CCND2 — gene · CancerIndex

Curated evidence

Clinical evidence (7)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CCND1 Amplification + CCND2 Amplification + CCND3 AmplificationCCND1 CCND2 CCND31
Palbociclib	Malignant NeoplasmALIAS	Predictive	B	Does Not Support Sensitivity Response	4	accepted	EID11673 This Phase 2 NCI-MATCH Trial subprotocol Z1B was conducted in 32 patients with either CCND1, 2 or 3 amplification, and were treated with Palbociclib. Squamous cell lung cancer (n=5), adenocarcinoma of… (full text at CIViC) PMID 36853016 · Clark et al., 2023 · Open in CIViC	civic
CCND2 Amplification1
Palbociclib	Lung Squamous Cell Carcinoma	Predictive	B	Does Not Support Sensitivity Response

Cohorts

Alteration frequency by cohort (30)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved30 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
IDH-mutated Diffuse Glioma (MSK, Clin Cancer Res 2024) difg_msk_2023	Diffuse Glioma	Ssm	3	73

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Phase II Study of Palbociclib (PD-0332991) in CCND1, 2, or 3 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1B.
· Clin Cancer Res · 2023 · PMID 36853016 · validated civic_curation pubmed
Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis.
· J Pathol · 1999 · PMID 10547574 · validated civic_curation pubmed
Promoter methylation of cyclin D2 gene in gastric carcinoma.
· Int J Oncol · 2003 · PMID 14612939 · validated civic_curation pubmed

CCND2 OVEREXPRESSION4
(prognostic)	Malignant Gastric Neoplasm	Prognostic	D	Supports Poor Outcome	4	accepted	EID359 Cyclin D2 overexpression is associated with poor prognosis in gastric cancers. PMID 10547574 · Takano et al., 1999 · Open in CIViC	civic
〃	Malignant Gastric Neoplasm	Prognostic	D	Supports Poor Outcome	4	accepted	EID360 Cyclin D2 overexpression is associated with the increased depth of cancer invasion in gastric cancers. PMID 10547574 · Takano et al., 1999 · Open in CIViC	civic
〃	Malignant Gastric Neoplasm	Prognostic	D	Supports Poor Outcome	4	accepted	EID361 Cyclin D2 overexpression is associated with the presence pf lymph node metastasis in gastric cancers. PMID 10547574 · Takano et al., 1999 · Open in CIViC	civic
〃	Malignant Gastric Neoplasm	Prognostic	D	Supports Poor Outcome	4	accepted	EID362 Cyclin D2 overexpression is associated with vascular invasion by cancer cells in gastric cancers. PMID 10547574 · Takano et al., 1999 · Open in CIViC	civic