Olaparib

Pancreatic Adenocarcinoma,Triple-Negative Breast Carcinoma

← predicts response to

BRCA2 Loss-of-function

3 source records aggregated

sensitivity

Curated

Pancreatic Adenocarcinoma,Triple-Negative Breast Carcinoma

← predicts response to

BRCA1 Loss-of-functionloss_of_heterozygosity

3 source records aggregated

sensitivity

Curated

Castration-Resistant Prostate Carcinoma,Malignant Ovarian Neoplasm

← predicts response to

BRCA2 Mutationother

2 source records aggregated

sensitivity

Curated

← predicts response to

RAD51D Mutationother

sensitivity

Curated

← predicts response to

RAD51B Mutationother

sensitivity

Curated

← predicts response to

CHEK1 Mutationother

sensitivity

Curated

← predicts response to

BARD1 Mutationother

sensitivity

Curated

← predicts response to

BRIP1 Mutationother

sensitivity

Curated

← predicts response to

RAD54L Mutationother

sensitivity

Curated

← predicts response to

CHEK2 mutationother

sensitivity

Curated

← predicts response to

CDK12 Mutationother

sensitivity

Curated

← predicts response to

ATM Mutationother

sensitivity

Curated

← predicts response to

PALB2 Mutationother

sensitivity

Curated

Breast Carcinoma,Lung Carcinoma,Malignant Biliary Tract Neoplasm+6

← predicts response to

BRCA1 Mutationother

11 source records aggregated

sensitivity

Curated

Olaparib targets …TARGETS3 of 3
→ targets	PARP2	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PARP1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PARP3	—	INHIBITOR	—	1	Curated	chembl	graph →

Olaparib targets …TARGETS3 of 3

→ targets

PARP2

—

INHIBITOR

—

Curated

→ targets

PARP1

—

INHIBITOR

—

Curated

→ targets

PARP3

—

INHIBITOR

—

Curated

Olaparib investigated for …INVESTIGATED_FOR79 of 79show fewer
→ investigated for	Castration-Resistant Prostate Carcinomasubtype 12 source records aggregated	supports	A	Castration-Resistant Prostate Carcinoma	12	Curated	civic	graph →
→ investigated for	Malignant Ovarian Neoplasmcancer 3 source records aggregated	supports	A	Malignant Ovarian Neoplasm	3	Curated	civic	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype 2 source records aggregated	supports	A	Triple-Negative Breast Carcinoma	2	Curated	civic	graph →
→ investigated for	Pancreatic Adenocarcinomasubtype 2 source records aggregated	supports	A	Pancreatic Adenocarcinoma	2	Curated	civic	graph →
→ investigated for	Malignant Ovarian Neoplasmcancer 6 source records aggregated	supports	B	Malignant Ovarian Neoplasm	6	Curated	civic	graph →
→ investigated for	Malignant Prostate Neoplasmcancer 3 source records aggregated	supports	B	Malignant Prostate Neoplasm	3	Curated	civic	graph →
→ investigated for	Malignant Pancreatic Neoplasmcancer 2 source records aggregated	supports	B	Malignant Pancreatic Neoplasm	2	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family 2 source records aggregated	supports	B	Malignant Neoplasm	2	Curated	civic	graph →
→ investigated for	Malignant Gastric Neoplasmcancer	supports	B	Malignant Gastric Neoplasm	1	Curated	civic	graph →
→ investigated for	Solid Neoplasmcancer_family	supports	B	Solid Neoplasm	1	Curated	civic	graph →
→ investigated for	Malignant Uterine Neoplasmsubtype	supports	B	Malignant Uterine Neoplasm	1	Curated	civic	graph →
→ investigated for	Lung Carcinomasubtype	supports	B	Lung Carcinoma	1	Curated	civic	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	supports	B	Triple-Negative Breast Carcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Biliary Tract Neoplasmsubtype	supports	B	Malignant Biliary Tract Neoplasm	1	Curated	civic	graph →
→ investigated for	Breast Carcinomasubtype	supports	B	Breast Carcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Breast Neoplasmcancer_family	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	4	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	4	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Ovarian Neoplasmsubtype	unknown	4	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Malignant Prostate Neoplasmcancer 5 source records aggregated	supports	C	Malignant Prostate Neoplasm	5	Curated	civic	graph →
→ investigated for	Glioblastomasubtype	supports	C	Glioblastoma	1	Curated	civic	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	3	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	3	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	unknown	3	Lung Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Endometrial Neoplasmsubtype	unknown	3	Endometrial Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	3	Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	3	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Prostate Neoplasmsubtype	unknown	3	Prostate Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Small Cell Carcinomasubtype 2 source records aggregated	supports	D	Lung Small Cell Carcinoma	2	Curated	civic	graph →
→ investigated for	Ovarian Endometrioid Adenocarcinomasubtype	supports	D	Ovarian Endometrioid Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Breast Carcinomasubtype	supports	D	Breast Carcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family	supports	D	Malignant Neoplasm	1	Curated	civic	graph →
→ investigated for	Leukemiacancer_family	supports	D	Leukemia	1	Curated	civic	graph →
→ investigated for	Malignant Peripheral Nerve Sheath Tumorsubtype	supports	D	Malignant Peripheral Nerve Sheath Tumor	1	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	D	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Malignant Mesotheliomacancer_family	supports	D	Malignant Mesothelioma	1	Curated	civic	graph →
→ investigated for	Mantle Cell Lymphomahematologic_malignancy	supports	D	Mantle Cell Lymphoma	1	Curated	civic	graph →
→ investigated for	Gastric Adenocarcinomasubtype	supports	D	Gastric Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Ovarian Serous Adenocarcinomasubtype	supports	D	Ovarian Serous Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Hematopoietic and Lymphoid Cell Neoplasmcancer_family	supports	D	Hematopoietic and Lymphoid Cell Neoplasm	1	Curated	civic	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	2	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Myeloid Leukemiahematologic_malignancy	unknown	2	Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Uveal Melanomasubtype	unknown	2	Uveal Melanoma	1	Curated	chembl	graph →
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	2	Acute Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Leiomyosarcomasubtype	unknown	2	Leiomyosarcoma	1	Curated	chembl	graph →
→ investigated for	Adrenal Gland Pheochromocytomasubtype	unknown	2	Adrenal Gland Pheochromocytoma	1	Curated	chembl	graph →
→ investigated for	Peripheral T-Cell Lymphoma, Not Otherwise Specifiedhematologic_malignancy	unknown	2	Peripheral T-Cell Lymphoma, Not Otherwise Specified	1	Curated	chembl	graph →
→ investigated for	Myelodysplastic Syndromehematologic_malignancy	unknown	2	Myelodysplastic Syndrome	1	Curated	chembl	graph →
→ investigated for	Ovarian Carcinomasubtype	unknown	2	Ovarian Carcinoma	1	Curated	chembl	graph →
→ investigated for	Carcinosarcomasubtype	unknown	2	Carcinosarcoma	1	Curated	chembl	graph →
→ investigated for	Gliomasubtype	unknown	2	Glioma	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	2	Melanoma	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	2	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	2	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →
→ investigated for	Osteosarcomasubtype	unknown	2	Osteosarcoma	1	Curated	chembl	graph →
→ investigated for	Bile Duct Neoplasmsubtype	unknown	2	Bile Duct Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cholangiocarcinomasubtype	unknown	2	Cholangiocarcinoma	1	Curated	chembl	graph →
→ investigated for	Angiosarcomasubtype	unknown	2	Angiosarcoma	1	Curated	chembl	graph →
→ investigated for	Peritoneal Neoplasmcancer_family	unknown	2	Peritoneal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Fallopian Tube Neoplasmsubtype	unknown	2	Fallopian Tube Neoplasm	1	Curated	chembl	graph →
→ investigated for	Malignant Mesotheliomacancer_family	unknown	2	Malignant Mesothelioma	1	Curated	chembl	graph →
→ investigated for	Renal Cell Carcinomasubtype	unknown	2	Renal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	2	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Glioblastomasubtype	unknown	2	Glioblastoma	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	2	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Ewing Sarcomasubtype	unknown	2	Ewing Sarcoma	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	2	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	1	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype	unknown	1	Head and Neck Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Serous Cystadenocarcinomahistology	unknown	1	Serous Cystadenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	1	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Uterine Neoplasmsubtype	unknown	1	Uterine Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neuroendocrine Tumorsubtype	unknown	1	Neuroendocrine Tumor	1	Curated	chembl	graph →
→ investigated for	Central Nervous System Neoplasmcancer_family	unknown	1	Central Nervous System Neoplasm	1	Curated	chembl	graph →
→ investigated for	Rhabdomyosarcomasubtype	unknown	1	Rhabdomyosarcoma	1	Curated	chembl	graph →
→ investigated for	Breast Inflammatory Carcinomasubtype	unknown	1	Breast Inflammatory Carcinoma	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	1	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →

Olaparib investigated for …INVESTIGATED_FOR79 of 79show fewer

→ investigated for

Castration-Resistant Prostate Carcinomasubtype

12 source records aggregated

supports

Curated

Malignant Ovarian Neoplasm

→ investigated for

Malignant Ovarian Neoplasmcancer

3 source records aggregated

supports

Curated

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

2 source records aggregated

supports

Curated

Pancreatic Adenocarcinoma

→ investigated for

Pancreatic Adenocarcinomasubtype

2 source records aggregated

supports

Curated

Malignant Ovarian Neoplasm

→ investigated for

Malignant Ovarian Neoplasmcancer

6 source records aggregated

supports

Curated

Malignant Prostate Neoplasm

→ investigated for

Malignant Prostate Neoplasmcancer

3 source records aggregated

supports

Curated

Malignant Pancreatic Neoplasm

→ investigated for

Malignant Pancreatic Neoplasmcancer

2 source records aggregated

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

2 source records aggregated

supports

Malignant Neoplasm

Curated

Malignant Gastric Neoplasm

→ investigated for

Malignant Gastric Neoplasmcancer

supports

Curated

→ investigated for

Solid Neoplasmcancer_family

supports

Solid Neoplasm

Curated

Malignant Uterine Neoplasm

→ investigated for

Malignant Uterine Neoplasmsubtype

supports

Curated

→ investigated for

Lung Carcinomasubtype

supports

Lung Carcinoma

Curated

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

supports

Curated

Malignant Biliary Tract Neoplasm

→ investigated for

Malignant Biliary Tract Neoplasmsubtype

supports

Curated

→ investigated for

Breast Carcinomasubtype

supports

Breast Carcinoma

Curated

Malignant Breast Neoplasm

→ investigated for

Malignant Breast Neoplasmcancer_family

supports

Curated

→ investigated for

Pancreatic Neoplasmsubtype

unknown

Pancreatic Neoplasm

Curated

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

→ investigated for

Ovarian Neoplasmsubtype

unknown

Ovarian Neoplasm

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

Malignant Prostate Neoplasm

→ investigated for

Malignant Prostate Neoplasmcancer

5 source records aggregated

supports

Curated

→ investigated for

Glioblastomasubtype

supports

Glioblastoma

Curated

→ investigated for

Lung Neoplasmcancer_family

unknown

Lung Neoplasm

Curated

→ investigated for

Gastric Neoplasmcancer_family

unknown

Gastric Neoplasm

Curated

→ investigated for

Lung Small Cell Carcinomasubtype

unknown

Curated

→ investigated for

Endometrial Neoplasmsubtype

unknown

Endometrial Neoplasm

Curated

→ investigated for

Carcinomacancer_family

unknown

Carcinoma

Curated

Lung Non-Small Cell Carcinoma

→ investigated for

Lung Non-Small Cell Carcinomasubtype

unknown

Curated

→ investigated for

Prostate Neoplasmsubtype

unknown

Prostate Neoplasm

Curated

→ investigated for

Lung Small Cell Carcinomasubtype

2 source records aggregated

supports

Curated

Ovarian Endometrioid Adenocarcinoma

→ investigated for

Ovarian Endometrioid Adenocarcinomasubtype

supports

Curated

→ investigated for

Breast Carcinomasubtype

supports

Breast Carcinoma

Curated

→ investigated for

Malignant Neoplasmcancer_family

supports

Malignant Neoplasm

Curated

→ investigated for

Leukemiacancer_family

supports

Leukemia

Curated

Malignant Peripheral Nerve Sheath Tumor

→ investigated for

Malignant Peripheral Nerve Sheath Tumorsubtype

supports

Curated

Malignant Colorectal Neoplasm

→ investigated for

Malignant Colorectal Neoplasmsubtype

supports

Curated

→ investigated for

Malignant Mesotheliomacancer_family

supports

Malignant Mesothelioma

Curated

→ investigated for

Mantle Cell Lymphomahematologic_malignancy

supports

Mantle Cell Lymphoma

Curated

→ investigated for

Gastric Adenocarcinomasubtype

supports

Gastric Adenocarcinoma

Curated

Ovarian Serous Adenocarcinoma

→ investigated for

Ovarian Serous Adenocarcinomasubtype

supports

Curated

Hematopoietic and Lymphoid Cell Neoplasm

→ investigated for

Hematopoietic and Lymphoid Cell Neoplasmcancer_family

supports

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Colorectal Neoplasm

Curated

→ investigated for

Myeloid Leukemiahematologic_malignancy

unknown

Myeloid Leukemia

Curated

→ investigated for

Uveal Melanomasubtype

unknown

Uveal Melanoma

Curated

→ investigated for

Acute Myeloid Leukemiahematologic_malignancy

unknown

Acute Myeloid Leukemia

Curated

→ investigated for

Leiomyosarcomasubtype

unknown

Leiomyosarcoma

Curated

Adrenal Gland Pheochromocytoma

→ investigated for

Adrenal Gland Pheochromocytomasubtype

unknown

Curated

Peripheral T-Cell Lymphoma, Not Otherwise Specified

→ investigated for

Peripheral T-Cell Lymphoma, Not Otherwise Specifiedhematologic_malignancy

unknown

Curated

→ investigated for

Myelodysplastic Syndromehematologic_malignancy

unknown

Myelodysplastic Syndrome

Curated

→ investigated for

Ovarian Carcinomasubtype

unknown

Ovarian Carcinoma

Curated

→ investigated for

Carcinosarcomasubtype

unknown

Carcinosarcoma

Curated

→ investigated for

Gliomasubtype

unknown

Glioma

Curated

→ investigated for

Melanomacancer_family

unknown

Melanoma

Curated

→ investigated for

Cervical Neoplasmsubtype

unknown

Cervical Neoplasm

Curated

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

unknown

Curated

→ investigated for

Osteosarcomasubtype

unknown

Osteosarcoma

Curated

→ investigated for

Bile Duct Neoplasmsubtype

unknown

Bile Duct Neoplasm

Curated

→ investigated for

Cholangiocarcinomasubtype

unknown

Cholangiocarcinoma

Curated

→ investigated for

Angiosarcomasubtype

unknown

Angiosarcoma

Curated

→ investigated for

Peritoneal Neoplasmcancer_family

unknown

Peritoneal Neoplasm

Curated

→ investigated for

Fallopian Tube Neoplasmsubtype

unknown

Fallopian Tube Neoplasm

Curated

→ investigated for

Malignant Mesotheliomacancer_family

unknown

Malignant Mesothelioma

Curated

→ investigated for

Renal Cell Carcinomasubtype

unknown

Renal Cell Carcinoma

Curated

→ investigated for

Bladder Neoplasmsubtype

unknown

Bladder Neoplasm

Curated

→ investigated for

Glioblastomasubtype

unknown

Glioblastoma

Curated

→ investigated for

Sarcomacancer_family

unknown

Sarcoma

Curated

→ investigated for

Ewing Sarcomasubtype

unknown

Ewing Sarcoma

Curated

→ investigated for

Squamous Cell Carcinomahistology

unknown

Squamous Cell Carcinoma

Curated

→ investigated for

Esophageal Neoplasmcancer_family

unknown

Esophageal Neoplasm

Curated

Head and Neck Squamous Cell Carcinoma

→ investigated for

Head and Neck Squamous Cell Carcinomasubtype

unknown

Curated

Serous Cystadenocarcinoma

→ investigated for

Serous Cystadenocarcinomahistology

unknown

Curated

Chronic Lymphocytic Leukemia

→ investigated for

Chronic Lymphocytic Leukemiahematologic_malignancy

unknown

Curated

→ investigated for

Uterine Neoplasmsubtype

unknown

Uterine Neoplasm

Curated

→ investigated for

Neuroendocrine Tumorsubtype

unknown

Neuroendocrine Tumor

Curated

Central Nervous System Neoplasm

→ investigated for

Central Nervous System Neoplasmcancer_family

unknown

Curated

→ investigated for

Rhabdomyosarcomasubtype

unknown

Rhabdomyosarcoma

Curated

Breast Inflammatory Carcinoma

→ investigated for

Breast Inflammatory Carcinomasubtype

unknown

Curated

→ investigated for

Head and Neck Neoplasmcancer_family

unknown

Head and Neck Neoplasm

Curated

→ investigated for

Lymphomacancer_family

unknown

Lymphoma

Curated

Malignant Ovarian Neoplasm

Olaparib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 207show all (up to 200)
→ investigated in trials for	Malignant Ovarian Neoplasmcancer 53 trials (18 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Ovarian Neoplasm	53	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasmcancer_family 41 trials (21 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	41	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasmcancer_family 31 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	31	Observed	clinicaltrials	graph →
→ investigated in trials for	Castration-Resistant Prostate Carcinomasubtype 21 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Castration-Resistant Prostate Carcinoma	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Triple-Negative Breast Carcinomamolecular_subtype 21 trials (11 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Triple-Negative Breast Carcinoma	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Prostate Neoplasmcancer 20 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Prostate Neoplasm	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Ovarian Carcinomasubtype 19 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ovarian Carcinoma	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Solid Neoplasm 16 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Solid Neoplasm	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 13 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Small Cell Carcinomasubtype 13 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Fallopian Tube Neoplasm 13 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Fallopian Tube Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasmcancer 13 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Primary Peritoneal Carcinoma 13 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Primary Peritoneal Carcinoma	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 12 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Fallopian Tube Carcinoma 11 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Fallopian Tube Carcinoma	11	Observed	clinicaltrials	graph →

Olaparib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 207show all (up to 200)

→ investigated in trials for

Malignant Ovarian Neoplasmcancer

53 trials (18 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Malignant Breast Neoplasm

→ investigated in trials for

Malignant Breast Neoplasmcancer_family

41 trials (21 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Solid Neoplasmcancer_family

31 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

→ investigated in trials for

Castration-Resistant Prostate Carcinomasubtype

21 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Triple-Negative Breast Carcinomamolecular_subtype

21 trials (11 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Malignant Prostate Neoplasm

→ investigated in trials for

Malignant Prostate Neoplasmcancer

20 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Ovarian Carcinomasubtype

19 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Ovarian Carcinoma

Observed

→ investigated in trials for

Malignant Solid Neoplasm

16 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Solid Neoplasm

Observed

→ investigated in trials for

Breast Neoplasmcancer_family

13 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Breast Neoplasm

Observed

→ investigated in trials for

Lung Small Cell Carcinomasubtype

13 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Malignant Fallopian Tube Neoplasm

→ investigated in trials for

13 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Fallopian Tube Neoplasm

Observed

Malignant Pancreatic Neoplasm

→ investigated in trials for

Malignant Pancreatic Neoplasmcancer

13 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Primary Peritoneal Carcinoma

→ investigated in trials for

13 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Primary Peritoneal Carcinoma

Observed

Lung Non-Small Cell Carcinoma

→ investigated in trials for

Lung Non-Small Cell Carcinomasubtype

12 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Fallopian Tube Carcinoma

11 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Fallopian Tube Carcinoma

Observed

Olaparib studied in …STUDIED_INderived10 of 351show all (up to 200)
→ studied in	NCT03976323Phase 3 · completed Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006) · 351 trials list this drug (156 active)	—	—	Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04086485Phase 1/Phase 2 · recruiting Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET) · 351 trials list this drug (156 active)	—	—	Neuroendocrine Neoplasm,Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05564377Phase 2 · recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 351 trials list this drug (156 active)	—	—	Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02498613Phase 2 · active not recruiting A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors · 351 trials list this drug (156 active)	—	—	Malignant Breast Neoplasm,Malignant Solid Neoplasm,Lung Non-Small Cell Carcinoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT03568656Phase 1/Phase 2 · completed Study to Evaluate CCS1477 in Advanced Tumours · 351 trials list this drug (156 active)	—	—	Solid Neoplasm,Malignant Breast Neoplasm,Lung Non-Small Cell Carcinoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT03741426Phase 2 · recruiting WIRE - Novel Treatments in Renal Cell Cancer · 351 trials list this drug (156 active)	—	—	Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04858334Phase 2 · recruiting APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation · 351 trials list this drug (156 active)	—	—	Pancreatic Carcinoma,Pancreatic Squamous Cell Carcinoma,Pancreatic Acinar Cell Carcinoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT06966700Phase 3 · recruiting A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032) · 351 trials list this drug (156 active)	—	—	Breast Neoplasm,Triple-Negative Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04417062Phase 2 · active not recruiting Olaparib With Ceralasertib in Recurrent Osteosarcoma · 351 trials list this drug (156 active)	—	—	Osteosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04624204Phase 3 · active not recruiting Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013) · 351 trials list this drug (156 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →

Olaparib studied in …STUDIED_INderived10 of 351show all (up to 200)

→ studied in

NCT03976323Phase 3 · completed

Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006) · 351 trials list this drug (156 active)

—

Carcinoma

Observed

Neuroendocrine Neoplasm,Neuroendocrine Tumor

→ studied in

NCT04086485Phase 1/Phase 2 · recruiting

Lu-177-DOTATATE (Lutathera) in Combination With Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET) · 351 trials list this drug (156 active)

—

Observed

Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2

→ studied in

NCT05564377Phase 2 · recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 351 trials list this drug (156 active)

—

Observed

Malignant Breast Neoplasm,Malignant Solid Neoplasm,Lung Non-Small Cell Carcinoma+2

→ studied in

NCT02498613Phase 2 · active not recruiting

A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors · 351 trials list this drug (156 active)

—

Observed

Solid Neoplasm,Malignant Breast Neoplasm,Lung Non-Small Cell Carcinoma+1

→ studied in

NCT03568656Phase 1/Phase 2 · completed

Study to Evaluate CCS1477 in Advanced Tumours · 351 trials list this drug (156 active)

—

Observed

→ studied in

NCT03741426Phase 2 · recruiting

WIRE - Novel Treatments in Renal Cell Cancer · 351 trials list this drug (156 active)

—

Renal Cell Carcinoma

Observed

Pancreatic Carcinoma,Pancreatic Squamous Cell Carcinoma,Pancreatic Acinar Cell Carcinoma+2

→ studied in

NCT04858334Phase 2 · recruiting

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation · 351 trials list this drug (156 active)

—

Observed

Breast Neoplasm,Triple-Negative Breast Carcinoma

→ studied in

NCT06966700Phase 3 · recruiting

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032) · 351 trials list this drug (156 active)

—

Observed

→ studied in

NCT04417062Phase 2 · active not recruiting

Olaparib With Ceralasertib in Recurrent Osteosarcoma · 351 trials list this drug (156 active)

—

Osteosarcoma

Observed

→ studied in

NCT04624204Phase 3 · active not recruiting

Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013) · 351 trials list this drug (156 active)

—

Observed