Variant · Expression
AURKA EXPRESSION
CI-VAR-00000894Explore in graph →CIViC 158
Curated evidence
Evidence by cancer (3 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25924824
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Esophageal Squamous Cell Carcinoma1 | ||||||||
| AURKA EXPRESSION | Cisplatin + Fluorouracil + Radiation TherapyCombination | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID1653A retrospective study examining the expression of AURKA in tumor samples of 78 esophageal squamous cell carcinoma patients found that positive expression of AURKA (>10% of cells by IHC) was correlated… (full text at CIViC) PMID 25924824 · Tamotsu et al., 2015 · Open in CIViC | civic |
| Ovarian Carcinoma1 | ||||||||
| AURKA EXPRESSION | (prognostic) | Prognostic | B | Supports Better Outcome | 3 | accepted | EID416In patients with ovarian carcinomas, those with Aurora kinase A expression (as measured by immunohistochemistry) had increased progression-free and overall survival compared to those without expressio… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available