Gene

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Explore in graph →CI-GENE-00000153HGNC:76 ENSG00000097007 NCBI 25 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (617)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 551–600 of 617 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ABL1 Fusion2
(oncogenic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Oncogenic	C	Supports Oncogenicity	2	submitted	EID13001

Cohorts

Alteration frequency by cohort (122)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved122 cohort rows (showing 22, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Cancer (MSK, Nat Genet 2025) breast_msk_2025	Invasive Breast Carcinoma	Ssm	31

Literature

Linked publications (65)

25 per page, newest first.

pubmedPublishedShowing 1–25 of 65 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Novel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.
· Oncogene · 2002 · PMID 12476305 · validated civic_curation pubmed
BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review.
· Leuk Res · 2010 · PMID 20537386 · validated civic_curation pubmed
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
· N Engl J Med · 2014 · PMID 25207766 · validated civic_curation pubmed
Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia.
· Oncotarget · 2017 · PMID 27894077 · validated civic_curation pubmed

ABL1 Fusion5
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	B	Supports Positive	4	accepted	EID9073 This study determined the incidence, clinical characteristics and associated genetic abnormalities in hematologic malignancies with the ETV6-ABL1 fusion. The total of 44 new and previously published E… (full text at CIViC) PMID 27229714 · Zaliova et al., 2016 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	2	submitted	EID11614 B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 of 2 patients (ages 5 and 82 ye… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
Dasatinib	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Predictive	C	Supports Sensitivity Response	2	accepted	EID6969 An adult patient (82 yo) who presented with B-ALL (initial WBC of 183,000) with ETV6-ABL1 fusion was treated with dasatinib as a single agent after his chemotherapy had to be stopped due to toxicity. … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
Imatinib	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Predictive	C	Supports Sensitivity Response	3	accepted	EID9171 A 4-year-old female presented with relapsed B-cell precursor ALL and no MLL or BCR-ABL1 rearrangement per cytogenetic studies. During multiple periods of short remission and relapse she was treated wi… (full text at CIViC) PMID 30028819 · Mankuzhy et al., 2019 · Open in CIViC	civic
Dasatinib + Imatinib + NilotinibSubstitutes	Myeloid Neoplasm	Predictive	B	Supports Sensitivity Response	2	submitted	EID11326 In this study, 18 patients with PCM1-JAK2 (n = 8), BCR-JAK2 (n = 1), and ETV6-ABL1 (n = 9) fusion genes were enrolled. RT-PCR was performed for confirmation of PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion… (full text at CIViC) PMID 32279331 · Schwaab et al., 2020 · Open in CIViC	civic

ABL1 Fusion5

(diagnostic)

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Diagnostic

Supports Positive

accepted

EID9073

This study determined the incidence, clinical characteristics and associated genetic abnormalities in hematologic malignancies with the ETV6-ABL1 fusion. The total of 44 new and previously published E… (full text at CIViC)

PMID 27229714 · Zaliova et al., 2016 · Open in CIViC

ABL1 Fusion6
(diagnostic)	Acute Lymphoblastic Leukemia	Diagnostic	B	Supports Positive	3	rejected	EID9155 FOXP1-ABL1 fusion was identified in Ph-like ALL PMID 31935290 · Harvey et al., 2020 · Open in CIViC	civic
(oncogenic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Oncogenic	C	Supports Oncogenicity	2	accepted	EID7253 In a 16-year old Caucasian female with B-lymphoblastic leukemia (B-ALL), the t(3;9)(p12;q34) was identified by cytogenetic studies. 5'RACE PCR detected the in-frame FOXP1::ABL1 (exon 19::exon 4) fusio… (full text at CIViC) PMID 21391972 · Ernst et al., 2011 · Open in CIViC	civic
(prognostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Prognostic	C	Supports Poor Outcome	1	accepted	EID7651 The FOXP1::ABL1 fusion was identified in a male patient in a Dutch/German cohort of 77 BCR::ABL1-like cases. The FOXP1::ABL1 fusion was confirmed by PCR and targeted ligation amplification, and was fo… (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC	civic
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	1	accepted	EID11615 B-lymphoblastic leukemia/lymphoma (B-ALL) cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine BCR::ABL1-like… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
(prognostic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Prognostic	D	Supports Poor Outcome	4	rejected	EID9154 This study comprised 127 consecutive patients (age ≥16 years) with newly diagnosed BCP-ALL with available molecular data.The non-response rate, defined as the proportion of patients who had not achiev… (full text at CIViC) PMID 25769542 · Boer et al., 2015 · Open in CIViC	civic
Dasatinib	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Predictive	C	Supports Sensitivity Response	1	accepted	EID7292 A 16-year-old Caucasian boy was diagnosed with B-lymphoblastic leukemia (B-ALL). Karyotype showed an abnormal clone characterized by the t(3;9)(p13;q34.1). This translocation has been shown previously… (full text at CIViC) PMID 30938769 · Yenamandra et al., 2019 · Open in CIViC	civic