NPTXR Overexpression

CI-VAR-00003255Explore in graph →CIViC 5396

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastric Carcinoma1
NPTXR Overexpression	Cisplatin + FluorouracilCombination	Predictive	D	Supports Sensitivity Response	3	submitted	EID12774 In preclinical gastric carcinoma models, NPTXR overexpression conferred sensitivity to NPTXR-targeted therapy. In xenograft mouse models of gastric cancer (MKN1; n = 3–4 mice per group), treatment wi… (full text at CIViC) PMID 32847597 · Kanda et al., 2020 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.