ATG12

autophagy related 12

Explore in graph →CI-GENE-00021230HGNC:588 ENSG00000145782 NCBI 9140 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ATG12 Overexpression + ATG7 Overexpression + NR4A2 OverexpressionNR4A2 ATG7 ATG121
(prognostic)	Pancreatic Ductal Adenocarcinoma	Prognostic	B	Supports Poor Outcome	3	submitted	EID12650 In a retrospective TCGA PDAC (tumors n = 179, normals n = 171), high ATG7 expression was significantly associated with poorer survival on Kaplan–Meier analysis (P = 0.013), and high ATG12 expression s… (full text at CIViC) PMID 35582016 · Zarei et al., 2021 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Neuroblastoma (Broad, Nature 2015) nbl_ucologne_2015	Neuroblastoma	Ssm	1	56	1.8%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.