Methotrexate

Curated

← predicts response to

NTRK3 Fusionfusion

sensitivity

Curated

← predicts response to

TP53 R273HSNV

resistance

Osteosarcoma

Curated

Methotrexate targets …TARGETS1 of 1
→ targets	DHFR	—	INHIBITOR	—	1	Curated	chembl	graph →

Methotrexate targets …TARGETS1 of 1

→ targets

DHFR

—

INHIBITOR

—

Curated

Methotrexate investigated for …INVESTIGATED_FOR78 of 78show fewer
→ investigated for	Malignant Neoplasmcancer_family 3 source records aggregated	supports	B	Malignant Neoplasm	3	Curated	civic	graph →
→ investigated for	B Lymphoblastic Leukemia/Lymphomahematologic_malignancy	supports	B	B Lymphoblastic Leukemia/Lymphoma	1	Curated	civic	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	4	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Adenomahistology	unknown	4	Adenoma	1	Curated	chembl	graph →
→ investigated for	Meningeal Carcinomatosissubtype	unknown	4	Meningeal Carcinomatosis	1	Curated	chembl	graph →
→ investigated for	Choriocarcinomahistology	unknown	4	Choriocarcinoma	1	Curated	chembl	graph →
→ investigated for	Non-Hodgkin Lymphomahematologic_malignancy	unknown	4	Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	4	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Mycosis Fungoideshematologic_malignancy	unknown	4	Mycosis Fungoides	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	4	Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	B Lymphoblastic Leukemia/Lymphomahematologic_malignancy	supports	C	B Lymphoblastic Leukemia/Lymphoma	1	Curated	civic	graph →
→ investigated for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy	unknown	3	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Gestational Trophoblastic Tumorsubtype	unknown	3	Gestational Trophoblastic Tumor	1	Curated	chembl	graph →
→ investigated for	Choroid Plexus Neoplasmcancer	unknown	3	Choroid Plexus Neoplasm	1	Curated	chembl	graph →
→ investigated for	Urethra Neoplasmsubtype	unknown	3	Urethra Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	3	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	3	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Central Nervous System Neoplasmcancer_family	unknown	3	Central Nervous System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Myelodysplastic Syndromehematologic_malignancy	unknown	3	Myelodysplastic Syndrome	1	Curated	chembl	graph →
→ investigated for	Acute Megakaryoblastic Leukemiahematologic_malignancy	unknown	3	Acute Megakaryoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Erythroid Leukemiahematologic_malignancy	unknown	3	Acute Erythroid Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Myelomonocytic Leukemiahematologic_malignancy	unknown	3	Acute Myelomonocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Monoblastic Leukemiahematologic_malignancy	unknown	3	Acute Monoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Chronic Myelomonocytic Leukemiahematologic_malignancy	unknown	3	Chronic Myelomonocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	T Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	3	T Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Primitive Neuroectodermal Tumorcancer_family	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
→ investigated for	Lymphoid Leukemiahematologic_malignancy	unknown	3	Lymphoid Leukemia	1	Curated	chembl	graph →
→ investigated for	Myeloproliferative Neoplasmhematologic_malignancy	unknown	3	Myeloproliferative Neoplasm	1	Curated	chembl	graph →
→ investigated for	Brain Neoplasmsubtype	unknown	3	Brain Neoplasm	1	Curated	chembl	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy	unknown	3	Anaplastic Large Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Medulloblastomasubtype	unknown	3	Medulloblastoma	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	3	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	3	Leukemia	1	Curated	chembl	graph →
→ investigated for	Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype	unknown	3	Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Curated	chembl	graph →
→ investigated for	Acute Promyelocytic Leukemiahematologic_malignancy	unknown	3	Acute Promyelocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Hodgkin Lymphomahematologic_malignancy	unknown	3	Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Follicular Lymphomahematologic_malignancy	unknown	3	Follicular Lymphoma	1	Curated	chembl	graph →
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	3	Acute Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Biphenotypic Leukemiahematologic_malignancy	unknown	3	Acute Biphenotypic Leukemia	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	3	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Osteosarcomasubtype	unknown	3	Osteosarcoma	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	3	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Molar Pregnancysubtype	unknown	3	Molar Pregnancy	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	3	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Osteosarcomasubtype	supports	D	Osteosarcoma	1	Curated	civic	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	2	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Blastic Plasmacytoid Dendritic Cell Neoplasmhematologic_malignancy	unknown	2	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Curated	chembl	graph →
→ investigated for	Testicular Neoplasmsubtype	unknown	2	Testicular Neoplasm	1	Curated	chembl	graph →
→ investigated for	Plasma Cell Neoplasmhematologic_malignancy	unknown	2	Plasma Cell Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Myelodysplastic/Myeloproliferative Neoplasmhematologic_malignancy	unknown	2	Myelodysplastic/Myeloproliferative Neoplasm	1	Curated	chembl	graph →
→ investigated for	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissuehematologic_malignancy	unknown	2	Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue	1	Curated	chembl	graph →
→ investigated for	Desmoid Fibromatosissubtype	unknown	2	Desmoid Fibromatosis	1	Curated	chembl	graph →
→ investigated for	Adult T-Cell Leukemia/Lymphomahematologic_malignancy	unknown	2	Adult T-Cell Leukemia/Lymphoma	1	Curated	chembl	graph →
→ investigated for	T-Cell Large Granular Lymphocyte Leukemiahematologic_malignancy	unknown	2	T-Cell Large Granular Lymphocyte Leukemia	1	Curated	chembl	graph →
→ investigated for	Ependymomasubtype	unknown	2	Ependymoma	1	Curated	chembl	graph →
→ investigated for	Kidney Neoplasmsubtype	unknown	2	Kidney Neoplasm	1	Curated	chembl	graph →
→ investigated for	Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype	unknown	2	Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Curated	chembl	graph →
→ investigated for	Neuroblastomasubtype	unknown	2	Neuroblastoma	1	Curated	chembl	graph →
→ investigated for	Sezary Syndromehematologic_malignancy	unknown	2	Sezary Syndrome	1	Curated	chembl	graph →
→ investigated for	Polycythemia Verahematologic_malignancy	unknown	2	Polycythemia Vera	1	Curated	chembl	graph →
→ investigated for	Waldenstrom Macroglobulinemiahematologic_malignancy	unknown	2	Waldenstrom Macroglobulinemia	1	Curated	chembl	graph →
→ investigated for	Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Typehematologic_malignancy	unknown	2	Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type	1	Curated	chembl	graph →
→ investigated for	Mantle Cell Lymphomahematologic_malignancy	unknown	2	Mantle Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Merkel Cell Carcinomasubtype	unknown	2	Merkel Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	AIDS-Related Lymphomahematologic_malignancy	unknown	2	AIDS-Related Lymphoma	1	Curated	chembl	graph →
→ investigated for	Juvenile Myelomonocytic Leukemiahematologic_malignancy	unknown	2	Juvenile Myelomonocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Hematopoietic and Lymphoid Cell Neoplasmcancer_family	unknown	2	Hematopoietic and Lymphoid Cell Neoplasm	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	2	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Primary Myelofibrosishematologic_malignancy	unknown	2	Primary Myelofibrosis	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	2	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Malignant Mesotheliomacancer_family	unknown	2	Malignant Mesothelioma	1	Curated	chembl	graph →
→ investigated for	Burkitt Lymphomahematologic_malignancy	unknown	2	Burkitt Lymphoma	1	Curated	chembl	graph →
→ investigated for	Peripheral T-Cell Lymphoma, Not Otherwise Specifiedhematologic_malignancy	unknown	2	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	2	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Plasma Cell Leukemiahematologic_malignancy	unknown	1	Plasma Cell Leukemia	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	1	Melanoma	1	Curated	chembl	graph →

Methotrexate investigated for …INVESTIGATED_FOR78 of 78show fewer

→ investigated for

Malignant Neoplasmcancer_family

3 source records aggregated

supports

Malignant Neoplasm

Curated

→ investigated for

B Lymphoblastic Leukemia/Lymphomahematologic_malignancy

supports

Curated

→ investigated for

Lung Neoplasmcancer_family

unknown

Lung Neoplasm

Curated

→ investigated for

Adenomahistology

unknown

Adenoma

Curated

→ investigated for

Meningeal Carcinomatosissubtype

unknown

Meningeal Carcinomatosis

Curated

→ investigated for

Choriocarcinomahistology

unknown

Choriocarcinoma

Curated

→ investigated for

Non-Hodgkin Lymphomahematologic_malignancy

unknown

Non-Hodgkin Lymphoma

Curated

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

→ investigated for

Mycosis Fungoideshematologic_malignancy

unknown

Mycosis Fungoides

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

Acute Lymphoblastic Leukemia

→ investigated for

Acute Lymphoblastic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

B Lymphoblastic Leukemia/Lymphomahematologic_malignancy

supports

Curated

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

→ investigated for

Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy

unknown

Curated

Gestational Trophoblastic Tumor

→ investigated for

Gestational Trophoblastic Tumorsubtype

unknown

Curated

→ investigated for

Choroid Plexus Neoplasmcancer

unknown

Choroid Plexus Neoplasm

Curated

→ investigated for

Urethra Neoplasmsubtype

unknown

Urethra Neoplasm

Curated

→ investigated for

Cervical Neoplasmsubtype

unknown

Cervical Neoplasm

Curated

→ investigated for

Bladder Neoplasmsubtype

unknown

Bladder Neoplasm

Curated

Central Nervous System Neoplasm

→ investigated for

Central Nervous System Neoplasmcancer_family

unknown

Curated

→ investigated for

Myelodysplastic Syndromehematologic_malignancy

unknown

Myelodysplastic Syndrome

Curated

Acute Megakaryoblastic Leukemia

→ investigated for

Acute Megakaryoblastic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Acute Erythroid Leukemiahematologic_malignancy

unknown

Acute Erythroid Leukemia

Curated

Acute Myelomonocytic Leukemia

→ investigated for

Acute Myelomonocytic Leukemiahematologic_malignancy

unknown

Curated

Acute Monoblastic Leukemia

→ investigated for

Acute Monoblastic Leukemiahematologic_malignancy

unknown

Curated

Chronic Myelomonocytic Leukemia

→ investigated for

Chronic Myelomonocytic Leukemiahematologic_malignancy

unknown

Curated

T Acute Lymphoblastic Leukemia

→ investigated for

T Acute Lymphoblastic Leukemiahematologic_malignancy

unknown

Curated

Primitive Neuroectodermal Tumor

→ investigated for

Primitive Neuroectodermal Tumorcancer_family

unknown

Curated

→ investigated for

Lymphoid Leukemiahematologic_malignancy

unknown

Lymphoid Leukemia

Curated

Myeloproliferative Neoplasm

→ investigated for

Myeloproliferative Neoplasmhematologic_malignancy

unknown

Curated

→ investigated for

Brain Neoplasmsubtype

unknown

Brain Neoplasm

Curated

Anaplastic Large Cell Lymphoma

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

unknown

Curated

→ investigated for

Medulloblastomasubtype

unknown

Medulloblastoma

Curated

→ investigated for

Sarcomacancer_family

unknown

Sarcoma

Curated

→ investigated for

Leukemiacancer_family

unknown

Leukemia

Curated

Chronic Myeloid Leukemia, BCR-ABL1 Positive

→ investigated for

Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype

unknown

Curated

Acute Promyelocytic Leukemia

→ investigated for

Acute Promyelocytic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Hodgkin Lymphomahematologic_malignancy

unknown

Hodgkin Lymphoma

Curated

→ investigated for

Follicular Lymphomahematologic_malignancy

unknown

Follicular Lymphoma

Curated

→ investigated for

Acute Myeloid Leukemiahematologic_malignancy

unknown

Acute Myeloid Leukemia

Curated

Acute Biphenotypic Leukemia

→ investigated for

Acute Biphenotypic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Lymphomacancer_family

unknown

Lymphoma

Curated

→ investigated for

Osteosarcomasubtype

unknown

Osteosarcoma

Curated

→ investigated for

Head and Neck Neoplasmcancer_family

unknown

Head and Neck Neoplasm

Curated

→ investigated for

Molar Pregnancysubtype

unknown

Molar Pregnancy

Curated

→ investigated for

Squamous Cell Carcinomahistology

unknown

Squamous Cell Carcinoma

Curated

→ investigated for

Osteosarcomasubtype

supports

Osteosarcoma

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Colorectal Neoplasm

Curated

Blastic Plasmacytoid Dendritic Cell Neoplasm

→ investigated for

Blastic Plasmacytoid Dendritic Cell Neoplasmhematologic_malignancy

unknown

Curated

→ investigated for

Testicular Neoplasmsubtype

unknown

Testicular Neoplasm

Curated

→ investigated for

Plasma Cell Neoplasmhematologic_malignancy

unknown

Plasma Cell Neoplasm

Curated

Lung Non-Small Cell Carcinoma

→ investigated for

Lung Non-Small Cell Carcinomasubtype

unknown

Curated

Myelodysplastic/Myeloproliferative Neoplasm

→ investigated for

Myelodysplastic/Myeloproliferative Neoplasmhematologic_malignancy

unknown

Curated

Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

→ investigated for

Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissuehematologic_malignancy

unknown

Curated

→ investigated for

Desmoid Fibromatosissubtype

unknown

Desmoid Fibromatosis

Curated

Adult T-Cell Leukemia/Lymphoma

→ investigated for

Adult T-Cell Leukemia/Lymphomahematologic_malignancy

unknown

Curated

T-Cell Large Granular Lymphocyte Leukemia

→ investigated for

T-Cell Large Granular Lymphocyte Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Ependymomasubtype

unknown

Ependymoma

Curated

→ investigated for

Kidney Neoplasmsubtype

unknown

Kidney Neoplasm

Curated

Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

→ investigated for

Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype

unknown

Curated

→ investigated for

Neuroblastomasubtype

unknown

Neuroblastoma

Curated

→ investigated for

Sezary Syndromehematologic_malignancy

unknown

Sezary Syndrome

Curated

→ investigated for

Polycythemia Verahematologic_malignancy

unknown

Polycythemia Vera

Curated

Waldenstrom Macroglobulinemia

→ investigated for

Waldenstrom Macroglobulinemiahematologic_malignancy

unknown

Curated

Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type

→ investigated for

Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Typehematologic_malignancy

unknown

Curated

→ investigated for

Mantle Cell Lymphomahematologic_malignancy

unknown

Mantle Cell Lymphoma

Curated

→ investigated for

Merkel Cell Carcinomasubtype

unknown

Merkel Cell Carcinoma

Curated

→ investigated for

AIDS-Related Lymphomahematologic_malignancy

unknown

AIDS-Related Lymphoma

Curated

Juvenile Myelomonocytic Leukemia

→ investigated for

Juvenile Myelomonocytic Leukemiahematologic_malignancy

unknown

Curated

Hematopoietic and Lymphoid Cell Neoplasm

→ investigated for

Hematopoietic and Lymphoid Cell Neoplasmcancer_family

unknown

Curated

→ investigated for

Multiple Myelomahematologic_malignancy

unknown

Multiple Myeloma

Curated

→ investigated for

Primary Myelofibrosishematologic_malignancy

unknown

Primary Myelofibrosis

Curated

→ investigated for

Ovarian Neoplasmsubtype

unknown

Ovarian Neoplasm

Curated

→ investigated for

Malignant Mesotheliomacancer_family

unknown

Malignant Mesothelioma

Curated

→ investigated for

Burkitt Lymphomahematologic_malignancy

unknown

Burkitt Lymphoma

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated for

Peripheral T-Cell Lymphoma, Not Otherwise Specifiedhematologic_malignancy

unknown

Curated

Chronic Lymphocytic Leukemia

→ investigated for

Chronic Lymphocytic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Plasma Cell Leukemiahematologic_malignancy

unknown

Plasma Cell Leukemia

Curated

→ investigated for

Melanomacancer_family

unknown

Melanoma

Curated

Methotrexate investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 276show all (up to 200)
→ investigated in trials for	Leukemiacancer_family 163 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	163	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 113 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	113	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemiahematologic_malignancy 107 trials (35 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	107	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic Syndromehematologic_malignancy 82 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic Syndrome	82	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasmcancer_family 43 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	43	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemiahematologic_malignancy 35 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	35	Observed	clinicaltrials	graph →
→ investigated in trials for	B Acute Lymphoblastic Leukemia 27 trials (17 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B Acute Lymphoblastic Leukemia	27	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood Acute Lymphoblastic Leukemia 27 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood Acute Lymphoblastic Leukemia	27	Observed	clinicaltrials	graph →
→ investigated in trials for	Myeloproliferative Neoplasmhematologic_malignancy 25 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myeloproliferative Neoplasm	25	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic/Myeloproliferative Neoplasmhematologic_malignancy 24 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic/Myeloproliferative Neoplasm	24	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Lymphoblastic Leukemia 23 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Lymphoblastic Leukemia	23	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphoblastic Lymphoma 22 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoblastic Lymphoma	22	Observed	clinicaltrials	graph →
→ investigated in trials for	Primary Central Nervous System Lymphoma 22 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Central Nervous System Lymphoma	22	Observed	clinicaltrials	graph →
→ investigated in trials for	Non-Hodgkin Lymphomahematologic_malignancy 21 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Hodgkin Lymphoma	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasmcancer_family 17 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	17	Observed	clinicaltrials	graph →

Methotrexate investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 276show all (up to 200)

→ investigated in trials for

Leukemiacancer_family

163 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Leukemia

163

Observed

→ investigated in trials for

Lymphomacancer_family

113 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Lymphoma

113

Observed

Acute Lymphoblastic Leukemia

→ investigated in trials for

Acute Lymphoblastic Leukemiahematologic_malignancy

107 trials (35 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

107

Observed

→ investigated in trials for

Myelodysplastic Syndromehematologic_malignancy

82 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Myelodysplastic Syndrome

Observed

Malignant Breast Neoplasm

→ investigated in trials for

Malignant Breast Neoplasmcancer_family

43 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Acute Myeloid Leukemiahematologic_malignancy

35 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Acute Myeloid Leukemia

Observed

B Acute Lymphoblastic Leukemia

→ investigated in trials for

27 trials (17 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

B Acute Lymphoblastic Leukemia

Observed

Childhood Acute Lymphoblastic Leukemia

→ investigated in trials for

27 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Childhood Acute Lymphoblastic Leukemia

Observed

Myeloproliferative Neoplasm

→ investigated in trials for

Myeloproliferative Neoplasmhematologic_malignancy

25 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Myelodysplastic/Myeloproliferative Neoplasm

→ investigated in trials for

Myelodysplastic/Myeloproliferative Neoplasmhematologic_malignancy

24 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Adult Acute Lymphoblastic Leukemia

→ investigated in trials for

23 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Adult Acute Lymphoblastic Leukemia

Observed

→ investigated in trials for

Lymphoblastic Lymphoma

22 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Lymphoblastic Lymphoma

Observed

Primary Central Nervous System Lymphoma

→ investigated in trials for

22 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Primary Central Nervous System Lymphoma

Observed

→ investigated in trials for

Non-Hodgkin Lymphomahematologic_malignancy

21 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Non-Hodgkin Lymphoma

Observed

Hematopoietic and Lymphoid Cell Neoplasm

→ investigated in trials for

Hematopoietic and Lymphoid Cell Neoplasmcancer_family

17 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Renal Pelvis and Ureter Urothelial Carcinoma

Methotrexate studied in …STUDIED_INderived10 of 728show all (up to 200)
→ studied in	NCT04628767Phase 2/Phase 3 · recruiting Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer · 728 trials list this drug (131 active)	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05691478Phase 2/Phase 3 · suspended A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma · 728 trials list this drug (131 active)	—	—	Osteosarcoma,Secondary Osteosarcoma,High Grade Osteosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06124157Phase 2 · recruiting A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) · 728 trials list this drug (131 active)	—	—	B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03779854Phase 2 · active not recruiting Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant · 728 trials list this drug (131 active)	—	—	Acute Leukemia,Acute Lymphoblastic Leukemia,Burkitt Leukemia+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05663866Phase 2 · active not recruiting Premedication to Reduce Amivantamab Associated Infusion Related Reactions · 728 trials list this drug (131 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06317662Phase 2 · recruiting Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia · 728 trials list this drug (131 active)	—	—	Acute Leukemia of Ambiguous Lineage,B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07560826Phase 2 · recruiting The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · 728 trials list this drug (131 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05645718Phase 2 · recruiting Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia · 728 trials list this drug (131 active)	—	—	Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07015242Phase 2 · recruiting A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma · 728 trials list this drug (131 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02003222Phase 3 · active not recruiting Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia · 728 trials list this drug (131 active)	—	—	Acute Lymphoblastic Leukemia,B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative	1	Observed	clinicaltrials	graph →

Methotrexate studied in …STUDIED_INderived10 of 728show all (up to 200)

→ studied in

NCT04628767Phase 2/Phase 3 · recruiting

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer · 728 trials list this drug (131 active)

—

Observed

Osteosarcoma,Secondary Osteosarcoma,High Grade Osteosarcoma

→ studied in

NCT05691478Phase 2/Phase 3 · suspended

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma · 728 trials list this drug (131 active)

—

Observed

B Acute Lymphoblastic Leukemia

→ studied in

NCT06124157Phase 2 · recruiting

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) · 728 trials list this drug (131 active)

—

Observed

Acute Leukemia,Acute Lymphoblastic Leukemia,Burkitt Leukemia+2

→ studied in

NCT03779854Phase 2 · active not recruiting

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant · 728 trials list this drug (131 active)

—

Observed

Lung Non-Small Cell Carcinoma

→ studied in

NCT05663866Phase 2 · active not recruiting

Premedication to Reduce Amivantamab Associated Infusion Related Reactions · 728 trials list this drug (131 active)

—

Observed

Acute Leukemia of Ambiguous Lineage,B Acute Lymphoblastic Leukemia

→ studied in

NCT06317662Phase 2 · recruiting

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia · 728 trials list this drug (131 active)

—

Observed

→ studied in

NCT07560826Phase 2 · recruiting

The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma · 728 trials list this drug (131 active)

—

not mapped

Observed

→ studied in

NCT05645718Phase 2 · recruiting

Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia · 728 trials list this drug (131 active)

—

Leukemia

Observed

→ studied in

NCT07015242Phase 2 · recruiting

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma · 728 trials list this drug (131 active)

—

Lymphoma

Observed

Acute Lymphoblastic Leukemia,B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

→ studied in

NCT02003222Phase 3 · active not recruiting

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia · 728 trials list this drug (131 active)

—

Observed