GATA1 — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
GATA1 Mutation1
(diagnostic)	Myeloid Leukemia Associated with Down Syndrome	Diagnostic	A	Supports Positive	5	submitted	EID8511 Children with Down syndrome are at increased risk to developing Transient Abnormal Myelopoiesis (TAM) and Myeloid Leukemia associated with Down Syndrome (ML-DS). GATA1, a gene that encodes an essentia… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic
GATA1 p.Ser51Alafs*861
(prognostic)	Transient Abnormal MyelopoiesisALIAS	Prognostic	C	Supports Better Outcome	2	submitted	EID8302 We report an additional case of twin-to-twin transmission of a TAM clone with identical GATA1 exon 2 mutations in monochorionic-diamniotic twin infants without constitutional T21. This case along with…

Cohorts

Alteration frequency by cohort (40)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved40 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.