NOTCH1 Amplification

CI-VAR-00000210Explore in graph →CIViC 330

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm2
NOTCH1 Amplification	(prognostic)	Prognostic	B	Supports Poor Outcome	2	accepted	EID812 NOTCH1 amplifications (as determined by FISH) were significantly (log-rank p = 0.025) associated with worse survival in a cohort of 116 patients with colorectal cancer. PMID 26152787 · Arcaroli et al., 2016 · Open in CIViC	civic
NOTCH1 Amplification	NOTCH1 Antibody (PF-06293622)	Predictive	D	Supports Sensitivity Response	2	accepted	EID811 NOTCH1 copy-number gain in a patient-derived tumor xenograft model of colorectal cancer, was associated with increased NOTCH1 and JAG1 activity and response to a NOTCH1-targeting antibody (PF-06293622… (full text at CIViC) PMID 26152787 · Arcaroli et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.