Cancer Family
Neoplasm
CI-CAN-00000001Explore in graph →
Non-malignant22,950 active trials259 approved drugs4,031 evidence items
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Cancer Family
CI-CAN-00000001Explore in graph →
Genomics
495 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
622 cases with simple somatic mutation data · 672 cases total · 2026-01-05 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | FLT3 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 179 |
| 622 |
| 28.8% |
| cbioportal |
| 2 | DNMT3A | Ssm | 139 | 622 | 22.3% | cbioportal |
| 3 | NPM1 | Ssm | 135 | 622 | 21.7% | cbioportal |
| 4 | NRAS | Ssm | 77 | 622 | 12.4% | cbioportal |
| 5 | TET2 | Ssm | 76 | 622 | 12.2% | cbioportal |
| 6 | IDH2 | Ssm | 74 | 622 | 11.9% | cbioportal |
| 7 | RUNX1 | Ssm | 74 | 622 | 11.9% | cbioportal |
| 8 | SRSF2 | Ssm | 71 | 622 | 11.4% | cbioportal |
| 9 | WT1 | Ssm | 56 | 622 | 9% | cbioportal |
| 11 | TP53 | Ssm | 54 | 622 | 8.7% | cbioportal |
| 10 | IDH1 | Ssm | 54 | 622 | 8.7% | cbioportal |
| 12 | ASXL1 | Ssm | 49 | 622 | 7.9% | cbioportal |
| 13 | BCOR | Ssm | 34 | 622 | 5.5% | cbioportal |
| 14 | CEBPA | Ssm | 33 | 622 | 5.3% | cbioportal |
| 15 | STAG2 | Ssm | 33 | 622 | 5.3% | cbioportal |
| 16 | SF3B1 | Ssm | 32 | 622 | 5.1% | cbioportal |
| 18 | U2AF1 | Ssm | 29 | 622 | 4.7% | cbioportal |
| 17 | PTPN11 | Ssm | 29 | 622 | 4.7% | cbioportal |
| 19 | JAK2 | Ssm | 28 | 622 | 4.5% | cbioportal |
| 20 | KRAS | Ssm | 25 | 622 | 4% | cbioportal |
| 22 | GATA2 | Ssm | 22 | 622 | 3.5% | cbioportal |
| 21 | EZH2 | Ssm | 22 | 622 | 3.5% | cbioportal |
| 23 | PHF6 | Ssm | 18 | 622 | 2.9% | cbioportal |
| 24 | RAD21 | Ssm | 16 | 622 | 2.6% | cbioportal |
| 25 | PDS5B | Ssm | 14 | 622 | 2.3% | cbioportal |
| 26 | BCORL1 | Ssm | 12 | 622 | 1.9% | cbioportal |
| 27 | CBL | Ssm | 12 | 622 | 1.9% | cbioportal |
| 28 | ZRSR2 | Ssm | 12 | 622 | 1.9% | cbioportal |
| 30 | KIT | Ssm | 11 | 622 | 1.8% | cbioportal |
| 29 | CSF3R | Ssm | 11 | 622 | 1.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-05