Fluorouracil

Curated

← predicts response to

DPYD DPYD*13 HOMOZYGOSITYSNV

unknown

Curated

← predicts response to

DPYD DPYD*2A HOMOZYGOSITYsplice

unknown

Curated

Malignant Gastric Neoplasm,Rectal Carcinoma

← predicts response to

MTHFR A222VSNV

2 source records aggregated

sensitivity

Curated

← predicts response to

HSPH1 T17 DELETIONdeletion

sensitivity

Curated

← predicts response to

CDKN1B EXPRESSIONexpression

sensitivity

Curated

← predicts response to

VEGFA Decreased Peri-therapeutic Expressionexpression

sensitivity

Curated

Esophageal Squamous Cell Carcinoma

← predicts response to

AURKA EXPRESSIONexpression

sensitivity

Curated

← predicts response to

SMAD4 Deletiondeletion_cna

resistance

Curated

← predicts response to

ALCAM EXPRESSIONexpression

resistance

Curated

← predicts response to

CDKN1A EXPRESSIONexpression

resistance

Curated

← predicts response to

DKK1 NUCLEAR EXPRESSIONexpression

resistance

Curated

← predicts response to

TYMS 3TRP/3TRP genotype

resistance

Curated

Malignant Esophageal Neoplasm

← predicts response to

GNAS c.393T>CSNV

resistance

Curated

← predicts response to

HSPA5 EXPRESSIONexpression

sensitivity

Curated

Fluorouracil targets …TARGETS1 of 1
→ targets	TYMS	—	INHIBITOR	—	1	Curated	chembl	graph →

Fluorouracil targets …TARGETS1 of 1

→ targets

TYMS

—

INHIBITOR

—

Curated

Fluorouracil investigated for …INVESTIGATED_FOR73 of 73show fewer
→ investigated for	Malignant Neoplasmcancer_family 3 source records aggregated	supports	A	Malignant Neoplasm	3	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 8 source records aggregated	supports	B	Malignant Colorectal Neoplasm	8	Curated	civic	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype	supports	B	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Esophageal Squamous Cell Carcinomasubtype	supports	B	Esophageal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Gastric Neoplasmcancer	supports	B	Malignant Gastric Neoplasm	1	Curated	civic	graph →
→ investigated for	Malignant Esophageal Neoplasmcancer	supports	B	Malignant Esophageal Neoplasm	1	Curated	civic	graph →
→ investigated for	Rectal Carcinomasubtype	supports	B	Rectal Carcinoma	1	Curated	civic	graph →
→ investigated for	Basal Cell Carcinomahistology	unknown	4	Basal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Adenocarcinomahistology	unknown	4	Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	C	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype	supports	C	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Intestinal Neoplasmcancer_family	unknown	3	Intestinal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Nasopharyngeal Carcinomasubtype	unknown	3	Nasopharyngeal Carcinoma	1	Curated	chembl	graph →
→ investigated for	Oral Cavity Neoplasmsubtype	unknown	3	Oral Cavity Neoplasm	1	Curated	chembl	graph →
→ investigated for	Paranasal Sinus Neoplasmsubtype	unknown	3	Paranasal Sinus Neoplasm	1	Curated	chembl	graph →
→ investigated for	Pharyngeal Neoplasmsubtype	unknown	3	Pharyngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	3	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Liver Neoplasmsubtype	unknown	3	Liver Neoplasm	1	Curated	chembl	graph →
→ investigated for	Kidney Neoplasmsubtype	unknown	3	Kidney Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neuroendocrine Carcinomasubtype	unknown	3	Neuroendocrine Carcinoma	1	Curated	chembl	graph →
→ investigated for	Hypopharyngeal Neoplasmsubtype	unknown	3	Hypopharyngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	3	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Inflammatory Carcinomasubtype	unknown	3	Breast Inflammatory Carcinoma	1	Curated	chembl	graph →
→ investigated for	Hepatoblastomacancer_family	unknown	3	Hepatoblastoma	1	Curated	chembl	graph →
→ investigated for	Cervical Intraepithelial Neoplasiaprecursor_condition	unknown	3	Cervical Intraepithelial Neoplasia	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	3	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cholangiocarcinomasubtype	unknown	3	Cholangiocarcinoma	1	Curated	chembl	graph →
→ investigated for	Colon Neoplasmsubtype	unknown	3	Colon Neoplasm	1	Curated	chembl	graph →
→ investigated for	Laryngeal Neoplasmsubtype	unknown	3	Laryngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Anal Neoplasmsubtype	unknown	3	Anal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	3	Carcinoma	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	3	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	3	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	3	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Rectal Neoplasmsubtype	unknown	3	Rectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Nasopharyngeal Neoplasmsubtype	unknown	3	Nasopharyngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	3	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	3	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	3	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Adenocarcinomasubtype	supports	D	Gastric Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Pancreatic Adenocarcinomasubtype	supports	D	Pancreatic Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family	supports	D	Malignant Neoplasm	1	Curated	civic	graph →
→ investigated for	Neuroendocrine Tumorsubtype	unknown	2	Neuroendocrine Tumor	1	Curated	chembl	graph →
→ investigated for	Gallbladder Neoplasmsubtype	unknown	2	Gallbladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hilar Cholangiocarcinomasubtype	unknown	2	Hilar Cholangiocarcinoma	1	Curated	chembl	graph →
→ investigated for	Bile Duct Neoplasmsubtype	unknown	2	Bile Duct Neoplasm	1	Curated	chembl	graph →
→ investigated for	Skin Neoplasmcancer_family	unknown	2	Skin Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	2	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype	unknown	2	Head and Neck Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Urethra Neoplasmsubtype	unknown	2	Urethra Neoplasm	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neuroendocrine Carcinomasubtype	unknown	2	Pancreatic Neuroendocrine Carcinoma	1	Curated	chembl	graph →
→ investigated for	Digestive System Neoplasmcancer_family	unknown	2	Digestive System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Merkel Cell Carcinomasubtype	unknown	2	Merkel Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Peritoneal Neoplasmcancer_family	unknown	2	Peritoneal Neoplasm	1	Curated	chembl	graph →
→ investigated for	AIDS-Related Lymphomahematologic_malignancy	unknown	2	AIDS-Related Lymphoma	1	Curated	chembl	graph →
→ investigated for	Uterine Neoplasmsubtype	unknown	2	Uterine Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Plasma Cell Neoplasmhematologic_malignancy	unknown	1	Plasma Cell Neoplasm	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	1	Leukemia	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	1	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →
→ investigated for	Gastrointestinal Stromal Tumorsubtype	unknown	1	Gastrointestinal Stromal Tumor	1	Curated	chembl	graph →
→ investigated for	Fallopian Tube Neoplasmsubtype	unknown	1	Fallopian Tube Neoplasm	1	Curated	chembl	graph →
→ investigated for	Myeloproliferative Neoplasmhematologic_malignancy	unknown	1	Myeloproliferative Neoplasm	1	Curated	chembl	graph →
→ investigated for	Non-Hodgkin Lymphomahematologic_malignancy	unknown	1	Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Gliomasubtype	unknown	1	Glioma	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	1	Melanoma	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	1	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Renal Cell Carcinomasubtype	unknown	1	Renal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Myelodysplastic Syndromehematologic_malignancy	unknown	1	Myelodysplastic Syndrome	1	Curated	chembl	graph →
→ investigated for	Ependymomasubtype	unknown	1	Ependymoma	1	Curated	chembl	graph →

Fluorouracil investigated for …INVESTIGATED_FOR73 of 73show fewer

→ investigated for

Malignant Neoplasmcancer_family

3 source records aggregated

supports

Curated

→ investigated for

Malignant Colorectal Neoplasmsubtype

8 source records aggregated

supports

Curated

→ investigated for

supports

Curated

Esophageal Squamous Cell Carcinoma

→ investigated for

Esophageal Squamous Cell Carcinomasubtype

supports

Curated

Malignant Gastric Neoplasm

→ investigated for

Malignant Gastric Neoplasmcancer

supports

Curated

Malignant Esophageal Neoplasm

→ investigated for

Malignant Esophageal Neoplasmcancer

supports

Curated

→ investigated for

Rectal Carcinomasubtype

supports

Rectal Carcinoma

Curated

→ investigated for

Basal Cell Carcinomahistology

unknown

Basal Cell Carcinoma

Curated

→ investigated for

Adenocarcinomahistology

unknown

Adenocarcinoma

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

→ investigated for

Malignant Colorectal Neoplasmsubtype

supports

Curated

→ investigated for

supports

Curated

→ investigated for

Intestinal Neoplasmcancer_family

unknown

Intestinal Neoplasm

Curated

→ investigated for

Nasopharyngeal Carcinomasubtype

unknown

Nasopharyngeal Carcinoma

Curated

→ investigated for

Oral Cavity Neoplasmsubtype

unknown

Oral Cavity Neoplasm

Curated

→ investigated for

Paranasal Sinus Neoplasmsubtype

unknown

Paranasal Sinus Neoplasm

Curated

→ investigated for

Pharyngeal Neoplasmsubtype

unknown

Pharyngeal Neoplasm

Curated

→ investigated for

Cervical Neoplasmsubtype

unknown

Cervical Neoplasm

Curated

→ investigated for

Liver Neoplasmsubtype

unknown

Liver Neoplasm

Curated

→ investigated for

Kidney Neoplasmsubtype

unknown

Kidney Neoplasm

Curated

→ investigated for

Neuroendocrine Carcinomasubtype

unknown

Neuroendocrine Carcinoma

Curated

→ investigated for

Hypopharyngeal Neoplasmsubtype

unknown

Hypopharyngeal Neoplasm

Curated

→ investigated for

Bladder Neoplasmsubtype

unknown

Bladder Neoplasm

Curated

Breast Inflammatory Carcinoma

→ investigated for

Breast Inflammatory Carcinomasubtype

unknown

Curated

→ investigated for

Hepatoblastomacancer_family

unknown

Hepatoblastoma

Curated

Cervical Intraepithelial Neoplasia

→ investigated for

Cervical Intraepithelial Neoplasiaprecursor_condition

unknown

Curated

→ investigated for

Head and Neck Neoplasmcancer_family

unknown

Head and Neck Neoplasm

Curated

→ investigated for

Cholangiocarcinomasubtype

unknown

Cholangiocarcinoma

Curated

→ investigated for

Colon Neoplasmsubtype

unknown

Colon Neoplasm

Curated

→ investigated for

Laryngeal Neoplasmsubtype

unknown

Laryngeal Neoplasm

Curated

→ investigated for

Anal Neoplasmsubtype

unknown

Anal Neoplasm

Curated

→ investigated for

Carcinomacancer_family

unknown

Carcinoma

Curated

→ investigated for

Squamous Cell Carcinomahistology

unknown

Squamous Cell Carcinoma

Curated

→ investigated for

Esophageal Neoplasmcancer_family

unknown

Esophageal Neoplasm

Curated

→ investigated for

Gastric Neoplasmcancer_family

unknown

Gastric Neoplasm

Curated

→ investigated for

Rectal Neoplasmsubtype

unknown

Rectal Neoplasm

Curated

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

→ investigated for

Nasopharyngeal Neoplasmsubtype

unknown

Nasopharyngeal Neoplasm

Curated

→ investigated for

Pancreatic Neoplasmsubtype

unknown

Pancreatic Neoplasm

Curated

→ investigated for

Hepatocellular Carcinomasubtype

unknown

Hepatocellular Carcinoma

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Colorectal Neoplasm

Curated

→ investigated for

Gastric Adenocarcinomasubtype

supports

Gastric Adenocarcinoma

Curated

Pancreatic Adenocarcinoma

→ investigated for

Pancreatic Adenocarcinomasubtype

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

supports

Curated

→ investigated for

Neuroendocrine Tumorsubtype

unknown

Neuroendocrine Tumor

Curated

→ investigated for

Gallbladder Neoplasmsubtype

unknown

Gallbladder Neoplasm

Curated

→ investigated for

Hilar Cholangiocarcinomasubtype

unknown

Hilar Cholangiocarcinoma

Curated

→ investigated for

Bile Duct Neoplasmsubtype

unknown

Bile Duct Neoplasm

Curated

→ investigated for

Skin Neoplasmcancer_family

unknown

Skin Neoplasm

Curated

→ investigated for

Ovarian Neoplasmsubtype

unknown

Ovarian Neoplasm

Curated

→ investigated for

unknown

Curated

→ investigated for

Urethra Neoplasmsubtype

unknown

Urethra Neoplasm

Curated

Pancreatic Neuroendocrine Carcinoma

→ investigated for

Pancreatic Neuroendocrine Carcinomasubtype

unknown

Curated

Digestive System Neoplasm

→ investigated for

Digestive System Neoplasmcancer_family

unknown

Curated

→ investigated for

Merkel Cell Carcinomasubtype

unknown

Merkel Cell Carcinoma

Curated

→ investigated for

Peritoneal Neoplasmcancer_family

unknown

Peritoneal Neoplasm

Curated

→ investigated for

AIDS-Related Lymphomahematologic_malignancy

unknown

AIDS-Related Lymphoma

Curated

→ investigated for

Uterine Neoplasmsubtype

unknown

Uterine Neoplasm

Curated

Lung Non-Small Cell Carcinoma

→ investigated for

Lung Non-Small Cell Carcinomasubtype

unknown

Curated

→ investigated for

Plasma Cell Neoplasmhematologic_malignancy

unknown

Plasma Cell Neoplasm

Curated

→ investigated for

Leukemiacancer_family

unknown

Leukemia

Curated

Triple-Negative Breast Carcinoma

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

unknown

Curated

Gastrointestinal Stromal Tumor

→ investigated for

Gastrointestinal Stromal Tumorsubtype

unknown

Curated

→ investigated for

Fallopian Tube Neoplasmsubtype

unknown

Fallopian Tube Neoplasm

Curated

Myeloproliferative Neoplasm

→ investigated for

Myeloproliferative Neoplasmhematologic_malignancy

unknown

Curated

→ investigated for

Non-Hodgkin Lymphomahematologic_malignancy

unknown

Non-Hodgkin Lymphoma

Curated

→ investigated for

Gliomasubtype

unknown

Glioma

Curated

→ investigated for

Melanomacancer_family

unknown

Melanoma

Curated

→ investigated for

Multiple Myelomahematologic_malignancy

unknown

Multiple Myeloma

Curated

→ investigated for

Lymphomacancer_family

unknown

Lymphoma

Curated

→ investigated for

Renal Cell Carcinomasubtype

unknown

Renal Cell Carcinoma

Curated

→ investigated for

Myelodysplastic Syndromehematologic_malignancy

unknown

Myelodysplastic Syndrome

Curated

→ investigated for

Ependymomasubtype

unknown

Ependymoma

Curated

Fluorouracil investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 283show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 320 trials (50 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	320	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 115 trials (26 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	115	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasmcancer 105 trials (24 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	105	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 83 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	83	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasmcancer 82 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	82	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 79 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	79	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Head and Neck Neoplasm 58 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Head and Neck Neoplasm	58	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 52 trials (17 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	52	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastroesophageal Junction Adenocarcinoma 48 trials (17 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastroesophageal Junction Adenocarcinoma	48	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 47 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	47	Observed	clinicaltrials	graph →
→ investigated in trials for	Pancreatic Adenocarcinomasubtype 46 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Pancreatic Adenocarcinoma	46	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasmcancer_family 43 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	43	Observed	clinicaltrials	graph →
→ investigated in trials for	Head and Neck Squamous Cell Carcinomasubtype 33 trials (11 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Head and Neck Squamous Cell Carcinoma	33	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 33 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	33	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastric Adenocarcinomasubtype 30 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastric Adenocarcinoma	30	Observed	clinicaltrials	graph →

Fluorouracil investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 283show all (up to 200)

→ investigated in trials for

Malignant Colorectal Neoplasmsubtype

320 trials (50 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

320

Observed

Malignant Pancreatic Neoplasm

→ investigated in trials for

115 trials (26 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Pancreatic Neoplasm

115

Observed

Malignant Gastric Neoplasm

→ investigated in trials for

Malignant Gastric Neoplasmcancer

105 trials (24 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

105

Observed

Malignant Breast Neoplasm

→ investigated in trials for

83 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Breast Neoplasm

Observed

Malignant Esophageal Neoplasm

→ investigated in trials for

Malignant Esophageal Neoplasmcancer

82 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Malignant Rectal Neoplasm

→ investigated in trials for

79 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Rectal Neoplasm

Observed

Malignant Head and Neck Neoplasm

→ investigated in trials for

58 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Head and Neck Neoplasm

Observed

→ investigated in trials for

Colorectal Neoplasmsubtype

52 trials (17 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Colorectal Neoplasm

Observed

Gastroesophageal Junction Adenocarcinoma

→ investigated in trials for

48 trials (17 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Gastroesophageal Junction Adenocarcinoma

Observed

→ investigated in trials for

Malignant Colon Neoplasm

47 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Colon Neoplasm

Observed

Pancreatic Adenocarcinoma

→ investigated in trials for

Pancreatic Adenocarcinomasubtype

46 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Malignant Neoplasmcancer_family

43 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

33 trials (11 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Solid Neoplasm

33 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

→ investigated in trials for

Gastric Adenocarcinomasubtype

30 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Gastric Adenocarcinoma

Observed

Malignant Head and Neck Neoplasm

Fluorouracil studied in …STUDIED_INderived10 of 1,324show all (up to 200)
→ studied in	NCT03358472Phase 3 · completed Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304) · 1,324 trials list this drug (263 active)	—	—	Malignant Head and Neck Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05329766Phase 2 · active not recruiting A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies · 1,324 trials list this drug (263 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05564377Phase 2 · recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 1,324 trials list this drug (263 active)	—	—	Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05891171Phase 1 · active not recruiting Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers · 1,324 trials list this drug (263 active)	—	—	Malignant Neoplasm,Malignant Esophageal Neoplasm,Malignant Gastric Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT07744126Phase 2 · recruiting A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma · 1,324 trials list this drug (263 active)	—	—	Head and Neck Squamous Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05007106Phase 2 · completed MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) · 1,324 trials list this drug (263 active)	—	—	Esophageal Neoplasm,Gastric Neoplasm,Gallbladder Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT06770582Phase 2 · recruiting Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial · 1,324 trials list this drug (263 active)	—	—	Malignant Bladder Neoplasm,Non-Muscle Invasive Bladder Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06820463Phase 2 · recruiting A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer · 1,324 trials list this drug (263 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06997497Phase 3 · recruiting A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) · 1,324 trials list this drug (263 active)	—	—	Colon Adenocarcinoma,Rectal Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07621718Phase 3 · recruiting Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 ) · 1,324 trials list this drug (263 active)	—	—	Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma,Pancreatic Adenosquamous Carcinoma+1	1	Observed	clinicaltrials	graph →

Fluorouracil studied in …STUDIED_INderived10 of 1,324show all (up to 200)

→ studied in

NCT03358472Phase 3 · completed

Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304) · 1,324 trials list this drug (263 active)

—

Observed

→ studied in

NCT05329766Phase 2 · active not recruiting

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies · 1,324 trials list this drug (263 active)

—

not mapped

Observed

Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2

→ studied in

NCT05564377Phase 2 · recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 1,324 trials list this drug (263 active)

—

Observed

Malignant Neoplasm,Malignant Esophageal Neoplasm,Malignant Gastric Neoplasm+2

→ studied in

NCT05891171Phase 1 · active not recruiting

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers · 1,324 trials list this drug (263 active)

—

Observed

→ studied in

NCT07744126Phase 2 · recruiting

A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma · 1,324 trials list this drug (263 active)

—

Observed

Esophageal Neoplasm,Gastric Neoplasm,Gallbladder Neoplasm+2

→ studied in

NCT05007106Phase 2 · completed

MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) · 1,324 trials list this drug (263 active)

—

Observed

Malignant Bladder Neoplasm,Non-Muscle Invasive Bladder Urothelial Carcinoma

→ studied in

NCT06770582Phase 2 · recruiting

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial · 1,324 trials list this drug (263 active)

—

Observed

→ studied in

NCT06820463Phase 2 · recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer · 1,324 trials list this drug (263 active)

—

Observed

Colon Adenocarcinoma,Rectal Adenocarcinoma

→ studied in

NCT06997497Phase 3 · recruiting

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) · 1,324 trials list this drug (263 active)

—

Observed

Malignant Pancreatic Neoplasm,Pancreatic Adenocarcinoma,Pancreatic Adenosquamous Carcinoma+1

→ studied in

NCT07621718Phase 3 · recruiting

Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 ) · 1,324 trials list this drug (263 active)

—

Observed