Malignant Digestive System Neoplasm

MLH1 Q149* (c.445C > T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 65 year old female patient with suspected Lynch Syndrome (LS). The patient … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 Q426fs (c.1276del), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be a somatic mutation in a 46 year old male patient (patient id: sLS-5) with suspected Lync… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

R100* (c.298C > T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 46 year old female patient with suspected Lynch Syndrome (LS). The patient was t… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 R226* (c.676C > T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 65 year old female patient (sLS-14) with suspected Lynch Syndrome (LS). The… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 R265G (c.793C > G), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 65 year old female patient (id: sLS-10) with suspected Lynch Syndrome (LS).… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 R687fs (c.2059del), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 33 year old male patient (patient id: sLS-3) with suspected Lynch Syndrome … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 T117M (c.350C > T), identified in three cases of microsatellite-unstable colorectal cancer, was confirmed to be somatic in patients with suspected Lynch Syndrome (LS). The patients were therefore… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (V213fs), identified in two cases of microsatellite-unstable colorectal cancer, was confirmed to be somatic in both patients (40 year-old female & 70 year-old male) with suspected Lynch S… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 V49A (c.146 T > C), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 68 year old female patient (id: sLS-7) with suspected Lynch Syndrome (LS). … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 V534R (c.1600_1601delinsAG), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be a somatic variant in a 27 year old male patient (id: sLS-24) with suspected Lyn… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (E28fs), identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 66 year-old male patient with suspected Lynch Syndrome (LS). The patient was th… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MSH2 K172*, identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 66 year old male patient (id: sLS-32) with suspected Lynch Syndrome (LS). The patient wa… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (V273fs), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be a somatic mutation in a 61 year-old male patient (sLS-27) with suspected Lynch Syndrome (L… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

To assess the effects of MSH3 status on chemosensitivity, MSH3-deficient and MSH3-proficient HCT116 cells were treated with oxaliplatin, SN-38 (irinotecan metabolite), and 5-FU. Parental MSH3-deficien… (full text at CIViC)

PMID 23724141 · Park et al., 2013 · Open in CIViC

This variant (I891fs), identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 79 year-old male patient with suspected Lynch Syndrome (LS). The patient was t… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant, identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a patient with suspected Lynch Syndrome (LS). The patient was therefore negative for LS. … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant, identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a patient with suspected Lynch Syndrome (LS). The patient was therefore negative for LS.

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MSH6 R1242C (c.3724C > T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 53 year old male patient with suspected Lynch Syndrome (LS). The patient … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (R1242H), identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 79 year-old male patient (sLS-37) with suspected Lynch Syndrome (LS). The pati… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This study looked specifically at the prognostic significance of Microsatellite Instability High (MSI-H) in sporadic Australian Clinico Pathological Stage C colorectal cancer in patients from a single… (full text at CIViC)

PMID 10971428 · Wright et al., 2000 · Open in CIViC

47 patients with locally advanced rectal cancer were treated with dostarlimab. 41 completed treatment and achieved a clinical complete response. No patients experienced local or distant disease recurr… (full text at CIViC)

Open in CIViC

Thirty-five MSI-H/dMMR patients were treated with anti-PD-1 therapy. Of the 35 patients, 10 patients harboured B2M mutations, and 8 patients harboured JAK mutations. A low TMB score was noted in patie… (full text at CIViC)

PMID 35343934 · Zhang et al., 2022 · Open in CIViC

Patients with the wild type (C/C) MTHFR gene are 2.91 times (95% CI: [1.23, 6.89]) more likely to have a positive response to neoadjuvant CRT and 3.25 times more likely not to experience relapse (95%… (full text at CIViC)

PMID 26693073 · Nikas et al., 2015 · Open in CIViC

The MTHFR C667T variant was associated with significantly lower relapse-free survival and overall survival in stomach cancer patients treated with 5-Fluorouracil-based therapies. 116 Chinese patients … (full text at CIViC)

PMID 18704422 · Huang et al., 2009 · Open in CIViC

This study found the clinical BTK/ERBB2 kinase inhibitor, ibrutinib, downregulated ERK-mediated signal transduction, cMYC Ser-62 phosphorylation and levels of MYC protein, and elicited G1 cell cycle a… (full text at CIViC)

PMID 28830912 · Chong et al., 2018 · Open in CIViC

Collectively data from expression analysis of 102 esophageal squamous cell carcinoma (ESCC) sample tissues established MYC and HSP90 as potential targets with overexpression of MYC observed in over ha… (full text at CIViC)

PMID 32308431 · Guan et al., 2020 · Open in CIViC

In a retrospective cohort analysis of colon adenocarcinoma treated with PD-1/PD-L1 immune checkpoint inhibitors from the MSKCC ICIs-treated COAD dataset (n = 76; NCOA3-mutant n = 7, NCOA3-wild-type n … (full text at CIViC)

PMID 40215778 · Liu et al., 2025 · Open in CIViC

IHC was performed in 123 hepatocellular carcinoma tissues and their adjacent normal liver tissues for protein expression of HEF1 (NEDD9). Overexpression of HEF1 protein was observed in HCC tissue when… (full text at CIViC)

PMID 26893853 · Li et al., 2016 · Open in CIViC

shRNA-mediated NME1 knockdown significantly increased fluorouracil sensitivity in HCT-116, HT-29, and SW620 colorectal cancer cells. The study reports 4- to 13-fold decreases in IC50 across the NME1, … (full text at CIViC)

PMID 21449674 · Muhale et al., 2011 · Open in CIViC

NOTCH1 amplifications (as determined by FISH) were significantly (log-rank p = 0.025) associated with worse survival in a cohort of 116 patients with colorectal cancer.

PMID 26152787 · Arcaroli et al., 2016 · Open in CIViC

NOTCH1 copy-number gain in a patient-derived tumor xenograft model of colorectal cancer, was associated with increased NOTCH1 and JAG1 activity and response to a NOTCH1-targeting antibody (PF-06293622… (full text at CIViC)

PMID 26152787 · Arcaroli et al., 2016 · Open in CIViC

Notably, the antitumor efficacy of OMP-59R5 in combination with gemcitabine was significantly associated with expression of human Notch3 gene in pancreatic cancer. Tumors that were more sensitive to t… (full text at CIViC)

PMID 25934888 · Yen et al., 2015 · Open in CIViC

Finally, treatment of CRC cells with anti-Notch2/3 antibody increased Numb protein while significantly reducing formation of spheroids in both MICOL-14tum cells and primary tumor cultures. This novel … (full text at CIViC)

PMID 24525742 · Pastò et al., 2014 · Open in CIViC

The Medical Research Council (MRC) COIN trial consisted of patients with histologically confirmed adenocarcinoma of the colon or rectum, inoperable metastatic or locoregional measurable disease, and w… (full text at CIViC)

PMID 21641636 · Maughan et al., 2011 · Open in CIViC

A 27-year old male patient displayed poorly differentiated gastric adenocarcinoma and massive malignant ascites. Shortly after his diagnosis, the patient died. After genomic sequencing, it was shown t… (full text at CIViC)

PMID 26375439 · Lee et al., 2015 · Open in CIViC

In preclinical gastric carcinoma models, NPTXR overexpression conferred sensitivity to NPTXR-targeted therapy. In xenograft mouse models of gastric cancer (MKN1; n = 3–4 mice per group), treatment wi… (full text at CIViC)

PMID 32847597 · Kanda et al., 2020 · Open in CIViC

In preclinical pancreatic ductal adenocarcinoma (PDAC) models with high NQ01 expression, which indicates the NFE2L2 (NRF2) pathway activation, the small molecule NSC84167 (NSLC01, 50 mg/kg) selectivel… (full text at CIViC)

PMID 34247201 · Dai et al., 2021 · Open in CIViC

Statistical analysis showed that the inverse relationship between COUP-TF II and SMAD4 expression was shown in 112 different patients with Colorectal Cancer(CRC)(45 COUP-TF II-positive/SMAD4-negative … (full text at CIViC)

PMID 26261604 · Wang et al., 2015 · Open in CIViC

In pancreatic cancer cell lines MiaPaCa2 and Panc1, gemcitabine 1 μmol/L induced NR4A2/NURR1 expression and triggered cytoprotective autophagy, while both CRISPR-mediated NR4A2 knockout and the NR4A2 … (full text at CIViC)

PMID 35582016 · Zarei et al., 2021 · Open in CIViC

In a retrospective TCGA PDAC (tumors n = 179, normals n = 171), high ATG7 expression was significantly associated with poorer survival on Kaplan–Meier analysis (P = 0.013), and high ATG12 expression s… (full text at CIViC)

PMID 35582016 · Zarei et al., 2021 · Open in CIViC

In an in vitro study, an OXCO-2 cell line expressing NRAS G12C mutation demonstrated acquired resistance after low level cetuximab exposure compared to OXCO-2 parental cells expressing NRAS wild-type.… (full text at CIViC)

PMID 24553387 · Misale et al., 2014 · Open in CIViC

Two patients participating in a large retrospective trial of cetuximab in metastatic, treatment refractory colorectal cancer had tumors which harbored NRAS G12C and were wild type for KRAS, PIK3CA, an… (full text at CIViC)

PMID 20619739 · De Roock et al., 2010 · Open in CIViC

In a retrospective study of 148 treatment naive metastatic colorectal cancer patients, patients with RAS mutations (n=10), including KRAS A146T, KRAS G13D, NRAS G12D and NRAS Q179*, treated with FOLFO… (full text at CIViC)

PMID 25666295 · Kaczirek et al., 2015 · Open in CIViC

In an in vitro study, an OXCO-2 cell line expressing NRAS G12D mutation demonstrated acquired resistance after low level cetuximab exposure compared to OXCO-2 parental cells expressing NRAS wild-type.… (full text at CIViC)

PMID 24553387 · Misale et al., 2014 · Open in CIViC