DNMT1 NM_001130823.3(DNMT1):c.410C>G (p.Thr137Arg)

CI-VAR-00161862Explore in graph →p.Thr137ArgNM_001130823.3:c.410C>GClinVar 949009 rs377146699

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
949009	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Hereditary sensory neuropathy-deafness-dementia syndrome; Inborn genetic diseases; Hepatocellular carcinoma; Melanoma	germline	4	Apr 01, 2026	clinvar