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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
171 stopped studies mapped to Malignant Rectal Neoplasm and descendants · 93% state a reason
Over the 171 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03623464 | RCT of Mobile Apps & FitBit v. Usual Care | N/A | suspended | Aug 9, 2018 | Weill Medical College of Cornell University | Study is paused for interim analysis. | Efficacy / futility |
| NCT06929338 | xDRIVE in Metastatic Colorectal Cancer | — | withdrawn | Apr 16, 2025 | First Ascent Biomedical Inc. | Unable to finalize study agreements | Other (stated, no rule matched) |
| NCT07057089 | Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced… | Phase 2 | suspended | Jul 9, 2025 | Hebei Medical University Fourth Hospital | Suspended due to lack of drug supply: the manufacturer ceased to provide investigational drug… | Drug supply |
| NCT03068403 | Dynamic Contrast Enhanced Ultrasound for Predict and Assess Rectal Cancer Response After…(RECT) | N/A | terminated | Mar 1, 2017 | University Hospital, Bordeaux | target number of inclusion not reached | Other (stated, no rule matched) |
| NCT03941366 | Treatment of Adenocarcinoma of the Rectum With Transanal Local Excision for Complete… | N/A | terminated | May 7, 2019 | Henry Ford Health System | Lack of financial support | Funding |
| NCT05526079 | Watchful Waiting for Complete Responders to Therapy in Rectal Cancer | N/A | terminated | Sep 2, 2022 | Henry Ford Health System | Lack of financial support | Funding |
| NCT05400122 | Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming… | Phase 1 | suspended | Jun 1, 2022 | David Wald | Drugs unavailable | Other (stated, no rule matched) |
| NCT01871571 | Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating… | Phase 2 | terminated | Jun 6, 2013 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT01148056 | Intensity Modulated Radiation Therapy (IMRT) for Patients With Rectal Cancer | N/A | terminated | Jun 22, 2010 | Massachusetts General Hospital | The study was closed to enrollment due to slow accrual. | Enrollment / accrual |
| NCT07292285 | The Surveillance Nonoperative Watch & Wait (SNOWW) Rectal Cancer Trial.(SNOWW) | — | withdrawn | Dec 18, 2025 | University of Colorado, Denver | Sponsor decided not to move forward with the site. | Sponsor / business decision |
| NCT05331040 | Radiomics in Rectal Cancer | — | withdrawn | Apr 15, 2022 | NHS Grampian | Ill health of CI | Other (stated, no rule matched) |
| NCT03745326 | Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor… | Phase 1 / Phase 2 | terminated | Nov 19, 2018 | National Cancer Institute (NCI) | Study was closed due to lack of accrual and study outcomes overlapped with another protocol's… | Enrollment / accrual |
| NCT06149741 | Defunctioning Left-sided Colostomy in Low Anterior Resection for Rectal Cancer(STOMALEFT) | N/A | terminated | Nov 29, 2023 | Umeå University | Logistical difficulties at study sites. 16/20 patients included. | Other (stated, no rule matched) |
| NCT04336202 | Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy(Whistle) | N/A | suspended | Apr 7, 2020 | Sir Mortimer B. Davis - Jewish General Hospital | Issues with applicator | Other (stated, no rule matched) |
| NCT03876561 | "Impact of Pelvic Floor Prehabilitation Using Biofeedback on the Severity of the Low…(CONTICARE) | N/A | terminated | Mar 15, 2019 | Nantes University Hospital | lack of inclusion | Other (stated, no rule matched) |
| NCT02151019 | Pre-operative 3-DCRT vs IMRT for Locally Advanced Rectal Cancer(TRI-LARC) | Phase 1 / Phase 2 | terminated | May 30, 2014 | Cancer Trials Ireland | Due to futility | Efficacy / futility |
| NCT06181201 | Association Between the Composition of the Intestinal Microbiota and Tumor Response in…(Neo-Flo-Rect) | — | terminated | Dec 26, 2023 | Centre Oscar Lambret | Lack of eligible patients | Other (stated, no rule matched) |
| NCT06292975 | Exercise for Improving Radiotherapy Efficacy in Rectal Cancer | N/A | withdrawn | Mar 5, 2024 | University of Hull | Although patients were screened, only two met the eligibility criteria within the available… | Enrollment / accrual |
| NCT07223567 | A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing… | Phase 2 | withdrawn | Nov 3, 2025 | M.D. Anderson Cancer Center | 0 participants enrolled | Enrollment / accrual |
| NCT06625515 | First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or… | Phase 1 | terminated | Oct 3, 2024 | Accent Therapeutics | The study was terminated by sponsor based on the adverse event profile. | Safety / toxicity |
| NCT05358704 | Preoperative ChemoRadiation And FOLFOXIRI for Rectal Cancer (CRAFTER) for Rectal Cancer | Phase 2 | suspended | May 3, 2022 | Rutgers, The State University of New Jersey | no slots available | Other (stated, no rule matched) |
| NCT04827732 | Hypofractionated Pencil-Beam Scanning Intensity-modulated Proton Therapy (IMPT) in…(IMPARC) | N/A | terminated | Apr 1, 2021 | Washington University School of Medicine | Slow enrollment | Enrollment / accrual |
| NCT03765736 | Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal… | — | terminated | Dec 5, 2018 | Academic and Community Cancer Research United | Low accrual | Enrollment / accrual |
| NCT06217016 | Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer… | N/A | withdrawn | Jan 22, 2024 | The First Hospital of Jilin University | The ICCAUT-1 trial failed to demonstrate the superiority of the ICCAUT strategy in urinary… | Sponsor / business decision |
| NCT05591534 | Endorectal Brachytherapy for Rectal Cancer(ICUREC) | Phase 2 | suspended | Oct 24, 2022 | University Hospital, Bordeaux | Unknown time frame for availability of new endorectal probes | Other (stated, no rule matched) |
| NCT05010850 | SafeHeal Colovac Colorectal Anastomosis Protection Device Evaluation (SAFE-2) Pivotal…(SAFE-2) | N/A | terminated | Aug 18, 2021 | SafeHeal Inc | Voluntary and temporary suspension of enrollment. | Enrollment / accrual |
| NCT06895577 | Neoadjuvant Chemoradiotherapy Plus Sintilimab for MSS, Locally Advanced Rectal Cancer- | Phase 2 | withdrawn | Mar 26, 2025 | Sun Yat-sen University | Due to errors in the previously submitted modification, we request to withdraw it and will submit a… | Other (stated, no rule matched) |
| NCT04108481 | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer(iRE-C) | Phase 1 | terminated | Sep 30, 2019 | University of Iowa | DSMC-directed closure | Other (stated, no rule matched) |
| NCT05179837 | Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal… | N/A | terminated | Jan 5, 2022 | Washington University School of Medicine | Low accrual | Enrollment / accrual |
| NCT04316013 | Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: the VAPOR-C Trial | Phase 3 | terminated | Mar 20, 2020 | Peter MacCallum Cancer Centre, Australia | Not meeting recruitment timelines | Enrollment / accrual |
| NCT04406857 | Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy… | Phase 1 | terminated | May 29, 2020 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT04213794 | Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for…(TOASTIT) | Early Phase 1 | terminated | Dec 30, 2019 | Mayo Clinic | slow accrual | Enrollment / accrual |
| NCT05164315 | Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0 | N/A | terminated | Dec 20, 2021 | Seoul National University Hospital | the high proportion of patients requiring TME(control group) suggests that proceeding with a… | Other (stated, no rule matched) |
| NCT06575725 | Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the… | Phase 2 | withdrawn | Aug 28, 2024 | City of Hope Medical Center | Abandoned 9/23/24 | Other (stated, no rule matched) |
| NCT05356897 | Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive… | Phase 2 | withdrawn | May 2, 2022 | Academic and Community Cancer Research United | no sites were regulatory ready and the SC took the study to a different group. | Other (stated, no rule matched) |
| NCT05471401 | GI Organ Tracking Via Balloon Applicators | N/A | withdrawn | Jul 22, 2022 | Washington University School of Medicine | Low accrual | Enrollment / accrual |
| NCT03300544 | Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating… | Phase 1 | terminated | Oct 3, 2017 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT05900648 | Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With… | Phase 2 | withdrawn | Jun 12, 2023 | M.D. Anderson Cancer Center | 0 participant accrual | Enrollment / accrual |
| NCT03402477 | "Watch and Wait" After Neo-adjuvant Chemoradiotherapy for Primary Locally Advanced Rectal…(NORWAIT) | — | terminated | Jan 18, 2018 | Helse Stavanger HF | Suspicion of adverse events | Safety / toxicity |
| NCT05356585 | Circulating Tumor DNA to Monitor the Efficacy of Total Neoadjuvant Therapy for Rectal… | — | withdrawn | May 2, 2022 | Case Comprehensive Cancer Center | Sponsor already published research that was to be obtained from this study. | Other (stated, no rule matched) |
| NCT04812743 | Colorectal Health Research Champions | N/A | terminated | Mar 24, 2021 | Virginia Commonwealth University | End of grant funding | Funding |
| NCT01605318 | Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer | Phase 1 / Phase 2 | terminated | May 24, 2012 | Gilead Sciences | not stated | Not stated |
| NCT01769222 | Ipilimumab and Local Radiation for Selected Solid Tumors | Phase 1 | terminated | Jan 16, 2013 | Stanford University | Planned Future Study | Other (stated, no rule matched) |
| NCT04379830 | Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients | N/A | withdrawn | May 8, 2020 | McMaster University | There were no patients recruited during the trial period. This was a result of: 1) COVID-19… | COVID-19 / pandemic |
| NCT04558684 | Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer | Phase 1 / Phase 2 | suspended | Sep 22, 2020 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT03592641 | Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal… | Phase 2 | terminated | Jul 19, 2018 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT00745134 | Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating… | Phase 2 | terminated | Sep 3, 2008 | M.D. Anderson Cancer Center | The trial was stopped early because there was only one patient with pCR among the first 15 patients… | Other (stated, no rule matched) |
| NCT04066894 | Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal… | Phase 2 | terminated | Aug 26, 2019 | M.D. Anderson Cancer Center | Due to Issues Enrolling Patients | Enrollment / accrual |
| NCT04139967 | Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer | N/A | terminated | Oct 25, 2019 | University of Rochester | recruitment rates were too low | Enrollment / accrual |
| NCT00303628 | Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III… | Phase 3 | terminated | Mar 17, 2006 | ECOG-ACRIN Cancer Research Group | The study was terminated before reaching its accrual goal due to slow accrual. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 21 hours agoSource updated Sep 28, 2026source: clinicaltrials