ABL1 BCR::ABL E255V

CI-VAR-00005084Explore in graph →CIViC 1173

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive2
ABL1 BCR::ABL E255V	Imatinib	Predictive	C	Supports Resistance	3	rejected	EID7821 One chronic myeloid leukemia patient in chronic phase had a minimal best cytogenetic response to imatinib but became resistant. Bacterial clones generated using peripheral blood RNA later showed the B… (full text at CIViC) PMID 16775234 · Talpaz et al., 2006 · Open in CIViC	civic
ABL1 BCR::ABL E255V	Imatinib Mesylate	Predictive	D	Supports Resistance	2	rejected	EID6277 In an in vitro study, a Ba/F3-p210BCR-ABL1 cell line was ENU-mutated and exposed to graded concentrations of imatinib, nilotinib or dasatinib to identify resistance mutations. The E255V mutation in th… (full text at CIViC) PMID 16772610 · Bradeen et al., 2006 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.