ATM Mutation

Loading variant…

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Castration-Resistant Prostate Carcinoma3
ATM Mutation	Olaparib	Predictive	A	Supports Sensitivity Response	4	accepted	EID8505 This study (PMID 32343890) by de Bono et al, is a randomized, open-label, phase 3 trial evaluating the PARP inhibitor olaparib in 387 men with metastatic castration-resistant prostate cancer (mCRPC) w… (full text at CIViC) PMID 32343890 · de Bono et al., 2020 · Open in CIViC	civic
ATM Mutation	Rucaparib	Predictive	B	Does Not Support Sensitivity Response	4	accepted	EID13268 In the exploratory ATM subgroup of the randomized phase III TRITON3 trial, 103 patients with metastatic castration-resistant prostate cancer harboring germline or somatic deleterious ATM alterations w… (full text at CIViC) PMID 36795891 · Fizazi et al., 2023 · Open in CIViC

Molecular profile

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

Castration-Resistant Prostate Carcinoma3

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

accepted

EID8505

This study (PMID 32343890) by de Bono et al, is a randomized, open-label, phase 3 trial evaluating the PARP inhibitor olaparib in 387 men with metastatic castration-resistant prostate cancer (mCRPC) w… (full text at CIViC)

PMID 32343890 · de Bono et al., 2020 · Open in CIViC

civic

ATM Mutation

Rucaparib

Predictive

Does Not Support Sensitivity Response

accepted

EID13268

In the exploratory ATM subgroup of the randomized phase III TRITON3 trial, 103 patients with metastatic castration-resistant prostate cancer harboring germline or somatic deleterious ATM alterations w… (full text at CIViC)

PMID 36795891 · Fizazi et al., 2023 · Open in CIViC

Chronic Lymphocytic Leukemia3
ATM Mutation	(prognostic)	Prognostic	A	Supports Poor Outcome	5	accepted	EID1539 In a study of 406 previously untreated CLL cases, a multivariate analysis indicated that aberrations (N=44; mixed pathogenic germline and somatic) in exons 2-63 of ATM were significantly associated wi… (full text at CIViC) PMID 26837699 · Nadeu et al., 2016 · Open in CIViC	civic
ATM Mutation	(prognostic)	Prognostic	B	Supports Poor Outcome	3	accepted	EID2927 ATM point mutations were found in 8/57 patients with CLL and were associated with a shorter treatment-free interval, suggesting a more aggressive course. PMID 21993670 · Guarini et al., 2012 · Open in CIViC	civic
ATM Mutation	Doxorubicin	Predictive	D	Supports Resistance	4	accepted	EID2222 Primary cells from chronic lymphocytic leukemia patients were treated with doxorubicin to induce double-strand (DSB). In this setting, cells harboring rare ATM variants (n=8) had significantly higher … (full text at CIViC) PMID 23585524 · Navrkalova et al., 2013 · Open in CIViC	civic

Chronic Lymphocytic Leukemia3

ATM Mutation

(prognostic)

Prognostic

Supports Poor Outcome

accepted

EID1539

In a study of 406 previously untreated CLL cases, a multivariate analysis indicated that aberrations (N=44; mixed pathogenic germline and somatic) in exons 2-63 of ATM were significantly associated wi… (full text at CIViC)

PMID 26837699 · Nadeu et al., 2016 · Open in CIViC

civic

ATM Mutation

(prognostic)

Prognostic

Supports Poor Outcome

accepted

EID2927

ATM point mutations were found in 8/57 patients with CLL and were associated with a shorter treatment-free interval, suggesting a more aggressive course.

PMID 21993670 · Guarini et al., 2012 · Open in CIViC

civic

ATM Mutation

Doxorubicin

Predictive

Supports Resistance

accepted

EID2222

Primary cells from chronic lymphocytic leukemia patients were treated with doxorubicin to induce double-strand (DSB). In this setting, cells harboring rare ATM variants (n=8) had significantly higher … (full text at CIViC)

PMID 23585524 · Navrkalova et al., 2013 · Open in CIViC

civic

Diffuse Large B-Cell Lymphoma1
ATM Mutation	(oncogenic)	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11908 This study reportedly sequenced 1001 DLBCL tumors using whole exome sequencing. They reported 150 recurrently mutated genes. Only genes that have been confirmed by other similar studies were added to … (full text at CIViC) PMID 28985567 · Reddy et al., 2017 · Open in CIViC	civic

Diffuse Large B-Cell Lymphoma1

ATM Mutation

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID11908

This study reportedly sequenced 1001 DLBCL tumors using whole exome sequencing. They reported 150 recurrently mutated genes. Only genes that have been confirmed by other similar studies were added to … (full text at CIViC)

PMID 28985567 · Reddy et al., 2017 · Open in CIViC

civic

Glioblastoma1
ATM Mutation	Temozolomide	Predictive	D	Supports Sensitivity Response	3	accepted	EID452 Glioblastoma cell lines were shown to have increased sensitivity to Temozolomide when siRNA-induced ATM knockdown was applied. PMID 23960094 · Eich et al., 2013 · Open in CIViC	civic

Glioblastoma1

ATM Mutation

Temozolomide

Predictive

Supports Sensitivity Response

accepted

EID452

Glioblastoma cell lines were shown to have increased sensitivity to Temozolomide when siRNA-induced ATM knockdown was applied.

PMID 23960094 · Eich et al., 2013 · Open in CIViC

civic

Hematopoietic and Lymphoid Cell Neoplasm1
ATM Mutation	Olaparib	Predictive	D	Supports Sensitivity Response	5	accepted	EID455 Olaparib was found to inhibit cancer cell growth in ATM mutant cell lines of several blood cancers including Lymphoblastoid Leukemia, Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia, and in a murin… (full text at CIViC) PMID 20739657 · Weston et al., 2010 · Open in CIViC	civic

Hematopoietic and Lymphoid Cell Neoplasm1

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

accepted

EID455

Olaparib was found to inhibit cancer cell growth in ATM mutant cell lines of several blood cancers including Lymphoblastoid Leukemia, Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia, and in a murin… (full text at CIViC)

PMID 20739657 · Weston et al., 2010 · Open in CIViC

civic

Lymphoma1
ATM Mutation	Camptothecin	Predictive	D	Supports Sensitivity Response	3	submitted	EID12758 In murine embryonic fibroblasts (MEFs), the authors expressed two ATM missense variants (D2880A and N2885K) and a hematopoietic stem cell specific Cre recombinase that inactivates the conditional ATM … (full text at CIViC) PMID 27304073 · Yamamoto et al., 2016 · Open in CIViC	civic

Lymphoma1

ATM Mutation

Camptothecin

Predictive

Supports Sensitivity Response

submitted

EID12758

In murine embryonic fibroblasts (MEFs), the authors expressed two ATM missense variants (D2880A and N2885K) and a hematopoietic stem cell specific Cre recombinase that inactivates the conditional ATM … (full text at CIViC)

PMID 27304073 · Yamamoto et al., 2016 · Open in CIViC

civic

Malignant Colorectal Neoplasm1
ATM Mutation	Olaparib	Predictive	B	Does Not Support Sensitivity Response	2	submitted	EID13082 In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the colorectal cancer cohort (27 evaluable patients) there was one PR and thre… (full text at CIViC) PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC	civic

Malignant Colorectal Neoplasm1

ATM Mutation

Olaparib

Predictive

Does Not Support Sensitivity Response

submitted

EID13082

In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the colorectal cancer cohort (27 evaluable patients) there was one PR and thre… (full text at CIViC)

PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC

civic

Malignant Lung Neoplasm1
ATM Mutation	Olaparib	Predictive	B	Supports Sensitivity Response	3	submitted	EID13084 In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the lung cancer cohort (20 evaluable patients) there were four PRs and five pa… (full text at CIViC) PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC	civic

Malignant Lung Neoplasm1

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

submitted

EID13084

In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the lung cancer cohort (20 evaluable patients) there were four PRs and five pa… (full text at CIViC)

PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC

civic

Malignant Pancreatic Neoplasm1
ATM Mutation	Olaparib	Predictive	B	Does Not Support Sensitivity Response	2	submitted	EID13083 In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the pancreatic cancer cohort (25 evaluable patients) there was one PR and five… (full text at CIViC) PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC	civic

Malignant Pancreatic Neoplasm1

ATM Mutation

Olaparib

Predictive

Does Not Support Sensitivity Response

submitted

EID13083

In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the pancreatic cancer cohort (25 evaluable patients) there was one PR and five… (full text at CIViC)

PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC

civic

Malignant Prostate Neoplasm3
ATM Mutation	Olaparib	Predictive	B	Does Not Support Sensitivity Response	3	submitted	EID7458 In a retrospective study, 23 consecutive patients with prostate cancer harboring germline BRCA1/2 or ATM mutations were treated with olaparib were reviewed. This study included 2 patients with BRCA1 m… (full text at CIViC) PMID 30797618 · Marshall et al., 2019 · Open in CIViC	civic
ATM Mutation	Olaparib	Predictive	B	Supports Sensitivity Response	3	submitted	EID7472 In a phase 2 trial, patients with metastatic castration-resistant prostate cancer harboring DNA damage repair (DDR) gene aberrations were treated with olaparib. In gene testing, samples from tumor tis… (full text at CIViC) Open in CIViC	civic
ATM Mutation	Olaparib	Predictive	C	Supports Sensitivity Response	3	accepted	EID1960 Response to olaparib was observed in 4 of 5 with prostate cancer patients with ATM aberrations (2 germline). PMID 26510020 · Mateo et al., 2015 · Open in CIViC	civic

Malignant Prostate Neoplasm3

ATM Mutation

Olaparib

Predictive

Does Not Support Sensitivity Response

submitted

EID7458

In a retrospective study, 23 consecutive patients with prostate cancer harboring germline BRCA1/2 or ATM mutations were treated with olaparib were reviewed. This study included 2 patients with BRCA1 m… (full text at CIViC)

PMID 30797618 · Marshall et al., 2019 · Open in CIViC

civic

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

submitted

EID7472

In a phase 2 trial, patients with metastatic castration-resistant prostate cancer harboring DNA damage repair (DDR) gene aberrations were treated with olaparib. In gene testing, samples from tumor tis… (full text at CIViC)

Open in CIViC

civic

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

accepted

EID1960

Response to olaparib was observed in 4 of 5 with prostate cancer patients with ATM aberrations (2 germline).

PMID 26510020 · Mateo et al., 2015 · Open in CIViC

civic

Mantle Cell Lymphoma1
ATM Mutation	Olaparib	Predictive	D	Supports Sensitivity Response	3	accepted	EID1907 Two ATM deficient mantle cell lymphoma (MCL) cell lines were more sensitive to PARP-1 inhibition with olaparib or PJ-34 than 4 other MCL cell lines. shRNA mediated ATM knockdown in a cell line increas… (full text at CIViC) PMID 20124459 · Williamson et al., 2010 · Open in CIViC	civic

Mantle Cell Lymphoma1

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

accepted

EID1907

Two ATM deficient mantle cell lymphoma (MCL) cell lines were more sensitive to PARP-1 inhibition with olaparib or PJ-34 than 4 other MCL cell lines. shRNA mediated ATM knockdown in a cell line increas… (full text at CIViC)

PMID 20124459 · Williamson et al., 2010 · Open in CIViC

civic

Melanoma1
ATM Mutation	Temozolomide	Predictive	D	Supports Sensitivity Response	3	accepted	EID453 Melanoma cell lines were shown to have increased sensitivity to Temozolomide when siRNA-induced ATM knockdown was applied. PMID 23960094 · Eich et al., 2013 · Open in CIViC	civic

Melanoma1

ATM Mutation

Temozolomide

Predictive

Supports Sensitivity Response

accepted

EID453

Melanoma cell lines were shown to have increased sensitivity to Temozolomide when siRNA-induced ATM knockdown was applied.

PMID 23960094 · Eich et al., 2013 · Open in CIViC

civic

Sarcoma1
ATM Mutation OR TP53 Mutation OR PIK3R1 Mutation OR PIK3CB Mutation OR NTRK1 Mutation OR CSF2RB Mutation	Doxorubicin	Predictive	D	Supports Sensitivity Response	3	submitted	EID12721 In primary soft tissue sarcoma cultures (UPS n = 25, SS n = 12), tumors with at least one mutation in apoptosis pathway genes (TP53, ATM, PIK3CB, PIK3R1, NTRK1 or CSF2RB; Mut+ n = 10, Mut− n = 27) wer… (full text at CIViC) PMID 35406568 · Kirilin et al., 2022 · Open in CIViC	civic

Sarcoma1

ATM Mutation OR TP53 Mutation OR PIK3R1 Mutation OR PIK3CB Mutation OR NTRK1 Mutation OR CSF2RB Mutation

Doxorubicin

Predictive

Supports Sensitivity Response

submitted

EID12721

In primary soft tissue sarcoma cultures (UPS n = 25, SS n = 12), tumors with at least one mutation in apoptosis pathway genes (TP53, ATM, PIK3CB, PIK3R1, NTRK1 or CSF2RB; Mut+ n = 10, Mut− n = 27) wer… (full text at CIViC)

PMID 35406568 · Kirilin et al., 2022 · Open in CIViC

civic

Solid Neoplasm1
ATM Mutation	Olaparib	Predictive	B	Supports Sensitivity Response	2	submitted	EID13081 In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the histology pooled cohort (36 evaluable patients) comprised of 19 different … (full text at CIViC) PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC	civic

Solid Neoplasm1

ATM Mutation

Olaparib

Predictive

Supports Sensitivity Response

submitted

EID13081

In this phase II basket trial (TAPUR), response to olaparib treatment was examined in four cohorts with ATM mutations. In the histology pooled cohort (36 evaluable patients) comprised of 19 different … (full text at CIViC)

PMID 41538762 · Carrizosa et al., 2026 · Open in CIViC

civic

Evidence by cancer (20 items)

Clinical significance (0)