Soft Tissue Neoplasm — Genomics

Soft Tissue Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

6 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Gastrointestinal Stromal Tumor (MSK 2025) gist_msk_2025

183 cases with simple somatic mutation data · 183 cases total · 2026-01-20 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KIT	Ssm	174	183

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Gastrointestinal Stromal Tumor (MSK, NPJ Precis Oncol 2023) gist_msk_2022MSK

499 cases with simple somatic mutation data · 499 cases total · 2026-01-07 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KIT	Ssm	384	499	77%	cbioportal
2	PDGFRA	Ssm	49	499	9.8%	cbioportal
3	TP53	Ssm	21	499	4.2%	cbioportal
5	SETD2	Ssm	20	499	4%	cbioportal
4	NF1	Ssm	20	499	4%	cbioportal
6	MGA	Ssm	18	479	3.8%	cbioportal
7	MAX	Ssm	17	499	3.4%	cbioportal
10	CSDE1	Ssm	12	374	3.2%	cbioportal
8	RB1	Ssm	15	499	3%	cbioportal
11	KMT2B	Ssm	10	374	2.7%	cbioportal
9	PTEN	Ssm	13	499	2.6%	cbioportal
12	SDHA	Ssm	10	499	2%	cbioportal
13	TSC1	Ssm	10	499	2%	cbioportal
14	PIK3CA	Ssm	9	499	1.8%	cbioportal
186	REST	Ssm	1	66	1.5%	cbioportal
123	CYP19A1	Ssm	1	66	1.5%	cbioportal
100	ALB	Ssm	1	66	1.5%	cbioportal
16	ATM	Ssm	7	499	1.4%	cbioportal
15	ARID1A	Ssm	7	499	1.4%	cbioportal
19	MTOR	Ssm	6	499	1.2%	cbioportal
18	KMT2C	Ssm	6	499	1.2%	cbioportal
17	CBL	Ssm	6	499	1.2%	cbioportal
21	ROS1	Ssm	5	499	1%	cbioportal
20	CREBBP	Ssm	5	499	1%	cbioportal
22	ANKRD11	Ssm	4	479	0.8%	cbioportal
28	TGFBR2	Ssm	4	499	0.8%	cbioportal
27	JAK1	Ssm	4	499	0.8%	cbioportal
24	DNMT3A	Ssm	4	499	0.8%	cbioportal
25	GRIN2A	Ssm	4	499	0.8%	cbioportal
26	IRS2	Ssm	4	499	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gastrointestinal Stromal Tumors (MSK, Clin Cancer Res 2023) gist_msk_2023MSK

469 cases with simple somatic mutation data · 469 cases total · 2026-01-07 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KIT	Ssm	353	469	75.3%	cbioportal
2	PDGFRA	Ssm	52	469	11.1%	cbioportal
4	TP53	Ssm	21	469	4.5%	cbioportal
3	NF1	Ssm	21	469	4.5%	cbioportal
5	SETD2	Ssm	19	469	4.1%	cbioportal
7	MGA	Ssm	18	447	4%	cbioportal
6	MAX	Ssm	18	469	3.8%	cbioportal
8	RB1	Ssm	17	469	3.6%	cbioportal
49	APLNR	Ssm	2	61	3.3%	cbioportal
9	CSDE1	Ssm	11	342	3.2%	cbioportal
10	PTEN	Ssm	10	469	2.1%	cbioportal
12	SDHA	Ssm	9	469	1.9%	cbioportal
11	PIK3CA	Ssm	9	469	1.9%	cbioportal
13	ARID1A	Ssm	8	469	1.7%	cbioportal
14	TSC1	Ssm	8	469	1.7%	cbioportal
138	KBTBD4	Ssm	1	61	1.6%	cbioportal
113	CYP19A1	Ssm	1	61	1.6%	cbioportal
175	REST	Ssm	1	61	1.6%	cbioportal
15	CREBBP	Ssm	7	469	1.5%	cbioportal
16	KMT2D	Ssm	7	469	1.5%	cbioportal
17	MTOR	Ssm	6	469	1.3%	cbioportal
18	ROS1	Ssm	6	469	1.3%	cbioportal
23	ZFHX3	Ssm	5	447	1.1%	cbioportal
19	ATM	Ssm	5	469	1.1%	cbioportal
21	KMT2A	Ssm	5	469	1.1%	cbioportal
20	CBL	Ssm	5	469	1.1%	cbioportal
22	KMT2C	Ssm	5	469	1.1%	cbioportal
38	KMT2B	Ssm	3	342	0.9%	cbioportal
29	PIK3C2G	Ssm	4	469	0.9%	cbioportal
27	IRS2	Ssm	4	469	0.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Myoepithelial Carcinomas of Soft Tissue (WCM, CSH Molecular Case Studies 2022) stmyec_wcm_2022WCM

12 cases with simple somatic mutation data · 12 cases total · 2026-01-13 · mapped to Malignant Myoepithelioma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CORO2A	Ssm	6	12	50%	cbioportal
2	COL4A2	Ssm	5	12	41.7%	cbioportal
3	KCNJ10	Ssm	5	12	41.7%	cbioportal
4	OXA1L	Ssm	5	12	41.7%	cbioportal
5	SPECC1	Ssm	5	12	41.7%	cbioportal
6	STON1	Ssm	5	12	41.7%	cbioportal
7	SYT7	Ssm	5	12	41.7%	cbioportal
8	CDCP1	Ssm	4	12	33.3%	cbioportal
9	DCHS1	Ssm	4	12	33.3%	cbioportal
10	EPPK1	Ssm	4	12	33.3%	cbioportal
11	FRAS1	Ssm	4	12	33.3%	cbioportal
12	ITGB4	Ssm	4	12	33.3%	cbioportal
13	NUP50	Ssm	4	12	33.3%	cbioportal
14	RBM14-RBM4	Ssm	4	12	33.3%	cbioportal
15	POLE	Ssm	3	12	25%	cbioportal
16	PTGFR	Ssm	3	12	25%	cbioportal
17	SCNN1G	Ssm	3	12	25%	cbioportal
18	CELF4	Ssm	2	12	16.7%	cbioportal
19	LRP10	Ssm	2	12	16.7%	cbioportal
20	PRSS1	Ssm	2	12	16.7%	cbioportal
21	PTPN21	Ssm	2	12	16.7%	cbioportal
22	TGFBR1	Ssm	2	12	16.7%	cbioportal
23	TMEM121	Ssm	2	12	16.7%	cbioportal
57	LINGO3	Ssm	1	12	8.3%	cbioportal
24	AMPD3	Ssm	1	12	8.3%	cbioportal
25	ARHGEF2	Ssm	1	12	8.3%	cbioportal
26	ARHGEF40	Ssm	1	12	8.3%	cbioportal
27	ARIH2	Ssm	1	12	8.3%	cbioportal
28	ASMTL	Ssm	1	12	8.3%	cbioportal
29	BRAF	Ssm	1	12	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Sarcoma/Mesenchymal (MSK, Clin Cancer Res 2020) usarc_msk_2020MSK

108 cases with simple somatic mutation data · 108 cases total · 2026-01-19 · mapped to Uterine Corpus Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	108	37%	cbioportal
2	ATRX	Ssm	25	108	23.1%	cbioportal
3	RB1	Ssm	12	108	11.1%	cbioportal
4	MED12	Ssm	11	108	10.2%	cbioportal
5	BRCA2	Ssm	7	108	6.5%	cbioportal
7	PTEN	Ssm	6	108	5.6%	cbioportal
6	FAT1	Ssm	6	108	5.6%	cbioportal
57	AGO2	Ssm	1	20	5%	cbioportal
145	TEK	Ssm	1	20	5%	cbioportal
130	PPARG	Ssm	1	20	5%	cbioportal
8	AR	Ssm	5	108	4.6%	cbioportal
9	ROS1	Ssm	5	108	4.6%	cbioportal
10	ARID2	Ssm	4	108	3.7%	cbioportal
11	KDR	Ssm	4	108	3.7%	cbioportal
12	NSD1	Ssm	4	108	3.7%	cbioportal
13	PDGFRB	Ssm	4	108	3.7%	cbioportal
14	PIK3CA	Ssm	4	108	3.7%	cbioportal
17	BRD4	Ssm	3	108	2.8%	cbioportal
15	ARID1A	Ssm	3	108	2.8%	cbioportal
16	ASXL1	Ssm	3	108	2.8%	cbioportal
18	CARD11	Ssm	3	108	2.8%	cbioportal
19	DAXX	Ssm	3	108	2.8%	cbioportal
20	ERBB4	Ssm	3	108	2.8%	cbioportal
21	KMT2A	Ssm	3	108	2.8%	cbioportal
22	MET	Ssm	3	108	2.8%	cbioportal
23	NF1	Ssm	3	108	2.8%	cbioportal
24	TERT	Ssm	3	108	2.8%	cbioportal
55	TOP1	Ssm	2	108	1.9%	cbioportal
49	PIK3CG	Ssm	2	108	1.9%	cbioportal
50	POLE	Ssm	2	108	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-19