Publication
P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (9)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 9
- cancerLung Adenocarcinomacivic_curation1.00
- drugAlectinibcivic_curation1.00
- drugCeritinibcivic_curation1.00
- drugCrizotinibcivic_curation1.00
- drugLorlatinibcivic_curation1.00
- geneABCB1civic_curation1.00
- geneALKcivic_curation1.00
- variantABCB1 Overexpressioncivic_curation1.00
- variantALK Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26870817
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ABCB1 Overexpression + ALK FusionALKABCB12 | ||||||||
| Alectinib + LorlatinibSubstitutes | Lung Adenocarcinoma | Predictive | D | Does Not Support Resistance | 3 | accepted | EID10016EML4-ALK fusion positive lung adenocarcinoma cell lines with high expression of P-gp (ABCB1 gene) (H3122 and the newly established JFCR013-2) were found to be resistant to crizotinib and ceritinib. P-… (full text at CIViC) PMID 26870817 · Katayama et al., 2016 · Open in CIViC | civic |
| Ceritinib + CrizotinibSubstitutes | Lung Adenocarcinoma | Predictive | D | Supports Resistance | 3 | accepted | EID7869EML4-ALK fusion positive lung adenocarcinoma cell lines (H3122 and the newly established JFCR013-2) with high expression of P-gp (ABCB1 gene) were found to be resistant to crizotinib and ceritinib. P… (full text at CIViC) PMID 26870817 · Katayama et al., 2016 · Open in CIViC | civic |