Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level386 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,549 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT05513742 | A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer(COMPANION-003) | completed | Phase 2 | 49 | Compass TherapeuticsINDUSTRY | 1 | Sep 25, 2026 | clinicaltrials |
| NCT02997553 | Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery(GASVERT) | completed | Phase 3 | 744 | Institut de Cancérologie de LorraineOTHER | 1 | Sep 1, 2026 |
| clinicaltrials |
| NCT00712751 | The Sexual Health of Rectal Cancer Patients | completed | — | 149 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Aug 26, 2026 | clinicaltrials |
| NCT04942626 | Capecitabine-based Chemoradiotherapy in Combination With the IL-1 Receptor Antagonist Anakinra for Rectal Cancer Patients(ACO/ARO/AIO-21) | completed | Phase 1 | 12 | Goethe UniversityOTHER | 1 | Aug 17, 2026 | clinicaltrials |
| NCT04104139 | TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer | completed | Phase 1 | 19 | OHSU Knight Cancer InstituteOTHER | 1 | Aug 6, 2026 | clinicaltrials |
| NCT06908031 | SCRT+mFOLFOX6+PD-1 Antibody and Targeted Therapy for High-Risk pMMR/MSS Rectal Cancer(CRIT) | completed | Phase 2 | 49 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 1 | Aug 4, 2026 | clinicaltrials |
| NCT07736131 | Learning Curve of SILS in CRC(SILS) | completed | — | 280 | Ruijin HospitalOTHER | 0 | Jul 30, 2026 | clinicaltrials |
| NCT05538195 | Safety and Efficacy of CEA-targeted CAR-T for CEA-positive Advanced Malignant Solid Tumors | completed | Phase 1 / Phase 2 | 17 | Chongqing Precision Biotech Co., LtdINDUSTRY | 1 | Jul 10, 2026 | clinicaltrials |
| NCT03879109 | Chemotherapy Followed by Pelvic Reirradiation Versus Chemotherapy Alone as Pre-operative Treatment for Locally Recurrent Rectal Cancer(GRECCAR15) | completed | Phase 3 | 58 | University Hospital, BordeauxOTHER | 1 | Jul 8, 2026 | clinicaltrials |
| NCT03345563 | Project HERO: Health Empowerment & Recovery Outcomes(HERO) | completed | N/A | 113 | Rutgers, The State University of New JerseyOTHER | 1 | Jul 7, 2026 | clinicaltrials |
| NCT06884670 | Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study | completed | Phase 2 | 130 | The First Affiliated Hospital with Nanjing Medical UniversityOTHER | 1 | Jun 24, 2026 | clinicaltrials |
| NCT04323722 | Impact of Bladder Depletion on Mesorectal Movements During Radiotherapy in Rectal Cancer(MESORECT-VV) | completed | N/A | 53 | Institut Cancerologie de l'OuestOTHER | 1 | Jun 23, 2026 | clinicaltrials |
| NCT07619768 | Self Regulation Hypnotic Intervention for Pain and Anxiety During Rectal Brachytherapy | completed | N/A | 52 | Sir Mortimer B. Davis - Jewish General HospitalOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT02514278 | Optimisation of Response for Organ Preservation in Rectal Cancer : Neoadjuvant Chemotherapy and Radiochemotherapy vs. Radiochemotherapy(GRECCAR12) | completed | Phase 3 | 218 | University Hospital, BordeauxOTHER | 1 | May 14, 2026 | clinicaltrials |
| NCT04864067 | No Operation After Short Course Radiotherapy Followed By Consolidation Chemotherapy In Locally Advanced Rectal Cancer(NOAHS-ARC) | completed | Phase 2 | 39 | Servicio de Salud Metropolitano Sur OrienteOTHER_GOV | 1 | May 8, 2026 | clinicaltrials |
| NCT06189846 | Lumeneye Rectoscope for Assessment on Tumor Response After Total Neoadjuvant Treatment in Rectal Cancer(LUMEVAL) | completed | — | 82 | Bordeaux Colorectal Institute AcademyOTHER | 5 | May 7, 2026 | clinicaltrials |
| NCT04130854 | INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer | completed | Phase 2 | 58 | University of Texas Southwestern Medical CenterOTHER | 1 | May 6, 2026 | clinicaltrials |
| NCT06212128 | RAPIDO vs LCRT vs Upfront Surgery - a Prospective Cohort Study(RAPIDO) | completed | — | 57 | Sengkang General HospitalOTHER | 0 | Apr 30, 2026 | clinicaltrials |
| NCT02584985 | Evaluate Efficacy, Morbidity and Functional Outcome of Endoscopic TranAnal Proctectomy vs Standard Transabdominal Laparoscopic Proctectomy for Rectal Cancer(ETAP) | completed | Phase 3 | 226 | Institut Paoli-CalmettesOTHER | 1 | Apr 21, 2026 | clinicaltrials |
| NCT03259035 | NEO: Neoadjuvant Chemotherapy, Excision and Observation for Early Rectal Cancer | completed | Phase 2 | 58 | Canadian Cancer Trials GroupNETWORK | 2 | Apr 9, 2026 | clinicaltrials |
| NCT05515796 | Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors | completed | Phase 2 | 189 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityOTHER | 1 | Apr 1, 2026 | clinicaltrials |
| NCT02437656 | Combination of Metformin to Neoadjuvant Radiochemotherapy in the Treatment of Locally Advanced Rectal Cancer.(METCAP) | completed | Phase 2 | 60 | Centre Oscar LambretOTHER | 1 | Mar 31, 2026 | clinicaltrials |
| NCT06698289 | Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients | completed | — | 70 | Mersin UniversityOTHER | 1 | Mar 25, 2026 | clinicaltrials |
| NCT06006260 | Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer. | completed | — | 107 | Chang Gung Memorial HospitalOTHER | 1 | Mar 20, 2026 | clinicaltrials |
| NCT03292289 | Assessment of Symptoms and Consequences of Coloanal Continuity Reconstruction(QUALIPRO) | completed | N/A | 65 | Centre Oscar LambretOTHER | 1 | Mar 17, 2026 | clinicaltrials |
| NCT06608537 | A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant Chemoradiotherapy for MSS Rectal Cancer | completed | Phase 2 | 52 | Sun Yat-sen UniversityOTHER | 1 | Mar 4, 2026 | clinicaltrials |
| NCT02738359 | Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening(FAMCAP) | completed | — | 84 | Hôpital Edouard HerriotOTHER | 1 | Feb 27, 2026 | clinicaltrials |
| NCT07428239 | Pilot Study of Individualized Comprehensive Rehabilitation in Patients With Colorectal Cancer | completed | N/A | 150 | Institute of Oncology LjubljanaOTHER | 1 | Feb 23, 2026 | clinicaltrials |
| NCT07398716 | Intraoperative Assessment of Distal Resection Margins Using Frozen Section in Mid and Low Rectal Cancer Surgery | completed | N/A | 99 | Bakirkoy Dr. Sadi Konuk Research and Training HospitalOTHER_GOV | 1 | Feb 11, 2026 | clinicaltrials |
| NCT03365882 | S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery | completed | Phase 2 | 240 | SWOG Cancer Research NetworkNETWORK | 2 | Feb 10, 2026 | clinicaltrials |
| NCT04109924 | TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study | completed | Phase 2 | 42 | Roswell Park Cancer InstituteOTHER | 1 | Feb 10, 2026 | clinicaltrials |
| NCT06241703 | Effect of ICCAUT Strategy on Postoperative Urinary Dysfunction After Radical Rectal Cancer Surgery(ICCAUT-1) | completed | N/A | 400 | The First Hospital of Jilin UniversityOTHER | 1 | Jan 30, 2026 | clinicaltrials |
| NCT02591407 | Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery(TAP) | completed | N/A | 200 | Trinity Health MichiganOTHER | 1 | Jan 28, 2026 | clinicaltrials |
| NCT04362839 | Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer | completed | Phase 1 | 39 | City of Hope Medical CenterOTHER | 1 | Jan 28, 2026 | clinicaltrials |
| NCT05746195 | Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) | completed | N/A | 46 | University of California, San FranciscoOTHER | 1 | Jan 22, 2026 | clinicaltrials |
| NCT04505553 | Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer | completed | Phase 2 | 78 | University of WashingtonOTHER | 1 | Jan 21, 2026 | clinicaltrials |
| NCT06426927 | PeLear CCC: Proyecto Latino Contra Cancer Colorrectal(PeLear CCC) | completed | N/A | 60 | University of North Carolina, Chapel HillOTHER | 1 | Jan 21, 2026 | clinicaltrials |
| NCT00826540 | Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer | completed | Phase 2 | 83 | Alliance for Clinical Trials in OncologyOTHER | 1 | Jan 20, 2026 | clinicaltrials |
| NCT07351708 | Development and Validation of a Post-operative Risk Of Local Recurrence Model Integrating Serology and Evalution (PROMISE) in Local Advanced Rectal Cancer Receiving Neoadjuvant Therapy: a Multicenter Study(PROMISE model) | completed | — | 2,315 | Cai ZerongOTHER | 0 | Jan 20, 2026 | clinicaltrials |
| NCT07346729 | Exploring the Predictive Effect of Intestinal and Oral Microbiota on the Efficacy of Neoadjuvant Radiotherapy and Chemotherapy for Locally Advanced Rectal Cancer Based on Machine Learning | completed | — | 60 | Nanfang Hospital, Southern Medical UniversityOTHER | 1 | Jan 16, 2026 | clinicaltrials |
| NCT05876026 | MRI T1 Relaxation Time in Rectal Cancer | completed | — | 44 | Vejle HospitalOTHER | 1 | Jan 7, 2026 | clinicaltrials |
| NCT05215379 | Neoadjuvant Chemoradiation Therapy Combined With Immunotherapy for MSS Ultra-low Rectal Cancer | completed | Phase 2 / Phase 3 | 201 | Changhai HospitalOTHER | 1 | Jan 2, 2026 | clinicaltrials |
| NCT04369053 | Prevention of Colorectal Cancer Through Multiomics Blood Testing(PREEMPT CRC) | completed | — | 48,995 | Freenome Holdings Inc.INDUSTRY | 2 | Dec 26, 2025 | clinicaltrials |
| NCT02314182 | GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis(GRECCAR8) | completed | Phase 3 | 5 | Hospices Civils de LyonOTHER | 1 | Dec 19, 2025 | clinicaltrials |
| NCT02965521 | Survivor Choices for Eating and Drinking - Colorectal Cancer(SUCCEED) | completed | N/A | 50 | University of California, San FranciscoOTHER | 1 | Dec 17, 2025 | clinicaltrials |
| NCT04417699 | SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer(SHORT) | completed | Phase 2 | 13 | Providence Health & ServicesOTHER | 1 | Dec 10, 2025 | clinicaltrials |
| NCT02921256 | Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer | completed | Phase 2 | 363 | National Cancer Institute (NCI)NIH | 2 | Dec 4, 2025 | clinicaltrials |
| NCT03628248 | Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery(AMIREMBOL) | completed | N/A | 10 | Centre Hospitalier Universitaire de NīmesOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT06493240 | Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer(NLCCRIT-LARC) | completed | Phase 2 | 30 | Peking University People's HospitalOTHER | 1 | Nov 25, 2025 | clinicaltrials |
Data updated 4 days agoSource updated Sep 25, 2026source: clinicaltrials