Clinical trial · Observational
Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients
Prevalence of Preoperative Sarcopenia and Its Impact on Surgical Outcomes in Patients With Colorectal Cancer: A Prospective Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. Muscle mass loss in oncology patients is most often the result of cancer-related malnutrition. Sarcopenia is a progressive and generalized skeletal muscle disorder associated with increased likelihood of adverse outcomes such as physical disability, poor quality of life, and death. It is characterized by low muscle strength, low muscle quantity and quality, and low physical performance. Sarcopenia is highly prevalent in older adults and those with chronic diseases, including cancer. In the context of colorectal cancer, preoperative sarcopenia has been linked to increased postoperative complications, longer hospital stays, and reduced survival. The aim of this prospective observational study is to evaluate the prevalence of preoperative sarcopenia and postoperative outcomes in patients with colorectal cancer, using validated methods to assess muscle strength, muscle mass, and physical performance.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
| Sarcopenia | — | UNRESOLVED | — |
| Surgical Outcomes | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Sarcopenia
- description
- Patients who meet the diagnostic criteria for sarcopenia will be included in this group. The diagnosis of sarcopenia will be made using the criteria defined by the European Working Group on Sarcopenia in Older People (EWGSOP). This requires the presence of both low muscle strength (e.g. low handgrip strength) and low muscle quantity/quality (e.g. low skeletal muscle index on CT scan). Patients will further classified into stages of "probable sarcopenia", "sarcopenia", and "severe sarcopenia" based on the severity.
- label
- Non-sarcopenia
- description
- Patients who do not meet the diagnostic criteria for sarcopenia will be included in this group. They will have normal or above-normal muscle strength and muscle quantity/quality measurements. This group will serve as the comparison cohort to evaluate the impact of sarcopenia on surgical outcomes.
Primary outcomes (1)
- measure
- Postoperative Complications
- timeFrame
- 30 days post-surgery
- description
- Postoperative complications will be systematically evaluated and graded according to the Clavien-Dindo Classification system over a 30-day follow-up period. All complications will be documented daily during hospitalization and at scheduled follow-up visits, with particular attention to surgical site infections, anastomotic leakage, pulmonary complications, and prolonged ileus. This comprehensive assessment will enable detailed analysis of the relationship between preoperative sarcopenia and postoperative outcomes, potentially identifying high-risk patients who might benefit from preoperative optimization strategies.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Having a diagnosis of colon cancer * Having undergone surgery at Mersin University General Surgery Department as of 15.11.2024 * Patients aged 18 years and above * Patients whose descriptive and clinical characteristics are recorded in their medical files * Those who have signed the Informed Volunteer Consent Form/Written Consent Form Exclusion Criteria: * Patients under 18 years of age * Patients whose descriptive and clinical characteristics are not recorded in the file records * Those who did not sign the Informed Volunteer Form/Written Consent Form
References
Publications (1)
- DERIVEDYilmaz M, Barcin M, Tuna S, Koc HB, Bozkurt ME, Aslan G, Ozcan C, Bozkurt H, Colak T. Prevalence of preoperative sarcopenia according to EWGSOP2 in patients with colorectal cancer and its impact on surgical outcomes: a prospective observational study. BMC Surg. 2026 Jun 11. doi: 10.1186/s12893-026-03935-8. Online ahead of print. PMID 42277777