Gene

NR4A2

nuclear receptor subfamily 4 group A member 2

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NR4A2 Overexpression2
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID12648 NR4A2 was highly expressed in glioblastoma cell lines 15037, 14015s, and U87-MG, and NR4A2 antagonists DIM-C-pPhCl, 3-CF3-4-Cl, and 2-OH-4-Br decreased proliferation, migration, and invasion in all th… (full text at CIViC) PMID 31754919 · Karki et al., 2020 · Open in CIViC	civic
C-DIM 12 + GemcitabineCombination	Pancreatic Ductal Adenocarcinoma	Predictive	D	Supports Resistance	3	submitted	EID12649 In pancreatic cancer cell lines MiaPaCa2 and Panc1, gemcitabine 1 μmol/L induced NR4A2/NURR1 expression and triggered cytoprotective autophagy, while both CRISPR-mediated NR4A2 knockout and the NR4A2 … (full text at CIViC)

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

Data not yet available

No publication linked to this gene yet.