Publication
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Ovarian Neoplasmcivic_curation1.00
- drugDecitabinecivic_curation1.00
- geneDNMT1civic_curation1.00
- geneKRAScivic_curation1.00
- variantDNMT1 EXPRESSIONcivic_curation1.00
- variantKRAS Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25968887
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DNMT1 EXPRESSION1 | ||||||||
| Decitabine | Malignant Ovarian Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID819DNMT1 expression (mRNA expression from an independent study) correlated with sensitivity to decitabine (ρ, −0.443, Pearson regression analysis) in this preclinical study of 45 solid tumor cell lines. … (full text at CIViC) PMID 25968887 · Stewart et al., 2015 · Open in CIViC | civic |
| KRAS Mutation1 | ||||||||
| Decitabine | Malignant Ovarian Neoplasm | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID820KRAS mutation or amplification predicted sensitivity to decitabine in ovarian cancer cell lines. The authors profiled the response of 45 ovarian, melanoma, and breast cancer cell lines over 9 days of … (full text at CIViC) PMID 25968887 · Stewart et al., 2015 · Open in CIViC | civic |