Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level386 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,549 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06929338 | xDRIVE in Metastatic Colorectal Cancer | withdrawn | — | 0 | First Ascent Biomedical Inc.INDUSTRY | 0 | Sep 2, 2026 | clinicaltrials |
| NCT07292285 | The Surveillance Nonoperative Watch & Wait (SNOWW) Rectal Cancer Trial.(SNOWW) | withdrawn | — | 0 | University of Colorado, DenverOTHER | 0 | Jun 9, 2026 | clinicaltrials |
| NCT05331040 | Radiomics in Rectal Cancer | withdrawn | — | 0 | NHS GrampianOTHER_GOV | 1 | Jun 8, 2026 | clinicaltrials |
| NCT06292975 | Exercise for Improving Radiotherapy Efficacy in Rectal Cancer | withdrawn | N/A | 0 | University of HullOTHER | 1 | Mar 6, 2026 | clinicaltrials |
| NCT07223567 | A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer | withdrawn | Phase 2 | 0 | M.D. Anderson Cancer CenterOTHER | 0 | Feb 25, 2026 | clinicaltrials |
| NCT06217016 | Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer Surgery (ICCAUT-2) | withdrawn | N/A | 0 | The First Hospital of Jilin UniversityOTHER | 1 | Aug 28, 2025 | clinicaltrials |
| NCT06895577 | Neoadjuvant Chemoradiotherapy Plus Sintilimab for MSS, Locally Advanced Rectal Cancer- | withdrawn | Phase 2 | 0 | Sun Yat-sen UniversityOTHER | 1 | May 21, 2025 | clinicaltrials |
| NCT06575725 | Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer | withdrawn | Phase 2 | 0 | City of Hope Medical CenterOTHER | 0 | Nov 21, 2024 | clinicaltrials |
| NCT05356897 | Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T Study | withdrawn | Phase 2 | 0 | Academic and Community Cancer Research UnitedOTHER | 1 | Sep 19, 2024 | clinicaltrials |
| NCT05471401 | GI Organ Tracking Via Balloon Applicators | withdrawn | N/A | 0 | Washington University School of MedicineOTHER | 0 | Jun 13, 2024 | clinicaltrials |
| NCT05900648 | Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy (RX-CROME) | withdrawn | Phase 2 | 0 | M.D. Anderson Cancer CenterOTHER | 0 | Apr 29, 2024 | clinicaltrials |
| NCT05356585 | Circulating Tumor DNA to Monitor the Efficacy of Total Neoadjuvant Therapy for Rectal Cancer | withdrawn | — | 0 | Case Comprehensive Cancer CenterOTHER | 1 | Apr 12, 2024 | clinicaltrials |
| NCT04379830 | Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients | withdrawn | N/A | 0 | McMaster UniversityOTHER | 1 | Jan 5, 2024 | clinicaltrials |
| NCT02682485 | Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing(SES-DTA) | withdrawn | Phase 2 | 0 | University of ChicagoOTHER | 0 | Apr 26, 2023 | clinicaltrials |
| NCT04670588 | Response Assessment by Circulating Tumor DNA in Patients With Locally Advanced Rectal Cancer | withdrawn | — | 0 | Medical College of WisconsinOTHER | 1 | Jul 18, 2022 | clinicaltrials |
| NCT04418895 | Neoadjuvant Therapy for Localized Rectal Adenocarcinoma | withdrawn | Phase 2 | 0 | UNC Lineberger Comprehensive Cancer CenterOTHER | 1 | Nov 10, 2021 | clinicaltrials |
| NCT04620473 | Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer | withdrawn | Phase 2 | 0 | Shanghai Minimally Invasive Surgery CenterOTHER | 0 | Sep 28, 2021 | clinicaltrials |
| NCT03633539 | Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer(mSILSC) | withdrawn | N/A | 0 | Ruijin HospitalOTHER | 1 | Sep 10, 2021 | clinicaltrials |
| NCT03257332 | Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After Surgery for Rectal Cancer.(EDFI-Cohort) | withdrawn | — | 0 | Slagelse HospitalOTHER | 1 | Dec 4, 2020 | clinicaltrials |
| NCT01097239 | Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal Pelvic Cancer | withdrawn | Phase 1 / Phase 2 | 0 | Imperial College LondonOTHER | 1 | Nov 20, 2020 | clinicaltrials |
| NCT01302613 | Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma | withdrawn | Phase 1 / Phase 2 | 0 | University of Texas Southwestern Medical CenterOTHER | 1 | Aug 20, 2020 | clinicaltrials |
| NCT03049124 | Exercise for Adults Diagnosed With Rectal Cancer | withdrawn | N/A | 0 | University of OttawaOTHER | 1 | Mar 10, 2020 | clinicaltrials |
| NCT03413930 | Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer | withdrawn | N/A | 0 | Ruijin HospitalOTHER | 1 | Feb 17, 2020 | clinicaltrials |
| NCT03161574 | FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin (CRM) Positive Rectal Cancer | withdrawn | Phase 2 | 0 | Guangxi Medical UniversityOTHER | 1 | Aug 8, 2019 | clinicaltrials |
| NCT00835055 | Expression of Molecular Markers Before and After Neo-adjuvant Chemoradiotherapy in Rectal Cancer | withdrawn | — | 0 | St. Claraspital AGOTHER | 1 | Apr 5, 2019 | clinicaltrials |
| NCT00651677 | Hand Assisted Versus "Pure" Laparoscopic Assisted Proctectomy for Rectal Cancer | withdrawn | N/A | 0 | Weill Medical College of Cornell UniversityOTHER | 1 | Jan 14, 2019 | clinicaltrials |
| NCT01919541 | Mechanistic Prehabilitation | withdrawn | N/A | 0 | Franco CarliOTHER | 1 | Mar 22, 2018 | clinicaltrials |
| NCT03007771 | Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) Used for Mild Hyperthermia | withdrawn | Phase 1 | 0 | Washington University School of MedicineOTHER | 0 | Oct 6, 2017 | clinicaltrials |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal Cancer | withdrawn | Phase 2 | 0 | National Cancer Institute (NCI)NIH | 1 | Apr 4, 2017 | clinicaltrials |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | withdrawn | Phase 2 | 0 | Weill Medical College of Cornell UniversityOTHER | 1 | Jan 25, 2017 | clinicaltrials |
| NCT02586610 | Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer | withdrawn | Phase 2 | 0 | Osama Rahma, MDOTHER | 0 | Jan 20, 2017 | clinicaltrials |
| NCT02287727 | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent Treatment | withdrawn | Phase 2 | 0 | Roswell Park Cancer InstituteOTHER | 1 | Oct 12, 2016 | clinicaltrials |
| NCT02112240 | Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients | withdrawn | N/A | 0 | University of VirginiaOTHER | 1 | Jul 15, 2016 | clinicaltrials |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer | withdrawn | Phase 1 / Phase 2 | 0 | Roswell Park Cancer InstituteOTHER | 1 | May 20, 2016 | clinicaltrials |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer | withdrawn | Phase 2 | 0 | University of Southern CaliforniaOTHER | 1 | May 6, 2015 | clinicaltrials |
| NCT00575640 | Hydralazine as a Demethylating Agent in Rectal Cancer | withdrawn | Phase 1 / Phase 2 | 0 | University of ArkansasOTHER | 0 | Mar 4, 2015 | clinicaltrials |
| NCT01659424 | Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX Chemotherapy for Rectal Cancer(HDRBT) | withdrawn | Phase 2 | 0 | Beth Israel Medical CenterOTHER | 1 | Dec 18, 2014 | clinicaltrials |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy | withdrawn | N/A | 0 | City of Hope Medical CenterOTHER | 1 | Jul 21, 2014 | clinicaltrials |
| NCT01403103 | Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer | withdrawn | Early Phase 1 | 0 | Case Comprehensive Cancer CenterOTHER | 0 | Jan 17, 2014 | clinicaltrials |
| NCT01196000 | Laparoscopic Surgery or Robotic-Assisted Laparoscopic Surgery in Treating Patients With Rectal Cancer That Can Be Removed By Surgery | withdrawn | N/A | 0 | City of Hope Medical CenterOTHER | 0 | Apr 17, 2012 | clinicaltrials |
| NCT00503932 | Proton Therapy With Capecitabine for Rectal Cancer | withdrawn | Phase 1 / Phase 2 | 0 | M.D. Anderson Cancer CenterOTHER | 0 | Mar 22, 2012 | clinicaltrials |
Data updated 22 days agoSource updated Sep 2, 2026source: clinicaltrials