Clinical trial · Interventional
Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery
A Prospective Randomized Clinical Trial Comparing the Transversus Abdominis Plane Block (TAP) Versus Epidural Anesthesia For Enhanced Recovery Pathway Perioperative Management of Pain in Elective Colorectal Surgery
NCT02591407CI-TRIAL-00101858TAPcompletedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary outcome for this study is the Numeric Pain Score (NPS) for elective patients undergoing elective colorectal surgery that have been randomized to transversus abdominis plane block or epidural anesthesia for the management of perioperative pain in elective colorectal surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Colonic Diverticulosis | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Continuous Epidural Analgesia | Procedure | — | UNRESOLVED |
| TAP Block | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- TAP Block- Exparel
- description
- Transversus abdominis plane block utilizing the medication Exparel®
- interventionNames
- Procedure: TAP Block
- type
- ACTIVE_COMPARATOR
- label
- Continuous Epidural Analgesia
- description
- Continuous Epidural Analgesia
- interventionNames
- Procedure: Continuous Epidural Analgesia
Primary outcomes (2)
- measure
- Post-operative Mean Numeric Pain Scale.
- timeFrame
- Post-operative day 0,1,2,3
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing elective open and minimally invasive (laparoscopic and robotic) colon and rectal surgery for colorectal neoplasia, diverticulitis, and other diseases of the colon and rectum; * Surgical procedure either through standard open or minimal invasive approach (laparoscopic or robotic); * Patients \> 18 years of age; * Able to provide informed written consent * Patients capable of completing questionnaires at the time of consent Exclusion Criteria: * Documented allergic reaction to morphine, hydromorphone, lidocaine, bupivicaine and/or fentanyl; * Contra-indication to placement of epidural catheter (spinal stenosis, spinal fusion, elevated International Normalized Ratio (INR), anticoagulation, patient refusal, etc) or TAP block (patient refusal); * Urgent or emergent surgery precluding epidural catheter placement or TAP block; * Systemic Infection contraindicating epidural catheter placement or TAP block; * Unwillingness to participate in follow up assessments; * Prisoners * Pregnant women
References
Publications (1)
- DERIVEDFelling DR, Jackson MW, Ferraro J, Battaglia MA, Albright JJ, Wu J, Genord CK, Brockhaus KK, Bhave RA, McClure AM, Shanker BA, Cleary RK. Liposomal Bupivacaine Transversus Abdominis Plane Block Versus Epidural Analgesia in a Colon and Rectal Surgery Enhanced Recovery Pathway: A Randomized Clinical Trial. Dis Colon Rectum. 2018 Oct;61(10):1196-1204. doi: 10.1097/DCR.0000000000001211. PMID 30192328