DNMT1 NM_001130823.3(DNMT1):c.891+8C>T

CI-VAR-00031631Explore in graph →NM_001130823.3:c.891+8C>TClinVar 193835 rs117294281

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
193835	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Hereditary sensory neuropathy-deafness-dementia syndrome; DNMT1-related disorder; Sarcoma; Ovarian serous cystadenocarcinoma; Thymoma; Acute myeloid leukemia; Clear cell carcinoma of kidney; Malignant tumor of esophagus; Cervical cancer	germline	13	Jun 01, 2026	clinvar