Hematologic Malignancy
Aggressive B-Cell Non-Hodgkin Lymphoma
CI-CAN-00001751Explore in graph →
Hematologic115 active trials4 evidence items
- NCIt
- C178541
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Hematologic Malignancy
CI-CAN-00001751Explore in graph →
Genomics
7 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
263 cases with simple somatic mutation data · 324 cases total · Data Release 46.0 · mapped to Burkitt Lymphoma ONTOLOGY_EXACT
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| SHCBP1 |
| Ssm |
| 73 |
| 263 |
| 27.8% |
| gdc |
| 2 | VPS35 | Ssm | 67 | 263 | 25.5% | gdc |
| 3 | ORC6 | Ssm | 66 | 263 | 25.1% | gdc |
| 4 | TPTE | Ssm | 66 | 263 | 25.1% | gdc |
| 5 | MYLK3 | Ssm | 62 | 263 | 23.6% | gdc |
| 6 | IGLL5 | Ssm | 60 | 263 | 22.8% | gdc |
| 7 | C16orf87 | Ssm | 56 | 263 | 21.3% | gdc |
| 8 | PTPRC | Ssm | 50 | 263 | 19% | gdc |
| 9 | ZNF280B | Ssm | 48 | 263 | 18.3% | gdc |
| 10 | ZNF280A | Ssm | 47 | 263 | 17.9% | gdc |
| 11 | GGTLC2 | Ssm | 46 | 263 | 17.5% | gdc |
| 12 | PRAME | Ssm | 46 | 263 | 17.5% | gdc |
| 13 | MYC | Ssm | 45 | 263 | 17.1% | gdc |
| 14 | OR11H12 | Ssm | 44 | 263 | 16.7% | gdc |
| 15 | ATP6V1G3 | Ssm | 43 | 263 | 16.3% | gdc |
| 16 | SLAMF6 | Ssm | 43 | 263 | 16.3% | gdc |
| 17 | ENSA | Ssm | 40 | 263 | 15.2% | gdc |
| 18 | CD84 | Ssm | 40 | 263 | 15.2% | gdc |
| 19 | GOLPH3L | Ssm | 39 | 263 | 14.8% | gdc |
| 20 | MLLT11 | Ssm | 39 | 263 | 14.8% | gdc |
| 21 | CDC42SE1 | Ssm | 39 | 263 | 14.8% | gdc |
| 22 | ADAMTSL4 | Ssm | 39 | 263 | 14.8% | gdc |
| 23 | GABPB2 | Ssm | 39 | 263 | 14.8% | gdc |
| 24 | TARS2 | Ssm | 39 | 263 | 14.8% | gdc |
| 25 | CD48 | Ssm | 39 | 263 | 14.8% | gdc |
| 26 | C1orf56 | Ssm | 39 | 263 | 14.8% | gdc |
| 27 | ANXA9 | Ssm | 38 | 263 | 14.4% | gdc |
| 28 | MCL1 | Ssm | 38 | 263 | 14.4% | gdc |
| 29 | ECM1 | Ssm | 38 | 263 | 14.4% | gdc |
| 30 | CTSK | Ssm | 38 | 263 | 14.4% | gdc |
Data updated 22 days agoSource updated Data Release 46.0
58 cases with simple somatic mutation data · 58 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PCLO | Ssm | 19 | 58 | 32.8% | cbioportal |
| 2 | BCL2 | Ssm | 15 | 58 | 25.9% | cbioportal |
| 3 | CREBBP | Ssm | 14 | 58 | 24.1% | cbioportal |
| 4 | FAT4 | Ssm | 13 | 58 | 22.4% | cbioportal |
| 5 | TP53 | Ssm | 13 | 58 | 22.4% | cbioportal |
| 6 | KMT2D | Ssm | 12 | 58 | 20.7% | cbioportal |
| 7 | PIM1 | Ssm | 12 | 58 | 20.7% | cbioportal |
| 8 | CARD11 | Ssm | 11 | 58 | 19% | cbioportal |
| 9 | GNA13 | Ssm | 9 | 58 | 15.5% | cbioportal |
| 10 | TENM1 | Ssm | 9 | 58 | 15.5% | cbioportal |
| 12 | CSMD3 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 13 | H1-4 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 14 | MEF2B | Ssm | 8 | 58 | 13.8% | cbioportal |
| 15 | MUC16 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 17 | SGK1 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 18 | TNFRSF14 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 16 | P2RY8 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 11 | BTG1 | Ssm | 8 | 58 | 13.8% | cbioportal |
| 19 | CD79B | Ssm | 7 | 58 | 12.1% | cbioportal |
| 20 | FAT1 | Ssm | 7 | 58 | 12.1% | cbioportal |
| 21 | LRRN3 | Ssm | 7 | 58 | 12.1% | cbioportal |
| 22 | MYD88 | Ssm | 7 | 58 | 12.1% | cbioportal |
| 23 | UNC5D | Ssm | 7 | 58 | 12.1% | cbioportal |
| 27 | BCR | Ssm | 6 | 58 | 10.3% | cbioportal |
| 24 | ABCA13 | Ssm | 6 | 58 | 10.3% | cbioportal |
| 25 | ATRX | Ssm | 6 | 58 | 10.3% | cbioportal |
| 26 | B2M | Ssm | 6 | 58 | 10.3% | cbioportal |
| 28 | BIRC6 | Ssm | 6 | 58 | 10.3% | cbioportal |
| 29 | EZH2 | Ssm | 6 | 58 | 10.3% | cbioportal |
| 30 | H1-2 | Ssm | 6 | 58 | 10.3% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07
135 cases with simple somatic mutation data · 135 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KMT2D | Ssm | 35 | 135 | 25.9% | cbioportal |
| 2 | PCLO | Ssm | 32 | 135 | 23.7% | cbioportal |
| 4 | TP53 | Ssm | 31 | 135 | 23% | cbioportal |
| 3 | PIM1 | Ssm | 31 | 135 | 23% | cbioportal |
| 5 | BCL2 | Ssm | 30 | 135 | 22.2% | cbioportal |
| 6 | CREBBP | Ssm | 28 | 135 | 20.7% | cbioportal |
| 7 | BTG1 | Ssm | 25 | 135 | 18.5% | cbioportal |
| 8 | MYD88 | Ssm | 22 | 135 | 16.3% | cbioportal |
| 9 | CD79B | Ssm | 20 | 135 | 14.8% | cbioportal |
| 10 | FAT4 | Ssm | 20 | 135 | 14.8% | cbioportal |
| 11 | SGK1 | Ssm | 19 | 135 | 14.1% | cbioportal |
| 12 | CARD11 | Ssm | 18 | 135 | 13.3% | cbioportal |
| 13 | TTN | Ssm | 18 | 135 | 13.3% | cbioportal |
| 14 | FAT1 | Ssm | 17 | 135 | 12.6% | cbioportal |
| 15 | TNFRSF14 | Ssm | 17 | 135 | 12.6% | cbioportal |
| 17 | H1-2 | Ssm | 16 | 135 | 11.9% | cbioportal |
| 18 | USH2A | Ssm | 16 | 135 | 11.9% | cbioportal |
| 16 | CSMD3 | Ssm | 16 | 135 | 11.9% | cbioportal |
| 19 | ACTB | Ssm | 15 | 135 | 11.1% | cbioportal |
| 20 | ZFP36L1 | Ssm | 15 | 135 | 11.1% | cbioportal |
| 23 | MUC16 | Ssm | 14 | 135 | 10.4% | cbioportal |
| 21 | H1-4 | Ssm | 14 | 135 | 10.4% | cbioportal |
| 22 | LRP1B | Ssm | 14 | 135 | 10.4% | cbioportal |
| 24 | CD70 | Ssm | 13 | 135 | 9.6% | cbioportal |
| 26 | TBL1XR1 | Ssm | 13 | 135 | 9.6% | cbioportal |
| 25 | SYNE1 | Ssm | 13 | 135 | 9.6% | cbioportal |
| 28 | EBF1 | Ssm | 12 | 135 | 8.9% | cbioportal |
| 27 | BCL6 | Ssm | 12 | 135 | 8.9% | cbioportal |
| 30 | HLA-A | Ssm | 12 | 135 | 8.9% | cbioportal |
| 29 | GNA13 | Ssm | 12 | 135 | 8.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07
1,001 cases with simple somatic mutation data · 1,001 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KMT2D | Ssm | 247 | 1,001 | 24.7% | cbioportal |
| 2 | MYD88 | Ssm | 172 | 1,001 | 17.2% | cbioportal |
| 3 | PIM1 | Ssm | 147 | 1,001 | 14.7% | cbioportal |
| 4 | CREBBP | Ssm | 115 | 1,001 | 11.5% | cbioportal |
| 5 | H1-4 | Ssm | 105 | 1,001 | 10.5% | cbioportal |
| 7 | SPEN | Ssm | 101 | 1,001 | 10.1% | cbioportal |
| 6 | BCL2 | Ssm | 101 | 1,001 | 10.1% | cbioportal |
| 8 | ARID1A | Ssm | 96 | 1,001 | 9.6% | cbioportal |
| 9 | TP53 | Ssm | 93 | 1,001 | 9.3% | cbioportal |
| 10 | SOCS1 | Ssm | 92 | 1,001 | 9.2% | cbioportal |
| 11 | CARD11 | Ssm | 89 | 1,001 | 8.9% | cbioportal |
| 12 | ARID1B | Ssm | 83 | 1,001 | 8.3% | cbioportal |
| 13 | GNA13 | Ssm | 83 | 1,001 | 8.3% | cbioportal |
| 14 | SETD1B | Ssm | 83 | 1,001 | 8.3% | cbioportal |
| 15 | TNFRSF14 | Ssm | 79 | 1,001 | 7.9% | cbioportal |
| 16 | DUSP2 | Ssm | 76 | 1,001 | 7.6% | cbioportal |
| 17 | MGA | Ssm | 75 | 1,001 | 7.5% | cbioportal |
| 18 | SMARCA4 | Ssm | 75 | 1,001 | 7.5% | cbioportal |
| 19 | NOTCH2 | Ssm | 73 | 1,001 | 7.3% | cbioportal |
| 20 | ATM | Ssm | 72 | 1,001 | 7.2% | cbioportal |
| 21 | ZNF608 | Ssm | 68 | 1,001 | 6.8% | cbioportal |
| 22 | KLHL6 | Ssm | 67 | 1,001 | 6.7% | cbioportal |
| 23 | SGK1 | Ssm | 67 | 1,001 | 6.7% | cbioportal |
| 25 | IRF8 | Ssm | 64 | 1,001 | 6.4% | cbioportal |
| 24 | BIRC6 | Ssm | 64 | 1,001 | 6.4% | cbioportal |
| 26 | MTOR | Ssm | 64 | 1,001 | 6.4% | cbioportal |
| 27 | PIK3CD | Ssm | 63 | 1,001 | 6.3% | cbioportal |
| 28 | SETD2 | Ssm | 62 | 1,001 | 6.2% | cbioportal |
| 29 | TET2 | Ssm | 62 | 1,001 | 6.2% | cbioportal |
| 30 | EZH2 | Ssm | 61 | 1,001 | 6.1% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07
36 cases with simple somatic mutation data · 48 cases total · 2026-01-13 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KMT2D | Ssm | 11 | 36 | 30.6% | cbioportal |
| 2 | BTG2 | Ssm | 10 | 36 | 27.8% | cbioportal |
| 4 | PIM1 | Ssm | 8 | 36 | 22.2% | cbioportal |
| 3 | CARD11 | Ssm | 8 | 36 | 22.2% | cbioportal |
| 11 | IGLC2 | Ssm | 7 | 36 | 19.4% | cbioportal |
| 10 | IGHV2-70 | Ssm | 7 | 36 | 19.4% | cbioportal |
| 9 | IGHG2 | Ssm | 7 | 36 | 19.4% | cbioportal |
| 8 | IGHG1 | Ssm | 7 | 36 | 19.4% | cbioportal |
| 7 | H1-4 | Ssm | 7 | 36 | 19.4% | cbioportal |
| 6 | FAT4 | Ssm | 7 | 36 | 19.4% | cbioportal |
| 5 | B2M | Ssm | 7 | 36 | 19.4% | cbioportal |
| 13 | PCLO | Ssm | 7 | 36 | 19.4% | cbioportal |
| 12 | LRP1B | Ssm | 7 | 36 | 19.4% | cbioportal |
| 20 | SOCS1 | Ssm | 6 | 36 | 16.7% | cbioportal |
| 14 | H1-2 | Ssm | 6 | 36 | 16.7% | cbioportal |
| 15 | IGHM | Ssm | 6 | 36 | 16.7% | cbioportal |
| 16 | IGLV3-1 | Ssm | 6 | 36 | 16.7% | cbioportal |
| 17 | ITPKB | Ssm | 6 | 36 | 16.7% | cbioportal |
| 18 | MUC16 | Ssm | 6 | 36 | 16.7% | cbioportal |
| 19 | P2RY8 | Ssm | 6 | 36 | 16.7% | cbioportal |
| 23 | IGLC3 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 21 | ASXL3 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 29 | TP53 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 28 | TMSB4X | Ssm | 5 | 36 | 13.9% | cbioportal |
| 27 | SYNE1 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 26 | STAT3 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 25 | PLCB1 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 24 | IRF4 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 30 | UBR4 | Ssm | 5 | 36 | 13.9% | cbioportal |
| 22 | BTG1 | Ssm | 5 | 36 | 13.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-13
41 cases with simple somatic mutation data · 48 cases total · 2026-06-05 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | IGHV2-70 | Ssm | 18 | 41 | 43.9% | cbioportal |
| 2 | IGLV3-1 | Ssm | 14 | 41 | 34.1% | cbioportal |
| 3 | KMT2D | Ssm | 12 | 41 | 29.3% | cbioportal |
| 4 | BTG2 | Ssm | 10 | 41 | 24.4% | cbioportal |
| 5 | IGLL5 | Ssm | 10 | 41 | 24.4% | cbioportal |
| 6 | B2M | Ssm | 9 | 41 | 22% | cbioportal |
| 7 | IGHV1-69 | Ssm | 9 | 41 | 22% | cbioportal |
| 8 | CARD11 | Ssm | 8 | 41 | 19.5% | cbioportal |
| 9 | IGHG1 | Ssm | 8 | 41 | 19.5% | cbioportal |
| 10 | IGHM | Ssm | 8 | 41 | 19.5% | cbioportal |
| 11 | PIM1 | Ssm | 8 | 41 | 19.5% | cbioportal |
| 19 | TMSB4X | Ssm | 7 | 41 | 17.1% | cbioportal |
| 18 | MYD88 | Ssm | 7 | 41 | 17.1% | cbioportal |
| 17 | LRP1B | Ssm | 7 | 41 | 17.1% | cbioportal |
| 16 | IGHV4-34 | Ssm | 7 | 41 | 17.1% | cbioportal |
| 15 | IGHG2 | Ssm | 7 | 41 | 17.1% | cbioportal |
| 14 | H1-4 | Ssm | 7 | 41 | 17.1% | cbioportal |
| 13 | H1-2 | Ssm | 7 | 41 | 17.1% | cbioportal |
| 12 | FAT4 | Ssm | 7 | 41 | 17.1% | cbioportal |
| 23 | IRF4 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 22 | IGLC2 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 21 | IGKV1-5 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 20 | IGKJ4 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 29 | STAT3 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 28 | SOCS1 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 30 | ZFHX4 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 27 | PCLO | Ssm | 6 | 41 | 14.6% | cbioportal |
| 26 | P2RY8 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 25 | MUC16 | Ssm | 6 | 41 | 14.6% | cbioportal |
| 24 | ITPKB | Ssm | 6 | 41 | 14.6% | cbioportal |
Data updated 22 days agoSource updated 2026-06-05
48 cases with simple somatic mutation data · 48 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | IGLL5 | Ssm | 17 | 48 | 35.4% | cbioportal |
| 2 | MUC4 | Ssm | 15 | 48 | 31.3% | cbioportal |
| 4 | MUC2 | Ssm | 14 | 48 | 29.2% | cbioportal |
| 3 | KMT2D | Ssm | 14 | 48 | 29.2% | cbioportal |
| 6 | BTG2 | Ssm | 13 | 48 | 27.1% | cbioportal |
| 5 | B2M | Ssm | 13 | 48 | 27.1% | cbioportal |
| 7 | MUC16 | Ssm | 11 | 48 | 22.9% | cbioportal |
| 9 | FAT4 | Ssm | 10 | 48 | 20.8% | cbioportal |
| 12 | TTN | Ssm | 10 | 48 | 20.8% | cbioportal |
| 11 | SYNE1 | Ssm | 10 | 48 | 20.8% | cbioportal |
| 10 | PIM1 | Ssm | 10 | 48 | 20.8% | cbioportal |
| 8 | CARD11 | Ssm | 10 | 48 | 20.8% | cbioportal |
| 14 | MUC5B | Ssm | 9 | 48 | 18.8% | cbioportal |
| 13 | H1-4 | Ssm | 9 | 48 | 18.8% | cbioportal |
| 17 | PCLO | Ssm | 8 | 48 | 16.7% | cbioportal |
| 16 | P2RY8 | Ssm | 8 | 48 | 16.7% | cbioportal |
| 15 | CSMD3 | Ssm | 8 | 48 | 16.7% | cbioportal |
| 29 | OBSCN | Ssm | 7 | 48 | 14.6% | cbioportal |
| 30 | RHPN2 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 23 | HLA-C | Ssm | 7 | 48 | 14.6% | cbioportal |
| 22 | H1-2 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 24 | KLHL6 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 20 | DMBT1 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 19 | BTG1 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 18 | ATM | Ssm | 7 | 48 | 14.6% | cbioportal |
| 21 | FAT1 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 25 | LRP1B | Ssm | 7 | 48 | 14.6% | cbioportal |
| 26 | LRP2 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 27 | MUC17 | Ssm | 7 | 48 | 14.6% | cbioportal |
| 28 | MYD88 | Ssm | 7 | 48 | 14.6% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07