DNMT1 EXPRESSION

CI-VAR-00000904Explore in graph →CIViC 335

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastric Adenocarcinoma1
DNMT1 EXPRESSION	Cisplatin	Predictive	B	Supports Resistance	3	accepted	EID946 High DNMT1 expression was found in 105/127 (83%) or patients (by qPCR assay). Low DNMT1 expression was associated with improved histopathological and clinical response and OS in patients with gastric … (full text at CIViC) PMID 21458988 · Mutze et al., 2011 · Open in CIViC	civic
Malignant Ovarian Neoplasm1
DNMT1 EXPRESSION	Decitabine	Predictive	D	Supports Sensitivity Response	3	accepted	EID819 DNMT1 expression (mRNA expression from an independent study) correlated with sensitivity to decitabine (ρ, −0.443, Pearson regression analysis) in this preclinical study of 45 solid tumor cell lines. … (full text at CIViC) PMID 25968887 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.