Variant · Snv

NRAS G12D

CI-VAR-00001607Explore in graph →NP_002515.1:p.Gly12AspNM_002524.4:c.35G>AClinVar 39648 CIViC 878 rs121913237

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm7
NRAS G12D	Cetuximab	Predictive	B	Supports Resistance	—	accepted	EID3693 In a retrospective study of 148 treatment naive metastatic colorectal cancer patients, patients with RAS mutations (n=10), including KRAS A146T, KRAS G13D, NRAS G12D and NRAS Q179*, treated with FOLFO… (full text at CIViC) PMID 25666295 · Kaczirek et al., 2015 · Open in CIViC	civic
NRAS G12D	Cetuximab	Predictive	D	Supports Resistance	—	submitted	EID3691 In an in vitro study, an OXCO-2 cell line expressing NRAS G12D mutation demonstrated acquired resistance after low level cetuximab exposure compared to OXCO-2 parental cells expressing NRAS wild-type.… (full text at CIViC) PMID 24553387 · Misale et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
39648	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Epidermal nevus; Juvenile myelomonocytic leukemia; Noonan syndrome 6; Noonan syndrome and Noonan-related syndrome; RASopathy; Autoimmune lymphoproliferative syndrome type 4; NRAS-related disorder; Cardiovascular phenotype; Colorectal cancer; Large congenital melanocytic nevus; Germinoma; Neoplasm	germline/somatic