Cancer Family
Neoplasm
CI-CAN-00000001Explore in graph →
Non-malignant22,950 active trials259 approved drugs4,031 evidence items
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Cancer Family
CI-CAN-00000001Explore in graph →
Genomics
495 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
619 cases with simple somatic mutation data · 619 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 361 |
| 619 |
| 58.3% |
| cbioportal |
| 2 | TP53 | Ssm | 320 | 619 | 51.7% | cbioportal |
| 3 | TTN | Ssm | 295 | 619 | 47.7% | cbioportal |
| 4 | KRAS | Ssm | 173 | 619 | 27.9% | cbioportal |
| 5 | SYNE1 | Ssm | 167 | 619 | 27% | cbioportal |
| 6 | FLG | Ssm | 154 | 619 | 24.9% | cbioportal |
| 7 | MUC16 | Ssm | 150 | 619 | 24.2% | cbioportal |
| 8 | PIK3CA | Ssm | 132 | 619 | 21.3% | cbioportal |
| 9 | MUC17 | Ssm | 129 | 619 | 20.8% | cbioportal |
| 10 | BRAF | Ssm | 127 | 619 | 20.5% | cbioportal |
| 11 | OBSCN | Ssm | 116 | 619 | 18.7% | cbioportal |
| 12 | RYR1 | Ssm | 111 | 619 | 17.9% | cbioportal |
| 13 | FAT4 | Ssm | 109 | 619 | 17.6% | cbioportal |
| 15 | NEB | Ssm | 106 | 619 | 17.1% | cbioportal |
| 14 | AHNAK2 | Ssm | 106 | 619 | 17.1% | cbioportal |
| 16 | CSMD3 | Ssm | 104 | 619 | 16.8% | cbioportal |
| 17 | LRP1B | Ssm | 100 | 619 | 16.2% | cbioportal |
| 18 | PLEC | Ssm | 99 | 619 | 16% | cbioportal |
| 19 | DNAH5 | Ssm | 98 | 619 | 15.8% | cbioportal |
| 20 | SDK1 | Ssm | 93 | 619 | 15% | cbioportal |
| 21 | KMT2C | Ssm | 92 | 619 | 14.9% | cbioportal |
| 22 | UBR4 | Ssm | 91 | 619 | 14.7% | cbioportal |
| 24 | HRNR | Ssm | 90 | 619 | 14.5% | cbioportal |
| 23 | FAT3 | Ssm | 90 | 619 | 14.5% | cbioportal |
| 25 | DIDO1 | Ssm | 89 | 619 | 14.4% | cbioportal |
| 26 | AHNAK | Ssm | 87 | 619 | 14.1% | cbioportal |
| 27 | FBXW7 | Ssm | 86 | 619 | 13.9% | cbioportal |
| 28 | USH2A | Ssm | 84 | 619 | 13.6% | cbioportal |
| 29 | HMCN1 | Ssm | 81 | 619 | 13.1% | cbioportal |
| 30 | RNF213 | Ssm | 80 | 619 | 12.9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-06