DNMT1 — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DNMT1 EXPRESSION2
Cisplatin	Gastric Adenocarcinoma	Predictive	B	Supports Resistance	3	accepted	EID946 High DNMT1 expression was found in 105/127 (83%) or patients (by qPCR assay). Low DNMT1 expression was associated with improved histopathological and clinical response and OS in patients with gastric … (full text at CIViC) PMID 21458988 · Mutze et al., 2011 · Open in CIViC	civic
Decitabine	Malignant Ovarian Neoplasm	Predictive	D	Supports Sensitivity Response	3	accepted	EID819 DNMT1 expression (mRNA expression from an independent study) correlated with sensitivity to decitabine (ρ, −0.443, Pearson regression analysis) in this preclinical study of 45 solid tumor cell lines. … (full text at CIViC) PMID 25968887 · Stewart et al., 2015 · Open in CIViC

Cohorts

Alteration frequency by cohort (113)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved113 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Cancer-IDH Driver Mutant Cohort (MSK, 2024) prad_idhmut_msk_2025	Prostate Adenocarcinoma	Ssm	2	99	2%

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
· Eur J Cancer · 2011 · PMID 21458988 · validated civic_curation pubmed
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
· Cancer Res · 2015 · PMID 25968887 · validated civic_curation pubmed