MYC Overexpression

CI-VAR-00003172Explore in graph →CIViC 1303

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 4 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Esophageal Squamous Cell Carcinoma1
MYC Overexpression	Ganetespib	Predictive	D	Supports Sensitivity Response	3	submitted	EID10151 Collectively data from expression analysis of 102 esophageal squamous cell carcinoma (ESCC) sample tissues established MYC and HSP90 as potential targets with overexpression of MYC observed in over ha… (full text at CIViC) PMID 32308431 · Guan et al., 2020 · Open in CIViC	civic
Lung Small Cell Carcinoma1
MYC Overexpression	Cisplatin + Olaparib + PrexasertibCombination	Predictive	D	Supports Sensitivity Response	4	accepted	EID3003 A preclinical study to evaluate the efficacy of targeting the overexpressed CHEK1 cell cycle chekpoint kinase, including both miRNA and Prexasertib-induced inhibition. Both in vitro and in vivo, Prexa…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Lung Squamous Cell Carcinoma1
FGFR1 Amplification AND MYC Overexpression	Pazopanib	Predictive	C	Supports Sensitivity Response	2	accepted	EID7811 Patient diagnosed with metastatic squamous cell lung cancer had high-level amplification of FGFR1 and high expression of MYC. Patient was treated with 400 mg pazopanib twice a day. CT taken four and… (full text at CIViC) PMID 24302556 · Malchers et al., 2014 · Open in CIViC	civic

Multiple Myeloma1
MYC Overexpression	JQ-1	Predictive	D	Supports Sensitivity Response	5	accepted	EID5505 BET inhibition by JQ1 downregulates MYC transcription, followed by genome-wide downregulation of Myc-dependent target genes. In experimental models of multiple myeloma, a Myc-dependent hematologic mal… (full text at CIViC) PMID 21889194 · Delmore et al., 2011 · Open in CIViC	civic