Hematologic Malignancy
Myeloid Leukemia
CI-CAN-00001251Explore in graph →
Hematologic862 active trials22 approved drugs599 evidence items
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Hematologic Malignancy
CI-CAN-00001251Explore in graph →
Genomics
13 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
584 cases with simple somatic mutation data · 2,766 cases total · 2026-01-14 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NRAS | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 142 |
| 584 |
| 24.3% |
| cbioportal |
| 2 | WT1 | Ssm | 70 | 584 | 12% | cbioportal |
| 3 | FLT3 | Ssm | 65 | 584 | 11.1% | cbioportal |
| 4 | KIT | Ssm | 65 | 584 | 11.1% | cbioportal |
| 5 | NPM1 | Ssm | 64 | 584 | 11% | cbioportal |
| 6 | KRAS | Ssm | 61 | 584 | 10.4% | cbioportal |
| 7 | CEBPA | Ssm | 37 | 584 | 6.3% | cbioportal |
| 8 | PTPN11 | Ssm | 30 | 584 | 5.1% | cbioportal |
| 9 | TET2 | Ssm | 28 | 584 | 4.8% | cbioportal |
| 10 | GATA2 | Ssm | 25 | 584 | 4.3% | cbioportal |
| 12 | SETD2 | Ssm | 21 | 584 | 3.6% | cbioportal |
| 11 | ASXL2 | Ssm | 21 | 584 | 3.6% | cbioportal |
| 13 | RUNX1 | Ssm | 15 | 584 | 2.6% | cbioportal |
| 14 | ETV6 | Ssm | 14 | 584 | 2.4% | cbioportal |
| 16 | IKZF1 | Ssm | 14 | 584 | 2.4% | cbioportal |
| 15 | EZH2 | Ssm | 14 | 584 | 2.4% | cbioportal |
| 17 | BCOR | Ssm | 13 | 584 | 2.2% | cbioportal |
| 18 | IDH2 | Ssm | 13 | 584 | 2.2% | cbioportal |
| 21 | SMC3 | Ssm | 12 | 584 | 2.1% | cbioportal |
| 22 | STAG2 | Ssm | 12 | 584 | 2.1% | cbioportal |
| 20 | RAD21 | Ssm | 12 | 584 | 2.1% | cbioportal |
| 19 | MYC | Ssm | 12 | 584 | 2.1% | cbioportal |
| 24 | CCND3 | Ssm | 11 | 584 | 1.9% | cbioportal |
| 23 | CBL | Ssm | 11 | 584 | 1.9% | cbioportal |
| 25 | PHF6 | Ssm | 11 | 584 | 1.9% | cbioportal |
| 29 | TRIM24 | Ssm | 10 | 584 | 1.7% | cbioportal |
| 28 | SRCAP | Ssm | 10 | 584 | 1.7% | cbioportal |
| 26 | CSF3R | Ssm | 10 | 584 | 1.7% | cbioportal |
| 27 | NF1 | Ssm | 10 | 584 | 1.7% | cbioportal |
| 30 | FAT1 | Ssm | 9 | 584 | 1.5% | cbioportal |
Data updated 22 days agoSource updated 2026-01-14