Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level386 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,549 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07780305 | ABCSG R07 Rectal Cancer Registry(ABCSG R07 RCR) | not yet recruiting | — | 600 | Austrian Breast & Colorectal Cancer Study GroupNETWORK | 1 | Sep 17, 2026 | clinicaltrials |
| NCT07769853 | Iparomlimab and Tuvonralimab Combined With Chemotherapy and Bevacizumab as Neoadjuvant Therapy for Locally Advanced Rectal Cancer(IT-CABLE) | not yet recruiting | N/A | 56 | Zhejiang UniversityOTHER |
| 0 |
| Sep 15, 2026 |
| clinicaltrials |
| NCT07404228 | Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment(RESTAGE) | not yet recruiting | — | 115 | Institut du Cancer de Montpellier - Val d'AurelleOTHER | 1 | Sep 14, 2026 | clinicaltrials |
| NCT07799740 | Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging(LIRA) | not yet recruiting | N/A | 100 | University of AarhusOTHER | 1 | Sep 11, 2026 | clinicaltrials |
| NCT07805369 | A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer | not yet recruiting | Phase 1 | 60 | DEM BioPharma, Inc.INDUSTRY | 0 | Sep 9, 2026 | clinicaltrials |
| NCT07810114 | Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal Cancer(SPARE) | not yet recruiting | Phase 2 | 52 | Fudan UniversityOTHER | 1 | Sep 9, 2026 | clinicaltrials |
| NCT07811076 | Serine/Glycine-Restricted Diet With Chemoradiotherapy for Rectal Cancer(SG-RCT) | not yet recruiting | Phase 1 / Phase 2 | 140 | Xuelei Ma MDOTHER | 1 | Sep 9, 2026 | clinicaltrials |
| NCT07811128 | Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal Cancer | not yet recruiting | — | 150 | University of California, San FranciscoOTHER | 1 | Sep 9, 2026 | clinicaltrials |
| NCT07779694 | 16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer | not yet recruiting | Phase 2 | 51 | Zhejiang UniversityOTHER | 0 | Sep 8, 2026 | clinicaltrials |
| NCT07341126 | Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal(R-ALERT) | not yet recruiting | — | 30 | University of EdinburghOTHER | 1 | Aug 26, 2026 | clinicaltrials |
| NCT07781774 | Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach | not yet recruiting | N/A | 200 | Washington University School of MedicineOTHER | 1 | Aug 24, 2026 | clinicaltrials |
| NCT07774754 | Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical Trial(RADIANT) | not yet recruiting | Phase 2 | 18 | Sun Yat-sen UniversityOTHER | 1 | Aug 19, 2026 | clinicaltrials |
| NCT07765667 | NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC(CRI-KEV) | not yet recruiting | Phase 2 | 100 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 1 | Aug 14, 2026 | clinicaltrials |
| NCT07764120 | Quality of Life of Patients After Rectal Cancer Resection .(QRAAP) | not yet recruiting | — | 22 | University Hospital, GrenobleOTHER | 0 | Aug 13, 2026 | clinicaltrials |
| NCT07761169 | Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal Cancer | not yet recruiting | N/A | 68 | Peking Union Medical College HospitalOTHER | 0 | Aug 12, 2026 | clinicaltrials |
| NCT07209215 | ctDNA-Informed Management of Early-Stage Rectal Cancer(ULTIMATE) | not yet recruiting | Phase 2 | 200 | University of California, DavisOTHER | 1 | Aug 5, 2026 | clinicaltrials |
| NCT07738042 | To Explore a Single-arm Phase II Study on Intestinal Microbiota Transplantation Combined With Neoadjuvant Immunotherapy and Chemoradiotherapy for Locally Advanced Rectal Cancer Under MSS/pMMR | not yet recruiting | N/A | 46 | Tianjin Medical University Cancer Institute and HospitalOTHER | 1 | Jul 30, 2026 | clinicaltrials |
| NCT07580339 | Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 30 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Jul 28, 2026 | clinicaltrials |
| NCT07726966 | Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial | not yet recruiting | N/A | 120 | Southwest Hospital, ChinaOTHER | 1 | Jul 27, 2026 | clinicaltrials |
| NCT07118800 | Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old(NACRE-2) | not yet recruiting | Phase 3 | 160 | UNICANCEROTHER | 0 | Jul 24, 2026 | clinicaltrials |
| NCT07695519 | SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer(SCARLET) | not yet recruiting | — | 196 | Fondazione Policlinico Universitario Agostino Gemelli IRCCSOTHER | 1 | Jul 10, 2026 | clinicaltrials |
| NCT07691489 | A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer | not yet recruiting | Phase 2 | 27 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Jul 9, 2026 | clinicaltrials |
| NCT07688135 | Quicksilver II Pilot Study | not yet recruiting | N/A | 18 | Mount Sinai Hospital, CanadaOTHER | 0 | Jul 7, 2026 | clinicaltrials |
| NCT05629442 | ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer | not yet recruiting | — | 60 | Massachusetts General HospitalOTHER | 1 | Jul 1, 2026 | clinicaltrials |
| NCT07596290 | Yang et al. Anti-PD-1/CTLA-4 Dual Immunotherapy for LARC(RADICAL) | not yet recruiting | Phase 2 / Phase 3 | 342 | Beijing Friendship HospitalOTHER | 0 | Jun 17, 2026 | clinicaltrials |
| NCT07651007 | Short-course RT Followed by NALIRIFOX Plus Pucotenlimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR | not yet recruiting | Phase 2 | 29 | Wang XinOTHER | 0 | Jun 16, 2026 | clinicaltrials |
| NCT07645118 | Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer(IMPERIA) | not yet recruiting | Phase 2 | 10 | Dr. Te VuongOTHER | 1 | Jun 12, 2026 | clinicaltrials |
| NCT07306390 | Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND)(DIAMOND) | not yet recruiting | — | 1,200 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Jun 9, 2026 | clinicaltrials |
| NCT07622017 | KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal Cancer(K-BOOST) | not yet recruiting | Phase 2 | 24 | Gustave Roussy, Cancer Campus, Grand ParisOTHER | 1 | Jun 2, 2026 | clinicaltrials |
| NCT07595107 | Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer | not yet recruiting | — | 180 | Shandong Cancer Hospital and InstituteOTHER | 1 | May 19, 2026 | clinicaltrials |
| NCT07596732 | Statewide Unified Network for Remote Intervention of Strength and Exercise(SUNRISE) | not yet recruiting | N/A | 120 | AdventHealth Translational Research InstituteOTHER | 0 | May 19, 2026 | clinicaltrials |
| NCT07581626 | Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 60 | Chinese PLA General HospitalOTHER | 1 | May 18, 2026 | clinicaltrials |
| NCT07580027 | Preoperative, Adaptive Radiotherapy Concomitant to Chemotherapy for Rectal Adenocarcinoma (Adaptive Rectal Cancer Trial 02) | not yet recruiting | N/A | 33 | IRCCS San RaffaeleOTHER | 1 | May 12, 2026 | clinicaltrials |
| NCT07552207 | Comparison of [68Ga]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal Cancer(PKUCH-R12) | not yet recruiting | N/A | 30 | Peking University Cancer Hospital & InstituteOTHER | 0 | May 4, 2026 | clinicaltrials |
| NCT07563907 | Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed by Local Excision at Stage I Rectal Cancer(OPTION) | not yet recruiting | N/A | 292 | Seoul National University HospitalOTHER | 1 | May 4, 2026 | clinicaltrials |
| NCT06729645 | External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer(ACO/ARO/AIO-22) | not yet recruiting | N/A | 80 | University Hospital of CologneOTHER | 1 | May 1, 2026 | clinicaltrials |
| NCT07499921 | Clinical and BIOgical Analyses of RECtal Tumors(BIOREC) | not yet recruiting | N/A | 300 | Centre Leon BerardOTHER | 1 | Apr 30, 2026 | clinicaltrials |
| NCT07551479 | SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal Cancer(TORCH-STAR) | not yet recruiting | Phase 3 | 612 | Fudan UniversityOTHER | 1 | Apr 24, 2026 | clinicaltrials |
| NCT07543848 | A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer | not yet recruiting | Phase 2 | 20 | Chongqing University Cancer HospitalOTHER | 1 | Apr 22, 2026 | clinicaltrials |
| NCT07536321 | Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma. | not yet recruiting | — | 46 | Assiut UniversityOTHER | 0 | Apr 17, 2026 | clinicaltrials |
| NCT07527520 | Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial | not yet recruiting | Phase 2 | 165 | Fudan UniversityOTHER | 1 | Apr 14, 2026 | clinicaltrials |
| NCT07516210 | Adaptive Radiotherapy for Safe Hypofractionation(ART-Hypo) | not yet recruiting | Phase 2 | 264 | Centre hospitalier de l'Université de Montréal (CHUM)OTHER | 1 | Apr 7, 2026 | clinicaltrials |
| NCT07509424 | Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced HER2-expressing Rectal Cance | not yet recruiting | Phase 2 | 29 | Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyOTHER | 0 | Apr 3, 2026 | clinicaltrials |
| NCT07483060 | Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer(NG-ST) | not yet recruiting | Phase 4 | 90 | Vastra Gotaland RegionOTHER_GOV | 0 | Mar 19, 2026 | clinicaltrials |
| NCT07472868 | Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer(MEND-IT II) | not yet recruiting | Phase 3 | 394 | J. W. A. BurgerOTHER | 1 | Mar 16, 2026 | clinicaltrials |
| NCT07469306 | Short-Course RT Plus CAPOX and Tislelizumab vs Long-Course CRT Plus Tislelizumab for Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 130 | Fujian Cancer HospitalOTHER_GOV | 1 | Mar 13, 2026 | clinicaltrials |
| NCT07453173 | ONCO-RET: Supervised Resistance Training During Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer(ONCO-RET) | not yet recruiting | N/A | 15 | Fundacion Arturo Lopez PerezOTHER | 1 | Mar 5, 2026 | clinicaltrials |
| NCT07410767 | Advanced Endoscopic Resections for Rectal Neoplasms | not yet recruiting | — | 300 | Jagiellonian UniversityOTHER | 1 | Feb 18, 2026 | clinicaltrials |
| NCT07397442 | Short-Course Radiotherapy Combined With Chemotherapy and Immunotherapy in Mid-Low Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 | 19 | Beijing Friendship HospitalOTHER | 1 | Feb 11, 2026 | clinicaltrials |
| NCT07402486 | A Phase II Prospective Study of Maastro Applicator Brachytherapy for Rectal Cancer | not yet recruiting | Phase 2 | 20 | Siriraj HospitalOTHER | 0 | Feb 11, 2026 | clinicaltrials |
Data updated 12 days agoSource updated Sep 17, 2026source: clinicaltrials