Gene
PARP1
poly(ADP-ribose) polymerase 1
Explore in graph →CI-GENE-00018911HGNC:270 ENSG00000143799 NCBI 142 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (3)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26650448
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PARP1 OVEREXPRESSION3 | ||||||||
| Olaparib | Malignant Peripheral Nerve Sheath Tumor | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID7016The majority of MPNST samples were positive for PARP staining. Overall, moderate to high expression of PARP1 and PARP2 was observed (Table 1)....Overall, treatment continued for 60 d at which point 5 … (full text at CIViC) PMID 26650448 · Kivlin et al., 2016 · Open in CIViC | civic |
| 〃 | Malignant Breast Neoplasm | Predictive | D | Supports Resistance | 3 | submitted | EID7867Researchers compared biomarkers in breast cancer stem cell (BCSC) enriched and mature cancer cell populations from human breast cancer cell lines. Overexpression of PARP1 was found in BCSC enriched p… (full text at CIViC) PMID 25144364 · Gilabert et al., 2014 · | |
Cohorts
Alteration frequency by cohort (58)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 34635660
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| RAD51B Associated Mixed Cancers (MSK, NPJ Breast Cancer 2021) mixed_msk_tcga_2021 | unmapped | Ssm | 2 | 17 |
Literature
Linked publications (1)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
· Cancer Biol Ther · 2016 · PMID 26650448 · validated civic_curation pubmed