Clinical trial · Interventional
Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery
Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery - A Single-center Feasibility Pilot Study.
NCT03628248CI-TRIAL-00098441AMIREMBOLcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators hypothesize that a primary embolization, 3-4 weeks before surgery, would allow development of vascular collaterality, in particular for the marginal artery which will ensure a better colonic perfusion.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Rectum | Rectal Carcinoma | ALIAS | 0.90 |
| Cancer, Sigmoid | Malignant Neoplasm | ALIAS | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| embolization of the inferior mesenteric artery | Procedure | — | UNRESOLVED |
| Inferior mesenteric artery ligation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- embolization
- interventionNames
- Procedure: embolization of the inferior mesenteric artery
- Procedure: Inferior mesenteric artery ligation
- type
- OTHER
- label
- No embolization
- interventionNames
- Procedure: Inferior mesenteric artery ligation
Primary outcomes (9)
- measure
- Oxygen saturation of the colon after inferior mesenteric artery ligation between groups
- timeFrame
- Prior to start of surgery
- description
- Digital oxymeter (%)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient is at least 18 years old and less than 80 years old * Patient has rectal cancer or sigmoid colon cancer requiring surgical treatment Exclusion Criteria: * The subject is participating in another study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * Patient has a history of abdominal surgery * Patient suffers from a hemostasis disorder (hemophilia, von Willebrand disease, thrombocytopenia) and is on anticoagulant therapy. * Patient whose general condition appears too precarious or is taking corticosteroids or immunosuppressants leading to an unacceptable surgical risk. * Renal insufficiency with clearance \<45ml / min * Known allergy to contrast media * Patient who had treatment of the abdominal aorta or its branches Reported pregnancy (the existence of effective contraception will be verified for women of childbearing age). * Anatomical variant at risk or absence of marginal artery highlighted at the time of arteriography. * Abnormality of the superior mesenteric artery * Historic occlusion of the inferior mesenteric artery
References
Publications (1)
- RESULTFrandon J, Berny L, Prudhomme M, de Forges H, Serrand C, de Oliveira F, Beregi JP, Bertrand MM. Inferior mesenteric artery embolization ahead of rectal cancer surgery: AMIREMBOL pilot study. Br J Surg. 2022 Jul 15;109(8):650-652. doi: 10.1093/bjs/znac071. PMID 35333313