Hematologic Malignancy
Acute Promyelocytic Leukemia
CI-CAN-00008681APL · APMLExplore in graph →
Hematologic14 active trials2 approved drugs16 evidence items
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Hematologic Malignancy
CI-CAN-00008681APL · APMLExplore in graph →
Data completeness4 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
An acute myeloid leukemia characterized by the predominance of abnormal promyelocytes and translocations involving the retinoic acid receptor-alpha (RARA) gene. Over 95% of cases are characterized by the presence of the reciprocal balanced translocation t(15;17)(q24.1;q21.2) that results in the fusion of the promyelocytic leukemia (PML) gene and RARA gene. The remainder of the cases show variant RARA gene translocations with other genes including NUMA1, ZBTB16, STAT5B, and NPM1.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Parents
Children (6)
17 descendants in total; counters on this page aggregate over all of them.
Anatomy
Data updated 18 hours agoSource updated unknowncounters aggregate over descendants
Names
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Key figures
Each figure carries its unit, period and source; ranks link to "Why this rank?".
Data updated 18 hours agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants