Myeloid Leukemia — Genomics

Myeloid Leukemia — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

13 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acute Myeloid Leukemia TCGA-LAMLTCGA

200 cases with simple somatic mutation data · 200 cases total · Data Release 46.0 · mapped to Acute Myeloid Leukemia CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VIPR2

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Acute Myeloid Leukemia TARGET-AMLTARGET

836 cases with simple somatic mutation data · 2,492 cases total · Data Release 46.0 · mapped to Acute Myeloid Leukemia CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	POTEG	Ssm	16	836	1.9%	gdc
4	OR4Q3	Ssm	15	836	1.8%	gdc
2	OR4K2	Ssm	15	836	1.8%	gdc
3	OR4M1	Ssm	15	836	1.8%	gdc
5	OR11H2	Ssm	15	836	1.8%	gdc
6	OR4K1	Ssm	15	836	1.8%	gdc
7	POTEM	Ssm	15	836	1.8%	gdc
8	DOC2B	Ssm	15	836	1.8%	gdc
9	OR11H12	Ssm	15	836	1.8%	gdc
10	OR4K5	Ssm	15	836	1.8%	gdc
11	OR4N2	Ssm	15	836	1.8%	gdc
12	LCE3C	Ssm	14	836	1.7%	gdc
13	LCE3B	Ssm	13	836	1.6%	gdc
16	FRG2	Ssm	12	836	1.4%	gdc
15	MBNL1	Ssm	12	836	1.4%	gdc
14	FRG1	Ssm	12	836	1.4%	gdc
19	CHD2	Ssm	10	836	1.2%	gdc
17	ZEB2	Ssm	10	836	1.2%	gdc
21	LYN	Ssm	10	836	1.2%	gdc
20	AC013394.1	Ssm	10	836	1.2%	gdc
18	DUSP10	Ssm	10	836	1.2%	gdc
24	KANSL1	Ssm	9	836	1.1%	gdc
25	RAB2A	Ssm	9	836	1.1%	gdc
26	ZNF596	Ssm	9	836	1.1%	gdc
27	TDRP	Ssm	9	836	1.1%	gdc
28	CD44	Ssm	9	836	1.1%	gdc
29	PTPRC	Ssm	9	836	1.1%	gdc
30	JARID2	Ssm	9	836	1.1%	gdc
22	OR4F21	Ssm	9	836	1.1%	gdc
23	FBXO25	Ssm	9	836	1.1%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Acute Myeloid Leukemia (OHSU, Cancer Cell 2022) aml_ohsu_2022OHSU

903 cases with simple somatic mutation data · 942 cases total · 2026-01-16 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FLT3	Ssm	278	903	30.8%	cbioportal
2	NPM1	Ssm	233	903	25.8%	cbioportal
3	DNMT3A	Ssm	197	903	21.8%	cbioportal
4	NRAS	Ssm	119	903	13.2%	cbioportal
5	TET2	Ssm	118	903	13.1%	cbioportal
6	IDH2	Ssm	111	903	12.3%	cbioportal
7	SRSF2	Ssm	109	903	12.1%	cbioportal
8	RUNX1	Ssm	108	903	12%	cbioportal
9	ASXL1	Ssm	93	903	10.3%	cbioportal
10	TP53	Ssm	82	903	9.1%	cbioportal
11	WT1	Ssm	72	903	8%	cbioportal
12	IDH1	Ssm	71	903	7.9%	cbioportal
13	STAG2	Ssm	60	903	6.6%	cbioportal
14	SF3B1	Ssm	49	903	5.4%	cbioportal
15	BCOR	Ssm	48	903	5.3%	cbioportal
16	CEBPA	Ssm	45	903	5%	cbioportal
17	U2AF1	Ssm	45	903	5%	cbioportal
18	PTPN11	Ssm	44	903	4.9%	cbioportal
19	KRAS	Ssm	43	903	4.8%	cbioportal
20	GATA2	Ssm	37	903	4.1%	cbioportal
21	JAK2	Ssm	36	903	4%	cbioportal
22	PDS5B	Ssm	32	903	3.5%	cbioportal
23	EZH2	Ssm	28	903	3.1%	cbioportal
24	PHF6	Ssm	26	903	2.9%	cbioportal
25	NF1	Ssm	25	903	2.8%	cbioportal
26	RAD21	Ssm	20	903	2.2%	cbioportal
27	CBL	Ssm	19	903	2.1%	cbioportal
28	BCORL1	Ssm	18	903	2%	cbioportal
29	KIT	Ssm	18	903	2%	cbioportal
30	ZRSR2	Ssm	14	903	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Acute Myeloid Leukemia (OHSU, Nature 2018) aml_ohsu_2018OHSU

622 cases with simple somatic mutation data · 672 cases total · 2026-01-05 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FLT3	Ssm	179	622	28.8%	cbioportal
2	DNMT3A	Ssm	139	622	22.3%	cbioportal
3	NPM1	Ssm	135	622	21.7%	cbioportal
4	NRAS	Ssm	77	622	12.4%	cbioportal
5	TET2	Ssm	76	622	12.2%	cbioportal
6	IDH2	Ssm	74	622	11.9%	cbioportal
7	RUNX1	Ssm	74	622	11.9%	cbioportal
8	SRSF2	Ssm	71	622	11.4%	cbioportal
9	WT1	Ssm	56	622	9%	cbioportal
10	IDH1	Ssm	54	622	8.7%	cbioportal
11	TP53	Ssm	54	622	8.7%	cbioportal
12	ASXL1	Ssm	49	622	7.9%	cbioportal
13	BCOR	Ssm	34	622	5.5%	cbioportal
14	CEBPA	Ssm	33	622	5.3%	cbioportal
15	STAG2	Ssm	33	622	5.3%	cbioportal
16	SF3B1	Ssm	32	622	5.1%	cbioportal
17	PTPN11	Ssm	29	622	4.7%	cbioportal
18	U2AF1	Ssm	29	622	4.7%	cbioportal
19	JAK2	Ssm	28	622	4.5%	cbioportal
20	KRAS	Ssm	25	622	4%	cbioportal
21	EZH2	Ssm	22	622	3.5%	cbioportal
22	GATA2	Ssm	22	622	3.5%	cbioportal
23	PHF6	Ssm	18	622	2.9%	cbioportal
24	RAD21	Ssm	16	622	2.6%	cbioportal
25	PDS5B	Ssm	14	622	2.3%	cbioportal
26	BCORL1	Ssm	12	622	1.9%	cbioportal
27	CBL	Ssm	12	622	1.9%	cbioportal
28	ZRSR2	Ssm	12	622	1.9%	cbioportal
29	CSF3R	Ssm	11	622	1.8%	cbioportal
30	KIT	Ssm	11	622	1.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Acute Myeloid Leukemia (TARGET GDC, 2025) aml_target_gdcTARGET GDC

584 cases with simple somatic mutation data · 2,766 cases total · 2026-01-14 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	142	584	24.3%	cbioportal
2	WT1	Ssm	70	584	12%	cbioportal
3	FLT3	Ssm	65	584	11.1%	cbioportal
4	KIT	Ssm	65	584	11.1%	cbioportal
5	NPM1	Ssm	64	584	11%	cbioportal
6	KRAS	Ssm	61	584	10.4%	cbioportal
7	CEBPA	Ssm	37	584	6.3%	cbioportal
8	PTPN11	Ssm	30	584	5.1%	cbioportal
9	TET2	Ssm	28	584	4.8%	cbioportal
10	GATA2	Ssm	25	584	4.3%	cbioportal
11	ASXL2	Ssm	21	584	3.6%	cbioportal
12	SETD2	Ssm	21	584	3.6%	cbioportal
13	RUNX1	Ssm	15	584	2.6%	cbioportal
16	IKZF1	Ssm	14	584	2.4%	cbioportal
14	ETV6	Ssm	14	584	2.4%	cbioportal
15	EZH2	Ssm	14	584	2.4%	cbioportal
18	IDH2	Ssm	13	584	2.2%	cbioportal
17	BCOR	Ssm	13	584	2.2%	cbioportal
19	MYC	Ssm	12	584	2.1%	cbioportal
22	STAG2	Ssm	12	584	2.1%	cbioportal
21	SMC3	Ssm	12	584	2.1%	cbioportal
20	RAD21	Ssm	12	584	2.1%	cbioportal
23	CBL	Ssm	11	584	1.9%	cbioportal
25	PHF6	Ssm	11	584	1.9%	cbioportal
24	CCND3	Ssm	11	584	1.9%	cbioportal
26	CSF3R	Ssm	10	584	1.7%	cbioportal
27	NF1	Ssm	10	584	1.7%	cbioportal
29	TRIM24	Ssm	10	584	1.7%	cbioportal
28	SRCAP	Ssm	10	584	1.7%	cbioportal
30	FAT1	Ssm	9	584	1.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Acute Myeloid Leukemia (TCGA, Firehose Legacy) laml_tcgaTCGA

197 cases with simple somatic mutation data · 200 cases total · 2026-01-07 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FLT3	Ssm	56	197	28.4%	cbioportal
2	NPM1	Ssm	54	197	27.4%	cbioportal
3	DNMT3A	Ssm	51	197	25.9%	cbioportal
4	IDH2	Ssm	20	197	10.2%	cbioportal
5	IDH1	Ssm	19	197	9.6%	cbioportal
6	RUNX1	Ssm	18	197	9.1%	cbioportal
7	TET2	Ssm	17	197	8.6%	cbioportal
8	TP53	Ssm	16	197	8.1%	cbioportal
9	NRAS	Ssm	15	197	7.6%	cbioportal
10	CEBPA	Ssm	13	197	6.6%	cbioportal
11	WT1	Ssm	12	197	6.1%	cbioportal
12	PTPN11	Ssm	9	197	4.6%	cbioportal
14	KRAS	Ssm	8	197	4.1%	cbioportal
13	KIT	Ssm	8	197	4.1%	cbioportal
15	U2AF1	Ssm	8	197	4.1%	cbioportal
16	SMC1A	Ssm	7	197	3.6%	cbioportal
17	SMC3	Ssm	7	197	3.6%	cbioportal
20	TTN	Ssm	6	197	3%	cbioportal
19	STAG2	Ssm	6	197	3%	cbioportal
18	PHF6	Ssm	6	197	3%	cbioportal
22	BRINP3	Ssm	5	197	2.5%	cbioportal
23	RAD21	Ssm	5	197	2.5%	cbioportal
21	ASXL1	Ssm	5	197	2.5%	cbioportal
24	PLCE1	Ssm	4	197	2%	cbioportal
29	CSMD1	Ssm	3	197	1.5%	cbioportal
30	DIS3	Ssm	3	197	1.5%	cbioportal
28	CROCC	Ssm	3	197	1.5%	cbioportal
27	COL12A1	Ssm	3	197	1.5%	cbioportal
26	CACNA1E	Ssm	3	197	1.5%	cbioportal
25	CACNA1B	Ssm	3	197	1.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Acute Myeloid Leukemia (TCGA GDC, 2025) aml_tcga_gdcTCGA GDC

72 cases with simple somatic mutation data · 200 cases total · 2026-01-13 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NPM1	Ssm	8	72	11.1%	cbioportal
3	IDH2	Ssm	5	72	6.9%	cbioportal
2	DNMT3A	Ssm	5	72	6.9%	cbioportal
4	TP53	Ssm	5	72	6.9%	cbioportal
5	RUNX1	Ssm	4	72	5.6%	cbioportal
6	ASXL1	Ssm	3	72	4.2%	cbioportal
10	TTN	Ssm	3	72	4.2%	cbioportal
9	KRAS	Ssm	3	72	4.2%	cbioportal
8	FLT3	Ssm	3	72	4.2%	cbioportal
7	ELF4	Ssm	3	72	4.2%	cbioportal
13	BSN	Ssm	2	72	2.8%	cbioportal
12	BCORL1	Ssm	2	72	2.8%	cbioportal
23	PTPN11	Ssm	2	72	2.8%	cbioportal
22	PHF6	Ssm	2	72	2.8%	cbioportal
21	NR2E1	Ssm	2	72	2.8%	cbioportal
20	NF1	Ssm	2	72	2.8%	cbioportal
19	KIT	Ssm	2	72	2.8%	cbioportal
18	ITPR3	Ssm	2	72	2.8%	cbioportal
17	DNAH11	Ssm	2	72	2.8%	cbioportal
16	CUL1	Ssm	2	72	2.8%	cbioportal
15	CEBPA	Ssm	2	72	2.8%	cbioportal
14	CALR	Ssm	2	72	2.8%	cbioportal
11	ASXL3	Ssm	2	72	2.8%	cbioportal
25	STRIP2	Ssm	2	72	2.8%	cbioportal
24	SCAF8	Ssm	2	72	2.8%	cbioportal
27	ADAMTS18	Ssm	1	72	1.4%	cbioportal
26	ABCB1	Ssm	1	72	1.4%	cbioportal
30	ADGRL4	Ssm	1	72	1.4%	cbioportal
29	ADGRG4	Ssm	1	72	1.4%	cbioportal
28	ADGRF5	Ssm	1	72	1.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Acute Myeloid Leukemia (TCGA, NEJM 2013) laml_tcga_pubTCGA

200 cases with simple somatic mutation data · 200 cases total · 2026-01-07 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FLT3	Ssm	56	200	28%	cbioportal
2	NPM1	Ssm	54	200	27%	cbioportal
3	DNMT3A	Ssm	49	200	24.5%	cbioportal
4	IDH2	Ssm	20	200	10%	cbioportal
5	IDH1	Ssm	19	200	9.5%	cbioportal
7	TET2	Ssm	17	200	8.5%	cbioportal
6	RUNX1	Ssm	17	200	8.5%	cbioportal
8	TP53	Ssm	16	200	8%	cbioportal
9	NRAS	Ssm	15	200	7.5%	cbioportal
10	CEBPA	Ssm	13	200	6.5%	cbioportal
11	WT1	Ssm	12	200	6%	cbioportal
12	PTPN11	Ssm	9	200	4.5%	cbioportal
14	KRAS	Ssm	8	200	4%	cbioportal
13	KIT	Ssm	8	200	4%	cbioportal
15	U2AF1	Ssm	8	200	4%	cbioportal
16	SMC1A	Ssm	7	200	3.5%	cbioportal
17	SMC3	Ssm	7	200	3.5%	cbioportal
18	PHF6	Ssm	6	200	3%	cbioportal
19	STAG2	Ssm	6	200	3%	cbioportal
20	TTN	Ssm	6	200	3%	cbioportal
22	BRINP3	Ssm	5	200	2.5%	cbioportal
21	ASXL1	Ssm	5	200	2.5%	cbioportal
24	RAD21	Ssm	4	200	2%	cbioportal
23	PLCE1	Ssm	4	200	2%	cbioportal
30	DIS3	Ssm	3	200	1.5%	cbioportal
27	COL12A1	Ssm	3	200	1.5%	cbioportal
28	CROCC	Ssm	3	200	1.5%	cbioportal
29	CSMD1	Ssm	3	200	1.5%	cbioportal
25	CACNA1B	Ssm	3	200	1.5%	cbioportal
26	CACNA1E	Ssm	3	200	1.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Acute Myeloid Leukemia (TCGA, PanCancer Atlas) laml_tcga_pan_can_atlas_2018TCGA

200 cases with simple somatic mutation data · 200 cases total · 2026-06-05 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FLT3	Ssm	59	200	29.5%	cbioportal
2	NPM1	Ssm	54	200	27%	cbioportal
3	DNMT3A	Ssm	50	200	25%	cbioportal
4	IDH2	Ssm	21	200	10.5%	cbioportal
5	IDH1	Ssm	19	200	9.5%	cbioportal
6	RUNX1	Ssm	19	200	9.5%	cbioportal
7	TET2	Ssm	17	200	8.5%	cbioportal
8	NRAS	Ssm	16	200	8%	cbioportal
9	TP53	Ssm	16	200	8%	cbioportal
10	TTN	Ssm	14	200	7%	cbioportal
12	WT1	Ssm	13	200	6.5%	cbioportal
11	CEBPA	Ssm	13	200	6.5%	cbioportal
13	BPIFC	Ssm	11	200	5.5%	cbioportal
15	PTPN11	Ssm	10	200	5%	cbioportal
14	KRAS	Ssm	10	200	5%	cbioportal
16	SMC1A	Ssm	9	200	4.5%	cbioportal
17	KIT	Ssm	8	200	4%	cbioportal
19	U2AF1	Ssm	8	200	4%	cbioportal
18	MUC16	Ssm	8	200	4%	cbioportal
20	ASXL1	Ssm	7	200	3.5%	cbioportal
21	HPS3	Ssm	7	200	3.5%	cbioportal
22	PHF6	Ssm	7	200	3.5%	cbioportal
23	SENP6	Ssm	7	200	3.5%	cbioportal
24	SMC3	Ssm	7	200	3.5%	cbioportal
28	DNAH11	Ssm	6	200	3%	cbioportal
30	GABRG3	Ssm	6	200	3%	cbioportal
25	ABCA6	Ssm	6	200	3%	cbioportal
26	BRWD1	Ssm	6	200	3%	cbioportal
27	CSMD1	Ssm	6	200	3%	cbioportal
29	FREM2	Ssm	6	200	3%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Functional Genomic Landscape of Acute Myeloid Leukemia BEATAML1.0-COHORTBEATAML1.0

759 cases with simple somatic mutation data · 826 cases total · Data Release 46.0 · mapped to Acute Myeloid Leukemia CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	DNMT3A	Ssm	33	759	4.3%	gdc
2	NPM1	Ssm	32	759	4.2%	gdc
3	FLT3	Ssm	22	759	2.9%	gdc
4	NRAS	Ssm	20	759	2.6%	gdc
7	TET2	Ssm	19	759	2.5%	gdc
5	IDH1	Ssm	19	759	2.5%	gdc
6	TP53	Ssm	19	759	2.5%	gdc
8	RUNX1	Ssm	18	759	2.4%	gdc
9	WT1	Ssm	15	759	2%	gdc
10	CEBPA	Ssm	15	759	2%	gdc
11	SRSF2	Ssm	14	759	1.8%	gdc
12	IDH2	Ssm	12	759	1.6%	gdc
13	STAG2	Ssm	11	759	1.4%	gdc
15	GATA2	Ssm	10	759	1.3%	gdc
14	BCOR	Ssm	10	759	1.3%	gdc
16	TTN	Ssm	10	759	1.3%	gdc
17	PTPN11	Ssm	9	759	1.2%	gdc
18	EZH2	Ssm	8	759	1.1%	gdc
19	DNAH9	Ssm	8	759	1.1%	gdc
22	SF3B1	Ssm	7	759	0.9%	gdc
21	ASXL1	Ssm	7	759	0.9%	gdc
20	RAD21	Ssm	7	759	0.9%	gdc
27	RYR1	Ssm	6	759	0.8%	gdc
28	PKD1L2	Ssm	6	759	0.8%	gdc
23	CSF3R	Ssm	6	759	0.8%	gdc
24	MUC16	Ssm	6	759	0.8%	gdc
25	SMC3	Ssm	6	759	0.8%	gdc
26	HYDIN	Ssm	6	759	0.8%	gdc
30	DTD2	Ssm	5	759	0.7%	gdc
29	GRIN2B	Ssm	5	759	0.7%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Pediatric Acute Myeloid Leukemia (St. Jude, Nat Genet 2024) aml_stjude_2024St. Jude

887 cases with simple somatic mutation data · 887 cases total · 2026-03-16 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	188	887	21.2%	cbioportal
2	WT1	Ssm	116	887	13.1%	cbioportal
3	KIT	Ssm	88	887	9.9%	cbioportal
4	FLT3	Ssm	79	887	8.9%	cbioportal
5	KRAS	Ssm	78	887	8.8%	cbioportal
6	NPM1	Ssm	67	887	7.6%	cbioportal
7	PTPN11	Ssm	59	887	6.7%	cbioportal
8	CEBPA	Ssm	56	887	6.3%	cbioportal
9	ASXL2	Ssm	29	887	3.3%	cbioportal
10	ZBTB7A	Ssm	29	887	3.3%	cbioportal
11	GATA2	Ssm	27	887	3%	cbioportal
12	NF1	Ssm	26	887	2.9%	cbioportal
13	RUNX1	Ssm	26	887	2.9%	cbioportal
14	IDH2	Ssm	22	887	2.5%	cbioportal
15	SETD2	Ssm	22	887	2.5%	cbioportal
16	RAD21	Ssm	21	887	2.4%	cbioportal
17	TP53	Ssm	18	887	2%	cbioportal
18	GATA1	Ssm	17	887	1.9%	cbioportal
19	KDM6A	Ssm	17	887	1.9%	cbioportal
20	PHF6	Ssm	17	887	1.9%	cbioportal
21	TET2	Ssm	17	887	1.9%	cbioportal
22	CCND3	Ssm	16	887	1.8%	cbioportal
23	ASXL1	Ssm	15	887	1.7%	cbioportal
24	ETV6	Ssm	15	887	1.7%	cbioportal
25	EZH2	Ssm	15	887	1.7%	cbioportal
26	IKZF1	Ssm	15	887	1.7%	cbioportal
27	BCOR	Ssm	14	887	1.6%	cbioportal
28	KMT2C	Ssm	14	887	1.6%	cbioportal
29	MPL	Ssm	14	887	1.6%	cbioportal
30	CTCF	Ssm	13	887	1.5%	cbioportal

Data updated 22 days agoSource updated 2026-03-16

Pediatric Acute Myeloid Leukemia (TARGET, 2018) aml_target_2018_pubTARGET

150 cases with simple somatic mutation data · 1,025 cases total · 2026-01-05 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	22	150	14.7%	cbioportal
2	KIT	Ssm	15	150	10%	cbioportal
3	FLT3	Ssm	10	150	6.7%	cbioportal
4	KRAS	Ssm	9	150	6%	cbioportal
5	PTPN11	Ssm	9	150	6%	cbioportal
6	TET2	Ssm	5	150	3.3%	cbioportal
7	WT1	Ssm	5	150	3.3%	cbioportal
8	CCND2	Ssm	4	150	2.7%	cbioportal
9	CDK11A	Ssm	4	150	2.7%	cbioportal
10	GATA2	Ssm	4	150	2.7%	cbioportal
11	IDH2	Ssm	4	150	2.7%	cbioportal
12	IKZF1	Ssm	4	150	2.7%	cbioportal
13	SLX9	Ssm	4	150	2.7%	cbioportal
14	AKAP9	Ssm	3	150	2%	cbioportal
15	HLA-DQA1	Ssm	3	150	2%	cbioportal
16	NOM1	Ssm	3	150	2%	cbioportal
17	SMC3	Ssm	3	150	2%	cbioportal
18	SORD	Ssm	3	150	2%	cbioportal
19	ARRDC3	Ssm	2	150	1.3%	cbioportal
20	CITED4	Ssm	2	150	1.3%	cbioportal
21	CLASP1	Ssm	2	150	1.3%	cbioportal
22	CSF3R	Ssm	2	150	1.3%	cbioportal
23	CTSH	Ssm	2	150	1.3%	cbioportal
24	CWC27	Ssm	2	150	1.3%	cbioportal
25	DHX15	Ssm	2	150	1.3%	cbioportal
26	EP300	Ssm	2	150	1.3%	cbioportal
27	EZH2	Ssm	2	150	1.3%	cbioportal
28	HLA-C	Ssm	2	150	1.3%	cbioportal
29	IGHMBP2	Ssm	2	150	1.3%	cbioportal
30	JAK2	Ssm	2	150	1.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05