Ssm	2	73	2.7%	cbioportal
24	DACT2	Ssm	2	73	2.7%	cbioportal
26	EGFR	Ssm	2	73	2.7%	cbioportal
27	EHMT2	Ssm	2	73	2.7%	cbioportal
28	ETV6	Ssm	2	73	2.7%	cbioportal
29	FLT3	Ssm	2	73	2.7%	cbioportal
30	FNDC1	Ssm	2	73	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

B-Lymphoblastic Leukemia/Lymphoma (TARGET GDC, 2025) bll_target_gdcTARGET GDC

739 cases with simple somatic mutation data · 989 cases total · 2026-01-14 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	159	739	21.5%	cbioportal
2	KRAS	Ssm	90	739	12.2%	cbioportal
3	NRAS	Ssm	88	739	11.9%	cbioportal
4	FBXW7	Ssm	59	739	8%	cbioportal
5	PHF6	Ssm	44	739	6%	cbioportal
6	TTN	Ssm	35	739	4.7%	cbioportal
7	PAX5	Ssm	33	739	4.5%	cbioportal
8	KMT2D	Ssm	32	739	4.3%	cbioportal
9	PTEN	Ssm	29	739	3.9%	cbioportal
10	FLT3	Ssm	28	739	3.8%	cbioportal
11	USP7	Ssm	28	739	3.8%	cbioportal
12	DNM2	Ssm	26	739	3.5%	cbioportal
13	CREBBP	Ssm	25	739	3.4%	cbioportal
14	BCL11B	Ssm	24	739	3.2%	cbioportal
15	NSD2	Ssm	23	739	3.1%	cbioportal
16	PTPN11	Ssm	23	739	3.1%	cbioportal
17	JAK2	Ssm	22	739	3%	cbioportal
18	ETV6	Ssm	19	739	2.6%	cbioportal
19	SETD2	Ssm	19	739	2.6%	cbioportal
21	FSIP2	Ssm	17	739	2.3%	cbioportal
20	CTCF	Ssm	17	739	2.3%	cbioportal
22	IKZF1	Ssm	17	739	2.3%	cbioportal
23	TP53	Ssm	17	739	2.3%	cbioportal
24	JAK3	Ssm	16	739	2.2%	cbioportal
25	USH2A	Ssm	16	739	2.2%	cbioportal
27	JAK1	Ssm	15	739	2%	cbioportal
28	ZFHX4	Ssm	15	739	2%	cbioportal
26	IL7R	Ssm	15	739	2%	cbioportal
29	EZH2	Ssm	14	739	1.9%	cbioportal
30	MUC16	Ssm	14	739	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Pediatric Acute Lymphoid Leukemia - Phase II (TARGET, 2018) all_phase2_target_2018_pubTARGET

150 cases with simple somatic mutation data · 1,978 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	16	150	10.7%	cbioportal
2	KRAS	Ssm	8	150	5.3%	cbioportal
4	PTPN11	Ssm	6	150	4%	cbioportal
5	TP53	Ssm	6	150	4%	cbioportal
3	CREBBP	Ssm	6	150	4%	cbioportal
6	FLT3	Ssm	5	150	3.3%	cbioportal
7	JAK2	Ssm	5	150	3.3%	cbioportal
8	NSD2	Ssm	5	150	3.3%	cbioportal
10	NOTCH2	Ssm	4	150	2.7%	cbioportal
9	CDK11A	Ssm	4	150	2.7%	cbioportal
16	TAS2R19	Ssm	3	150	2%	cbioportal
15	QRICH2	Ssm	3	150	2%	cbioportal
11	DOT1L	Ssm	3	150	2%	cbioportal
12	HLA-C	Ssm	3	150	2%	cbioportal
13	KMT2D	Ssm	3	150	2%	cbioportal
14	OVGP1	Ssm	3	150	2%	cbioportal
27	GCNA	Ssm	2	150	1.3%	cbioportal
28	GNB1	Ssm	2	150	1.3%	cbioportal
29	HDHD5	Ssm	2	150	1.3%	cbioportal
30	HLA-DRB1	Ssm	2	150	1.3%	cbioportal
17	APOE	Ssm	2	150	1.3%	cbioportal
18	ATF7IP	Ssm	2	150	1.3%	cbioportal
19	CCDC186	Ssm	2	150	1.3%	cbioportal
20	CEP162	Ssm	2	150	1.3%	cbioportal
21	ECPAS	Ssm	2	150	1.3%	cbioportal
22	ELL	Ssm	2	150	1.3%	cbioportal
23	EZH2	Ssm	2	150	1.3%	cbioportal
24	FCGBP	Ssm	2	150	1.3%	cbioportal
25	FHL3	Ssm	2	150	1.3%	cbioportal
26	FURIN	Ssm	2	150	1.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05