Cancer Family
Precursor Lymphoid Neoplasm
CI-CAN-00000327Explore in graph →
Hematologic567 active trials12 approved drugs212 evidence items
- NCIt
- C7055
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Cancer Family
CI-CAN-00000327Explore in graph →
Genomics
7 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
739 cases with simple somatic mutation data · 989 cases total · 2026-01-14 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NOTCH1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 159 |
| 739 |
| 21.5% |
| cbioportal |
| 2 | KRAS | Ssm | 90 | 739 | 12.2% | cbioportal |
| 3 | NRAS | Ssm | 88 | 739 | 11.9% | cbioportal |
| 4 | FBXW7 | Ssm | 59 | 739 | 8% | cbioportal |
| 5 | PHF6 | Ssm | 44 | 739 | 6% | cbioportal |
| 6 | TTN | Ssm | 35 | 739 | 4.7% | cbioportal |
| 7 | PAX5 | Ssm | 33 | 739 | 4.5% | cbioportal |
| 8 | KMT2D | Ssm | 32 | 739 | 4.3% | cbioportal |
| 9 | PTEN | Ssm | 29 | 739 | 3.9% | cbioportal |
| 10 | FLT3 | Ssm | 28 | 739 | 3.8% | cbioportal |
| 11 | USP7 | Ssm | 28 | 739 | 3.8% | cbioportal |
| 12 | DNM2 | Ssm | 26 | 739 | 3.5% | cbioportal |
| 13 | CREBBP | Ssm | 25 | 739 | 3.4% | cbioportal |
| 14 | BCL11B | Ssm | 24 | 739 | 3.2% | cbioportal |
| 16 | PTPN11 | Ssm | 23 | 739 | 3.1% | cbioportal |
| 15 | NSD2 | Ssm | 23 | 739 | 3.1% | cbioportal |
| 17 | JAK2 | Ssm | 22 | 739 | 3% | cbioportal |
| 18 | ETV6 | Ssm | 19 | 739 | 2.6% | cbioportal |
| 19 | SETD2 | Ssm | 19 | 739 | 2.6% | cbioportal |
| 23 | TP53 | Ssm | 17 | 739 | 2.3% | cbioportal |
| 21 | FSIP2 | Ssm | 17 | 739 | 2.3% | cbioportal |
| 22 | IKZF1 | Ssm | 17 | 739 | 2.3% | cbioportal |
| 20 | CTCF | Ssm | 17 | 739 | 2.3% | cbioportal |
| 25 | USH2A | Ssm | 16 | 739 | 2.2% | cbioportal |
| 24 | JAK3 | Ssm | 16 | 739 | 2.2% | cbioportal |
| 26 | IL7R | Ssm | 15 | 739 | 2% | cbioportal |
| 27 | JAK1 | Ssm | 15 | 739 | 2% | cbioportal |
| 28 | ZFHX4 | Ssm | 15 | 739 | 2% | cbioportal |
| 31 | RYR2 | Ssm | 14 | 739 | 1.9% | cbioportal |
| 29 | EZH2 | Ssm | 14 | 739 | 1.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-14