Serous Adenocarcinoma — Genomics

Serous Adenocarcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

8 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

High-Grade Serous Ovarian Cancer (MSK, NPJ Genome Med 2021) hgsoc_msk_2021MSK

45 cases with simple somatic mutation data · 45 cases total · 2026-01-07 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

High-Grade Serous Ovarian Cancer (TCGA GDC, 2025) hgsoc_tcga_gdcTCGA GDC

405 cases with simple somatic mutation data · 604 cases total · 2026-01-13 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	369	405	91.1%	cbioportal
2	TTN	Ssm	96	405	23.7%	cbioportal
3	CSMD3	Ssm	36	405	8.9%	cbioportal
4	USH2A	Ssm	31	405	7.7%	cbioportal
5	NF1	Ssm	29	405	7.2%	cbioportal
6	RYR2	Ssm	28	405	6.9%	cbioportal
8	MUC16	Ssm	26	405	6.4%	cbioportal
7	HMCN1	Ssm	26	405	6.4%	cbioportal
9	FAT3	Ssm	23	405	5.7%	cbioportal
11	SI	Ssm	22	405	5.4%	cbioportal
10	MACF1	Ssm	22	405	5.4%	cbioportal
15	MUC17	Ssm	21	405	5.2%	cbioportal
14	FLG2	Ssm	21	405	5.2%	cbioportal
13	APOB	Ssm	21	405	5.2%	cbioportal
12	AHNAK	Ssm	21	405	5.2%	cbioportal
19	LRP1B	Ssm	20	405	4.9%	cbioportal
16	CDK12	Ssm	20	405	4.9%	cbioportal
17	DNAH3	Ssm	20	405	4.9%	cbioportal
18	FLG	Ssm	20	405	4.9%	cbioportal
22	DST	Ssm	19	405	4.7%	cbioportal
21	DNAH5	Ssm	19	405	4.7%	cbioportal
23	LRP1	Ssm	19	405	4.7%	cbioportal
20	BRCA1	Ssm	19	405	4.7%	cbioportal
24	COL6A3	Ssm	18	405	4.4%	cbioportal
28	TG	Ssm	18	405	4.4%	cbioportal
27	SYNE2	Ssm	18	405	4.4%	cbioportal
26	SYNE1	Ssm	18	405	4.4%	cbioportal
25	FCGBP	Ssm	18	405	4.4%	cbioportal
30	DNAH8	Ssm	17	405	4.2%	cbioportal
29	DNAH10	Ssm	17	405	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Low-Grade Serous Ovarian Cancer (MSK, Clin Cancer Res 2022) lgsoc_mapk_msk_2022MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Low-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	38	119	31.9%	cbioportal
2	NRAS	Ssm	13	119	10.9%	cbioportal
3	BRAF	Ssm	11	119	9.2%	cbioportal
4	EIF1AX	Ssm	11	119	9.2%	cbioportal
5	KMT2D	Ssm	5	119	4.2%	cbioportal
6	ERBB2	Ssm	4	119	3.4%	cbioportal
7	ANKRD11	Ssm	3	111	2.7%	cbioportal
8	ARID1B	Ssm	3	119	2.5%	cbioportal
15	MET	Ssm	2	119	1.7%	cbioportal
12	KMT2A	Ssm	2	119	1.7%	cbioportal
9	ATRX	Ssm	2	119	1.7%	cbioportal
10	BARD1	Ssm	2	119	1.7%	cbioportal
11	CTCF	Ssm	2	119	1.7%	cbioportal
13	KMT2C	Ssm	2	119	1.7%	cbioportal
14	MAP3K1	Ssm	2	119	1.7%	cbioportal
16	NF1	Ssm	2	119	1.7%	cbioportal
17	NF2	Ssm	2	119	1.7%	cbioportal
18	PTPRS	Ssm	2	119	1.7%	cbioportal
19	RB1	Ssm	2	119	1.7%	cbioportal
20	ROS1	Ssm	2	119	1.7%	cbioportal
21	RUNX1	Ssm	2	119	1.7%	cbioportal
22	TBX3	Ssm	2	119	1.7%	cbioportal
23	TERT	Ssm	2	119	1.7%	cbioportal
24	TP53	Ssm	2	119	1.7%	cbioportal
88	RTEL1	Ssm	1	88	1.1%	cbioportal
36	CARM1	Ssm	1	88	1.1%	cbioportal
71	MSH3	Ssm	1	88	1.1%	cbioportal
52	ERF	Ssm	1	88	1.1%	cbioportal
48	EPAS1	Ssm	1	88	1.1%	cbioportal
83	PPP6C	Ssm	1	111	0.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Ovarian Serous Cystadenocarcinoma TCGA-OVTCGA

603 cases with simple somatic mutation data · 608 cases total · Data Release 46.0 · mapped to Ovarian Serous Cystadenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	483	603	80.1%	gdc
2	MYC	Ssm	455	603	75.5%	gdc
3	POU5F1B	Ssm	449	603	74.5%	gdc
4	FAM135B	Ssm	449	603	74.5%	gdc
5	ACTRT3	Ssm	447	603	74.1%	gdc
6	AGO2	Ssm	446	603	74%	gdc
9	PTK2	Ssm	446	603	74%	gdc
7	ADCY8	Ssm	446	603	74%	gdc
8	MYNN	Ssm	446	603	74%	gdc
10	LRRC34	Ssm	446	603	74%	gdc
15	LRRIQ4	Ssm	445	603	73.8%	gdc
13	LRRC31	Ssm	445	603	73.8%	gdc
14	GPR20	Ssm	445	603	73.8%	gdc
11	GSDMC	Ssm	445	603	73.8%	gdc
16	LRATD2	Ssm	445	603	73.8%	gdc
12	PTP4A3	Ssm	445	603	73.8%	gdc
19	AC138647.1	Ssm	444	603	73.6%	gdc
17	SAMD7	Ssm	444	603	73.6%	gdc
21	ASAP1	Ssm	444	603	73.6%	gdc
24	TG	Ssm	444	603	73.6%	gdc
23	CHRAC1	Ssm	444	603	73.6%	gdc
22	SEC62	Ssm	444	603	73.6%	gdc
18	SLC45A4	Ssm	444	603	73.6%	gdc
20	TRIB1	Ssm	444	603	73.6%	gdc
27	KHDRBS3	Ssm	443	603	73.5%	gdc
28	KCNK9	Ssm	443	603	73.5%	gdc
29	MECOM	Ssm	443	603	73.5%	gdc
25	GPR160	Ssm	443	603	73.5%	gdc
30	SCRIB	Ssm	443	603	73.5%	gdc
33	CYRIB	Ssm	443	603	73.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Ovarian Serous Cystadenocarcinoma (TCGA, Firehose Legacy) ov_tcgaTCGA

316 cases with simple somatic mutation data · 617 cases total · 2026-01-12 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	277	316	87.7%	cbioportal
2	TTN	Ssm	56	316	17.7%	cbioportal
3	USH2A	Ssm	20	316	6.3%	cbioportal
4	FAT3	Ssm	19	316	6%	cbioportal
5	CSMD3	Ssm	18	316	5.7%	cbioportal
6	MUC16	Ssm	18	316	5.7%	cbioportal
7	HMCN1	Ssm	15	316	4.7%	cbioportal
8	LRP2	Ssm	15	316	4.7%	cbioportal
10	RYR2	Ssm	14	316	4.4%	cbioportal
9	NF1	Ssm	14	316	4.4%	cbioportal
11	DNAH5	Ssm	13	316	4.1%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
14	AHNAK2	Ssm	12	316	3.8%	cbioportal
15	BRCA1	Ssm	12	316	3.8%	cbioportal
16	COL6A3	Ssm	12	316	3.8%	cbioportal
17	APOB	Ssm	11	316	3.5%	cbioportal
18	BRCA2	Ssm	11	316	3.5%	cbioportal
19	DNAH3	Ssm	11	316	3.5%	cbioportal
20	FAT1	Ssm	11	316	3.5%	cbioportal
21	HUWE1	Ssm	11	316	3.5%	cbioportal
22	HYDIN	Ssm	11	316	3.5%	cbioportal
23	MUC17	Ssm	11	316	3.5%	cbioportal
24	RYR1	Ssm	11	316	3.5%	cbioportal
26	PKHD1	Ssm	10	316	3.2%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
27	SI	Ssm	10	316	3.2%	cbioportal
28	TENM1	Ssm	10	316	3.2%	cbioportal
29	CDK12	Ssm	9	316	2.8%	cbioportal
30	COL22A1	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011) ov_tcga_pubTCGA

316 cases with simple somatic mutation data · 489 cases total · 2026-01-21 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	303	316	95.9%	cbioportal
2	TTN	Ssm	55	316	17.4%	cbioportal
3	BRCA1	Ssm	37	316	11.7%	cbioportal
4	BRCA2	Ssm	34	316	10.8%	cbioportal
5	USH2A	Ssm	20	316	6.3%	cbioportal
6	CSMD3	Ssm	19	316	6%	cbioportal
8	MUC16	Ssm	18	316	5.7%	cbioportal
7	FAT3	Ssm	18	316	5.7%	cbioportal
9	LRP2	Ssm	15	316	4.7%	cbioportal
11	RYR2	Ssm	14	316	4.4%	cbioportal
10	HMCN1	Ssm	14	316	4.4%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
16	NF1	Ssm	12	316	3.8%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
14	DNAH3	Ssm	12	316	3.8%	cbioportal
15	DNAH5	Ssm	12	316	3.8%	cbioportal
18	APOB	Ssm	11	316	3.5%	cbioportal
17	AHNAK2	Ssm	11	316	3.5%	cbioportal
22	TENM1	Ssm	11	316	3.5%	cbioportal
21	MUC17	Ssm	11	316	3.5%	cbioportal
20	HYDIN	Ssm	11	316	3.5%	cbioportal
19	FAT1	Ssm	11	316	3.5%	cbioportal
26	RYR1	Ssm	10	316	3.2%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
24	HUWE1	Ssm	10	316	3.2%	cbioportal
23	COL6A3	Ssm	10	316	3.2%	cbioportal
28	CDK12	Ssm	9	316	2.8%	cbioportal
27	ADGRB3	Ssm	9	316	2.8%	cbioportal
30	DST	Ssm	9	316	2.8%	cbioportal
29	COL22A1	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-21

Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) ov_tcga_pan_can_atlas_2018TCGA

523 cases with simple somatic mutation data · 585 cases total · 2026-06-04 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	373	523	71.3%	cbioportal
2	TTN	Ssm	110	523	21%	cbioportal
3	FLG2	Ssm	41	523	7.8%	cbioportal
4	MUC16	Ssm	41	523	7.8%	cbioportal
5	CSMD3	Ssm	38	523	7.3%	cbioportal
6	HMCN1	Ssm	34	523	6.5%	cbioportal
7	USH2A	Ssm	32	523	6.1%	cbioportal
8	AHNAK2	Ssm	30	523	5.7%	cbioportal
9	FLG	Ssm	30	523	5.7%	cbioportal
10	NF1	Ssm	30	523	5.7%	cbioportal
11	MACF1	Ssm	29	523	5.5%	cbioportal
12	RYR2	Ssm	28	523	5.4%	cbioportal
13	AHNAK	Ssm	26	523	5%	cbioportal
14	SYNE1	Ssm	26	523	5%	cbioportal
16	DNAH3	Ssm	24	523	4.6%	cbioportal
17	FAT3	Ssm	24	523	4.6%	cbioportal
20	MUC17	Ssm	24	523	4.6%	cbioportal
19	LRP2	Ssm	24	523	4.6%	cbioportal
18	KMT2C	Ssm	24	523	4.6%	cbioportal
15	APOB	Ssm	24	523	4.6%	cbioportal
21	RYR1	Ssm	23	523	4.4%	cbioportal
23	DST	Ssm	22	523	4.2%	cbioportal
22	COL6A3	Ssm	22	523	4.2%	cbioportal
24	MDN1	Ssm	22	523	4.2%	cbioportal
25	SI	Ssm	22	523	4.2%	cbioportal
29	MYH1	Ssm	21	523	4%	cbioportal
28	LRP1B	Ssm	21	523	4%	cbioportal
27	FCGBP	Ssm	21	523	4%	cbioportal
26	DNAH5	Ssm	21	523	4%	cbioportal
30	FAT4	Ssm	20	523	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-04