Clinical trial · Observational
RAPIDO vs LCRT vs Upfront Surgery - a Prospective Cohort Study
Novel Objective Comparison of Short-term Surgical Outcomes From Total Mesorectal Excision Between Total Neoadjuvant Therapy - Rapido Protocol, Standard Long Course Radiotherapy and Upfront Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Aim: We evaluated the surgical outcomes of 3 groups of patients with rectal cancers - RAPIDO vs standard long course radiotherapy (LCRT) vs upfront surgery to objectively determine the effects of TNT on TME. Methods: A review of prospectively collected data was performed for patients who have rectal cancer and underwent low anterior resection from January 2016 to May 2022. Data on patient demographics, disease staging, peri-operative details and up to 2-year follow-up outcomes were analysed. The surgical and oncological outcomes were compared. Patients were followed up until 31 May 2022.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| LCRT | Combination Product | — | UNRESOLVED |
| RAPIDO TNT | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- RAPIDO TNT
- description
- neoadjuvant therapy per RAPIDO protocol
- interventionNames
- Combination Product: RAPIDO TNT
- label
- LCRT
- description
- long course chemoradiotherapy
- interventionNames
- Combination Product: LCRT
- label
- upfront surgery
- description
- directly went for surgery after diagnosis of rectal cancer
Primary outcomes (1)
- measure
- operative time required for primary resection of rectal tumour
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * diagnosed with rectal cancer * due to undergo ultra-low anterior resection (ULAR) Exclusion Criteria: * emergency surgery * unresectable metastatic disease at presentation
References
Publications (0)
Data not yet available